The Autobots arrive at Earth after the war in Cybertron ended up in a massive problem as they end up to form a bond with a teenage girl who attempts to keep their existence a secret. When their arch-enemies, the Decepticons, arrive on Earth, they have to keep Earth safe from them.
- Optimus Prime (voiced by John DiMaggio) - the determined leader of the Autobots who is trying to stop Megatron from taking over Earth and eventually to find a way to return to Cybertron as soon as they could.
- Bumblebee (voiced by Ben Schwartz) - an eager young Autobot who is often considered by Optimus to be his most trusted ally and, despite his occasional goofiness, he's pretty reliable and friendly.
- Arcee (voiced by Kat Cressida) - TBD
- Jazz (voiced by Khary Payton) - a slick Autobot who TBD.
- Hound (voiced by Brian Bloom) - TBD
- Ratchet (voiced by Rodger Bumpass) - a medical Autobot who is usually grumpy and believes that TBD.
- Martha Rein (voiced by Lacey Chabert) - a rather optimistic teenage girl who finds out the Autobots and befriends them, helping the group to keep their existence a secret.
- Ultra Magnus (voiced by Dwight Schultz) - TBD
- Sentinel Prime (voiced by Mark Hamill) - TBD
- Ironhide (voiced by Keith Ferguson) - TBD
- Julio Fox (voiced by Antony Del Rio) - Martha's rather intelligent best friend who usually tries to help her TBD.
- The Dinobots, consisting of:
- Megatron/Galvatron (voiced by Christopher Corey Smith) - the vicious leader of the Decepticons who is out to take over the entire world and to put it in his own image.
- Starscream (voiced by Richard Steven Horvitz) - Megatron's traitorous second-in-command who is out to overthrow him and take control of the Decepticons.
- Soundwave (voiced by Crispin Freeman) - TBD
- Shockwave (voiced by Jim Meskimen) - a logical Decepticon who shows barely TBD.
- Devastator (voiced by Steven Blum) - TBD
- Bludgeon (voiced by TBD) - TBD
- Slipstream (voiced by Grey Griffin) - TBD
- Frenzy (voiced by TBD) - TBD
- Blitzwing (voiced by David Sobolov) - TBD
- Barricade (voiced by TBD) - TBD
- Unicron (voiced by Alfred Molina) - TBD