Mickey Mouse in Action is a coming up with hand-drawn animation and live-action movie. It's like Who Framed Roger Rabbit? (1988 film), Space Jam (1996), The Adventures of Rocky and Bullwinkle (2000) and Looney Tunes Back in Action (2003).
Once upon a time in Los Angeles, California, Mickey Mouse and his friends are his girlfriend Minnie Mouse, Goofy, Donald Duck, Daisy Duck and Pluto are getting ready for their own vacation time and they are on the plane around the states to see everywhere in Florida, where they meet Rodney Dom "Marceos" R. Nicewater (played by Ewan McGregor) a man who is a special fan of the Mickey Mouse gang and he has been watching their shows a lot of times. In the studio's inside during the reunion, Mickey and his gang have meet Herve Goldfield (played by Bill Pullman) and his third daughter, Madison Goldfield (played by Raffey Cassidy) and they are on the stage to host the CEO of the animation studios about Walt Disney.
After the host, Herve and Madison has finally meet Mickey Mouse and Friends and they want to be part of the cast. During the reunion, Rodney Dom "Marceos" has meet a beautiful woman named Mayah Kath "Fernalinbe" H. Reinford (played by Piper Perabo) as he tries to ask her out on a date but she recognized to him ever since when they were teenagers, he keeps bottling her to hang out with him and she keeps telling him to leave her alone as Mayah Kath "Fernalinbe" walk away from Rodney Dom "Marceos", Mickey said Minnie has got to help her about romance.
One morning, Herve and Madison were having breakfast together then suddenly, Svenalita Blokovsky (played by Emma Stone) and Yorik Svetlinov (played by Alec Baldwin) came and they grabbed Herve as they just wanted to sack him and left Madison behind. When those villains carry Herve away from his home, Rodney Dom "Marceos", Donald, Daisy and Goofy came and see Madison is crying, because her father has been captured by those two people. R.D. Marceos realize that Herve‘s business rivals, Mr. Charles Emile "Chuck" Priecelys sent his henchmen to kidnap him so he needs him to find a blue lion diamond.
Marceos, Madison, Donald, Daisy and Goofy get in the car and started driving to Miami to the headquarter and meet Mr. Sampson (played by Eddie Murphy) and he knows about what's happening in this when Madison’s father has been captured by Mr. Priecelys to help him to find the blue lion diamond, Donald asked Mr. Sampson why’d Mr. Priecelys wants the diamond for? Mr. Sampson told him, Marceos, Madison, Daisy and Goofy that the blue lion diamond is the key to turn people into lions and he has the king of diamond card for the key so Marceos, Madison, Donald, Daisy and Goofy must find location with the card help to find it immediately. Actually they bumped into Dumbo and he said to Marceos and the gang that Walt Disney died in 1966 Marceos actually riplied to dumbo I know. at the diner there was a cameo appearance name Wowser the dog (Mark Hamill) and Proffesor Dingy (Bob Bergen).
Meanwhile Fernalinbe came to the Goldfields house and can’t find Herve and Madison anywhere but she had only found Mickey, Minnie and Pluto whom told her about Herve was taken by Mr. Priecelys as the goons show up and they have another plan to get the card of King of Diamond for the blue lion diamond so Fernalinbe, Mickey, Minnie and Pluto must find Marceos, Madison, Donald, Daisy and Goofy immediately. As they wanted to find the location, Marceos, Madison, Donald, Daisy and Goofy has meet Rowanson (played by Dave Goelz) and he is a working in the enterprises man.
During this convention with him, Mr. Roy Jones (played by Chevy Chase) show up and he's the only one who can see about the blue lion diamond as he calls Svenalita and Yorik and then they allowed to grab the card but Marceos, Madison, Donald, Daisy and Goofy escaped with the card and then they are being rescued by Fernalinbe, Mickey, Minnie and Pluto so they all drive away from those villains, while they were chasing them. In order to get away from those villains, they went into the spy car and asked it to take them to Betsy Smile and it’s started driving them to her immediately.
As the spy car took Marceos, Fernalinbe, Madison, Mickey and the gang to Betsy Smile (played by Holly Hunter) as she the one who has the card of King of Diamond and she heard that Mr. Sampson told them that Mr. Priecelys wanted Mr. Goldfield to help him to find the blue lion diamond so he can use it to turn the world but him into lions. Mickey, Donald and Goofy didn’t realize about that and how are they going to stop this. Betsy told them that the plan is to make up their way to destroy the diamond to the humanity first the card of King of Diamond has a face from “The Scream” which it’s located in the capital of Germany.
Marceos, Fernalinbe, Madison, Mickey and the gang traveled to Germany by plane as they were decided to dress like Germans and they went to the museum and see the scream as they discover the card contains a viewing window, and looking through it, the window reveals that the Scream has a map of Africa hidden beneath.
