Monters vs. Aliens is a 2019 American science-fiction action comedy film produced by DreamWorks Pictures. It is a live-action adaptation of DreamWorks Animation's 2019 film of the same name.
Out beyond the far reaches of space, an unknown planet explodes sending a strange meteorite across the galaxy, heading towards Earth. Meanwhile, Susan Murphy of Modesto, California is going to be married to news weatherman Derek Dietl. Just before the ceremony, she is hit by the meteorite and its energy causes her to glow green and grow to an enormous size with her hair turned white. She is tranquilized by the military and awakens in a top secret government facility that houses monsters of which the public are ignorant. She meets General W.R. Monger, the Army officer in charge of the facility, and her fellow monster inmates: Dr. Cockroach PhD, a mad scientist who became half-human, half-cockroach after an experiment; B.O.B. (Benzoate Ostylezene Bicarbonate), a brainless, living mass of blue goo as a result of a food flavoring mutation; Insectosaurus, a massive mutated bug standing 350 feet in height, and the Missing Link, a prehistoric 20,000 year old fish-ape hybrid who was thawed from deep ice by scientists. Susan, herself renamed to Ginormica, is forbidden any contact with her friends and family, leaving her feeling increasingly isolated.
In a mysterious spaceship in deep space, an alien overlord named Gallaxhar is alerted to the presence of quantonium, a powerful energy source on Earth, and he sends a robotic probe to retrieve it. The probe later lands on Earth where the President of the United States attempts to make first contact with it. However, the attempt fails and the probe goes on a destructive rampage, headed straight for San Francisco. Monger convinces the President to grant the monsters their freedom if they can stop the probe. A single person objects to this arrangement and Monger responds by giving him a wedgie. In San Francisco, the robot detects the quantonium radiating through Susan's body and tries to take it from her, putting many lives at risk. At the Golden Gate Bridge, the monsters work together to defeat the probe.
Gallaxhar sets course for Earth to obtain the quantonium in person while the now-free Susan returns home with her new friends and reunites with her family. However, the monsters alienate themselves from the humans due to their inexperience with social situations. Derek breaks off his engagement with Susan, claiming that he cannot marry someone who would overshadow him and his career. Heartbroken, the monsters reunite, but Susan realizes that her life is better as a monster and promises not to sell herself short to anyone again. Suddenly, Susan is pulled into Gallaxhar's spaceship. Insectosaurus tries to save her, but he is shot down by the ship's plasma cannons, seemingly killing him.
On board the ship, Gallaxhar extracts the quantonium from Susan, shrinking her back to her normal size. Gallaxhar then uses the extracted quantonium to create clones of himself in order to launch a full-scale invasion of Earth. Monger manages to get the monsters on board the ship. They rescue Susan and make their way to the main power core where Dr. Cockroach sets the ship to self-destruct to prevent the invasion. All but Susan are trapped as the blast doors close and she personally confronts Gallaxhar on the bridge. With her time running out, she sends the ball of stored quantonium down on herself, restoring her monstrous size and strength. After rescuing her friends, they flee the ship and meet with Monger and Insectosaurus, who has morphed into a butterfly. The ship self-destructs, killing Gallaxhar and his army.
Returning to Modesto, Susan and the monsters receive a hero's welcome. Hoping to take advantage of Susan's fame for his own career, Derek tries to get back together with her, but she rejects him. Monger then arrives to tell the monsters about a new monstrous snail called Escargantua slowly making its way to Paris, and the film ends with the monsters taking off to confront the new menace.