The Mysterious Mysteries of Mystery Manor is an American animated mystery-supernatural-comedy television series, being created by Doug Langdale. It is produced by Cartoon Network Studios and it has aired on Cartoon Network from October 16th, 2015 until March 27th, 2021.
A brother and sister along with their sarcastic talking cat move into a mysterious mansion in Blackburrow, North Dakota, being filled with supernatural beings and new friends.
- Franklin "Frank" Woodson (voiced by Josh Keaton) - a geeky and intellectual teenager who moves in with Emma to Mystery Manor as he highly doubts the supernatural, with his doubts soon being instantly shattered when he encounters various things that can't be explained by science.
- Emily "Emma" Woodson (voiced by Cissy Jones) - an athletic and sometimes competitive teenager who is Frank’s sister as she instantly believes in the supernatural and loves being on the top on several things.
- Tyler Macabre/Tyler the Cat (voiced by Yuri Lowenthal) - the original owner of the Manor who was cursed into becoming a cat as he is forced to join Frank and Emma's adventures, being extremely sarcastic.
- Professor Evan Woodson (voiced by Liam O'Brien) - Frank and Emma's mysterious yet friendly uncle who is an expert on the supernatural as he bought Mystery Manor to see what secrets it holds.
- Tiffany Macabre (voiced by Kath Soucie) - the maid of the Manor who was around when Tyler originally owned it due to being his niece as she can be seen as somewhat stoic but can lighten up at times.
- Ghosty (voiced by Nolan North) - an idiotic ghost who was Tyler's best friend as he now lives in the manor as a ghoul.
- Doris (voiced by Tara Platt) - a giant tentacle monster that resides in the kitchen of Mystery Manor as she serves as the cook and surprisingly has a romantic past with Tyler.
- Brad Cunningham (voiced by Will Friedle) - an extremely kind student at Frank and Emma's school who Emma has a crush on that she doesn't want to admit.
- Kristen Willis (voiced by Stephanie Lemelin) - a somewhat anger-prone teenager who often bullies Frank, although it is due to her having somewhat of a crush on him.
- Principal Bob Harrison (voiced by Rodger Bumpass) - the principal of Frank and Emma's school who attempts to get the students to like him as he surprisingly considers Frank to be a friend.
- Mayor Sam Mann (voiced by TBD) - the mayor of Blackburrow who is revealed to be old friends with Evan as he is completely oblivious to the supernatural.
- The Black Queen (voiced by Jennifer Hale) - an ancient and villainous queen who resides inside the basement as she wants to break free.
- The Black Knight (voiced by TBD) - the Black Queen's loyal Knight who believes himself to be a Knight of old as his blade is actually enchanted.
- Theo (voiced by John DiMaggio) - an evil yet idiotic imp who constantly attempts to cause chaos in Mystery Manor, although he is seen as a nuisance to everyone.
- The Screecher (voiced by [kinda feral-insane]) - a hideous bat-like monster that resided inside of Mystery Manor's attic as it despises people that annoy it.
- Chelsea (voiced by Ashley Johnson) - a mysterious new student who Frank gets instantly smitten with as she is revealed to be a siren from Mystery Manor's lake who pretends to be a human to get slaves.
- The Deal Maker (voiced by [shady]) - a slick and manipulative demon who makes deal with people in order for him to get a part of their souls as he resides inside of an old video game console.
- Jestro (voiced by TBD) - a ghostly jester who resides in the Manor and wants to forcefully turn everyone happy and full of joy.
- The Snorgglefish (voiced by TBD) - a gigantic fish who resides in Lake Blackburrow and has been attacking ships.
- Mirror Maiden (voiced by TBD) - a woman who resides inside of a mirror as she wants to break free of the mirror and find a human body.
- Alister Wilde and James Luncheon (voiced by TBD and TBD, respectively) - two world famous magical debunkers who are Frank's idols as when they learn about the Manor they decide to try to take it over and turn it into a tourist trap.
The animation for the series is outsourced to Rough Draft Studios in Seoul, South Korea.
- According to the series, Frank and Emma are 16, Tyler is 3 (28 in cat years, although he's actually 222), Professor Woodson is 48 and Tiffany is ?? (although she's physically 34).
- The show, by far, has the longest title out of every other Cartoon Network show.
- Cartoon Network Studios: The custom animation is Frank, Emma and Tyler shoving a paranormal arm down a closet, then sighing in relief after successfully locking it out.