The Powerpuff Girls will be a video game released in 2016 for the PS4 and Xbox One. It will be developed by Rocksteady.
- Cathy Cavadini - Blossom
- Tara Strong - Bubbles
- E.G. Daily - Buttercup
- Tom Kane - Professor Utonium, HIM, Stanley Whitfield
- Roger L. Jackson - Mojo Jojo, Butch, Pickloids
- Tom Kenny - Mayor, Narrator, Snake, Arturo, Mitch, Pickloids, Vallhalen, Disgruntled Postman, Snowman
- Jennifer Hale - Ms. Keane, Princess Morbucks, Sedusa
- Jennifer Martin - Sara Bellum
- Jeff Bennett - Ace, Broccoloids, Big Billy, Grubber, Pickloids
- Jim Cummings - Fuzzy Lumpkins
- Jack Black - The Gnome
- Chuck McCann - Amoeba Boys
- Rob Paulsen - Brick, Boomer, Blah-Blah Blah-Blah, Major Glory
- Dee Bradley Baker - Pickloids
- Ringo Starr - Fibonacci Sequins
- Frank Welker - Monkeys, Krunk, Minotaur
- Kevin Michael Richardson - Boogie Man
- Main Story: Mojo Jojo had taken a Chemical X plant and added monkey fur and bananas so everybody will become intelligent primates.
- Seduction: The Powerpuff Girls hear someone attracted to Sedusa and beat Sedusa up.
- Twin Brothers: The Amoeba Boys divide into many.
- Learning: At Pokey Oaks Kindergarten, the Powerpuff Girls learn Math, ELA, Science and History.
- Ruling the City: The Gnome appears to people to grant their wishes and somewhat end up as a ruler of the city.
- Being Green: The Gangreen Gang intend to change people into green skinned people.
- Rowdy and Ruff:
- Spooky Funk:
- Alien Invasions (DLC): The Pickloids and Broccoloids somewhat joined forces to invade Townsville.
- Butch (DLC)
- Brick (DLC)
- Boomer (DLC)
- Mojo Jojo (Challenge Mode/DLC)
- HIM (Challenge Mode/DLC)
- Princess Morbucks (Challenge Mode/DLC)
- Sedusa (Challenge Mode/DLC)
- Fuzzy Lumpkins (Challenge Mode/DLC)
- Ace (Challenge Mode/DLC)
- Big Billy (Challenge Mode/DLC)
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