"Two Heads are Awesome than One!!" is the second episode of The Cartoon-Cartoon Show! from season one.
After playing around with The Professor's gene splicers, Buttercup and Ronnie get morphed together into an orange monster.
- Ronnie Anne Santiago
- Bobby Santiago
- Professor Utonium
- Lincoln Loud (Mentioned)
- Lisa Loud
- SpongeBob SquarePants (Cameo)
- Patrick Star (Cameo)
- Squidward Tentacles (Cameo)
- Bunnie (first appearance)
PlotThe episode starts off as Bobby Santiago to the Powerpuff Girls home in Townsville to drop off his sister, Ronnie to hang out with Buttercup.
Trivial & Goofs
- This is the many of times that Nickelodeon and Cartoon Network collaborate for an episode of "The Cartoon-Crossover Show!".
- This is the fourth-time that's both the cast & crew of both "The Loud House" and "The Powerpuff Girls" 2016 Reboot worked together on an episode.
- Blossom references the 1986 American science-fiction horror film "The Fly".
- This episode is the "spiritual successor" to "Crazy Mixed-Up Puffs" from the original series.
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