The Mighty Mutanimals is a CGI Nickelodeon cartoon series which starts as a spin-off series from TMNT 2012.
It is loosely based on an old spin-off comic with the same name.
The Turtles needed a new, more effective weapon to combat the Kraang an evil Mutants, so they decided to put together a team of powerful good mutants.
- Mighty Mutanimals
- Leatherhead (Peter Lurie) - Leader of the Mighty Mutanimals.
- Spike/Slash (Corey Feldman) - Enforcer. He and Leatherhead have a Leo and Raph arguable relationship.
- Newtralizer "Newtie" (Danny Trejo) - Weapons specialist. After that betrayal with Slash, he has gained a new energy form from the teleporter which he can change to at will. He sees how heartless he was and promises to make a better of himself.
- Martin Milton/Sir Malachi (Paul Reubens) - Diversion Artist and Mystic. He has somehow gained limited legitimate magical powers.
- Dr. Tyler Rockwell (Tom Kenny) - Acrobat. With a device Donnie created, he can now speak and sounds like Gibson from Super Robot Monkey Team Hyper Force Go!
- Pete The Pigeon (A.J. Buckley) - Aerial Specialist. He is not as brave as his teammates, but is still a kindhearted mutant who is always willing to help others in need. He is also obsessed with bread, which acts as a source of humor for Slash and Mondo because they enjoy teasing him with it. He is given a pair of shoulder-mounted laser blasters by Donnie.
- Mondo Gecko (Ben Schwartz) - Short Lizard Skateboarder with big head.
- Karai - Master Splinter's biological daughter turned into a shape shifting snake mutant.
- The Ninja Turtles
- Leonardo "Leo" (Seth Green) - The Leader
- Donatello "Donnie" - The Brains
- Raphael "Raph" - The Muscle
- Michelangelo "Mikey" - The Wild One
- April O'Neil - The Half Human Half Kraang Teenager
- Casey Jones (Josh Peck) - Hockey Vigilante
- Timothy/The Pulverizer/Mutagen Man (Roger Craig Smith) - The Turtles biggest fan.