Voice Cast[]
- Tara Strong as Cady Heron
- Kari Wahlgren as Regina George
- Mae Whitman as Gretchen Weiners
- Ashley Johnson as Janis Ian
- Jessica DiCicco as Karen Smith
- Grey DeLisle as Ms. Sharon Norbury
- Phil LaMarr as Mr. Ron Duvall
- Josh Keaton as Aaron Samuels
- Rider Strong as Damian Leigh
- Laraine Newman as Mrs. George
- Aimee Mann as Betsy Heron
- Maurice LaMarche as Chip Heron
- Jon Heder as Jason
- Billy West as Kevin Gnapoor
- Adam McArthur as Shane Oman