Trauma Center: Under the Knife 3 is an upcoming simulation adventure game created by Atlus aired in the winter of 2026.
Several years past (from the development of New Blood) and now the current year of 2040, Dr. Robert Hoffman has retired and Derek Stiles will still take Hoffman's place. Derek's cousin, Harriet Stiles, is now in the medic team helping Derek perform surgeries.
- K'Maya Smith - Dr. Harriet Stiles
- Yuri Lowenthal - Dr. Derek Stiles
- Wendee Lee - Angela "Angie" Thompson
- TBA - Dr. Robert Hoffman
- TBA - Dr. Naomi Kimishima