In the Eiffel Tower of France Svenalita and Yorik can’t find the heroes anywhere as the flying elephant scare them as they were doing to tell tome their ally Sigmund "Budddy" J. Yelkin (played by Ben Stiller), Mr. Priecley's friend and assistant and Pete, Mickey's rival as they told them that they know where are the heroes are so they show them the map of Africa as they All have a plan but Pete told the other spies that he works with Prieceley to help him to take over the world to use the blue lion diamond to turn these people but him into lions.
Meanwhile in Africa, Marceos, Fernalinbe, Madison, Mickey and the gang are walking in the jungle as they see Dumbo the Flying Elephant, Timothy Q. Mouse, and Mrs. Jumbo whose gave the gang a lift to get them to the lion temple as they were just found the blue lion diamond. Timothy and the elephants reveal themselves to be Mr. Priecley (played by Harold Ramis), Buddy, Svenalita, Yorik and Pete in disguise. Mr. Priecley was the crime for kidnapping Madison‘s father and plans to steal the diamond from the heroes. Madison asked Mr. Priecley, where’s her father, while they were searching for the diamond they just periling on so Mr. Jones and Rowanson carries Herve (who’s been tied up) to them.
Mr. Priecley order Marceos, Fernalinbe, Madison, Mickey and the gang to hand him the diamond or Mr. Goldfield will fall into the lava. The gang should have an idea in order to free Madison‘s father, they must use the diamond to turn him into a lion and they did. Herve is now a lion so he can scare Mr. Jones and Rowanson away. Everyone started battling the diamond to see which one who can get it. Donald have accidentally tripped over the log and then use the diamond to turn Fernalinbe, Mickey and Minnie into cave people and then he and Daisy got turned into eggs with duck feet. Goofy and Madison then fight over with Svenalita and Yorik as they began to beat them up, but Mr. Prieceley told them that the machine will turning victims into mindless, unbrave, silly and unknowing humanoid fruits if they don’t hand him the diamond.
Marceos have an idea so he used the diamond to turn Pluto into Tyrannosaur Rex and then he eats Mr. Prieceley. After that, Marceos use the diamond again to turn Fernalinbe, Mickey, Minnie, Pluto, Donald, Daisy and Herve back to their normal selves again and then they all destroy the diamond by one of the toon things while Goofy and Madison thows something on Mr. Prieceley's fruitilization machine and all the agents (a strawberry, an apple, a peach, a banana, a blueberry and an orange) turns back to their human selves and everyone are free.
Back in America, Buddy, Mr. Jones, Rowanson and Pete are arrested for doing the revenge plot and Madison is so glad to have her father back and she thanked Marceos, Fernalinbe, Mickey and the gang for saving her father and the announcer Jason Alexander who is announced that Charles Prieceleys, Ivanvitch Svetlinov and Svenalita Blokovsky were been defeated by Mickey and the gang alongs with Rodney-Dom/Marceros and Mayah-Kath/Fernalinbe whose decided to go on a date and also Madison and Herve have got back to their father and daughter time.
As for Mickey Mouse and Friends, they head back to Hollywood and they lived happily ever after!
- Kieran Glen Harris Stark (in Mickey Mouse voice) as Mickey Mouse
- Cindy Robinson (in Minnie Mouse voice) as Minnie Mouse
- Mitchell Kuester (in Donald Duck voice) as Donald Duck
- Kieran Glen Harris Stark (in Daisy Duck voice) as Daisy Duck
- Glen Campbell (in Goofy voice) as Goofy
- Roger Craig Smith (in Pluto voice) as Pluto
- Bob Brians (in Peg-Leg Pete voice) as Peg-Leg Pete
- Ben winshaw (in dumbo voice) as dumbo
People in Live-Action
- Ewan McGregor as Rodney Dom "Marceos" R. Nicewater, a man who can help Mickey, Minnie, Donald, Daisy, Goofy and Pluto to save the world.
- Harold Ramis as Mr. Chuck Priecelys a villain who worked with Pete
- Piper Perabo as Mayah Kath "Fernalinbe" H. Reinford, a woman who also helped Mickey, his friends and R.D. she falls in love with.
- Raffey Cassidy as Madison Goldfield, a girl who lost her father because he was kidnapped by those villains so Mickey and his friends must help her find her father.
- Bill Pullman as Herve Goldfield, Madison's father who got kidnapped by those villains.
- Eddie Murphy as Mr. Sampson a man who is responsible to need the trio to help Mickey and his friends.
- Emma Stone as Svenalita Blokovsky, Mr. Priecelys's henchwoman who help him and Pete to take over the world.
- Alec Baldwin as Ivanvitch "Yorik" Svetlinov Mr. Priecelys's henchman who also help him and Pete to take over the world.
- Chevy Chase as Mr. Roy Jones the two spies's boss who works with Mr. Priecelys and Pete.
- Holly Hunter as Betsy Smile a woman who is a good friend of a man, a woman and a girl.
- Dave Goelz as Rowanson another man who was working in this enterprises.
- Ben Stiller as Sigmund "Buddy" Yelkin Mr. Prieceley's henchman
- Jason Alexander as the announcer
- Bob Bergen as Professor Dingy
- Mark Hamill as Wowser the Dog