War of Games tells the stories of many characters from famous video games in one shared universe, showing the viewers the possibility of what if some of our beloved heroes and villains from renowned franchises interacted and went on adventures beyond recognition. The series despite being an anthology has a few connecting plot threads.
Season 1 (Ballad of Escapees and Immigrants)
Leo Caruso, after shooting Vincent Moretti dead, moves to Liberty City where he meets the Serbian immigrant Niko Bellic. Both are forced to work together when a ghost from both Leo's past returns to exact his revenge.
Season 2 (The Witcher)
Geralt of Rivia, after defeating the Wild Hunt, is hired by the King of Hyrule to protect his daughter, Zelda, from dangerous threats including the corrupt empress of the Empire of the Isles, Delilah Copperspoon who is receiving help from the mysterious Gerudo, Ganondorf.
Season 3 (Samus)
Former United Nations Space Command soldier, Samus Aran, now serves as a mercenary hunting down whatever someone pays her to hunt. Things get insane when she gets a mission to find and kill a person known as Commander Shepard by the group called Cerberus.
Season 4 (Apocalypse)
The zombie virus has decimated the world as Joel and Ellie explore this now wastelandish world filled with zombies and hostile humans.
Franchises and Continuity
For the first few seasons, War of Games uses characters from game franchises that are considered "realistic" and have the genre of action-adventure, science fiction, drama and even some fantasy elements like Uncharted, Call of Duty, Medal of Honor, Grand Theft Auto, Resident Evil and others. But that doesn't necessarily mean that characters from games such as Outlast, Heavy Rain, and more can't coexist.
Side note, some characters that're supposed to be dead in their games do appear in this series. As such, not all the original continuities mashed-up together in a universe are the same as what they were. Due to the overlapping timelines of the game franchises that exist together as well, several modifications to the timeline of the game will be made. Some timelines from some games don't always apply, as well. Even characters originating from different franchises don't always have their supposed timeline being fully implemented to the universe. The main point is: not everything that happened in one's game franchise happened in the WoG world in the season.