From 2004 to 2012, Laurie played Dr. Gregory House, the title character of House, for which he received two Golden Globe Awards and two Screen Actors Guild Awards. He was listed in the 2011 Guinness World Records as the most watched leading man on television and was one of the highest-paid actors in a television drama, earning £250,000 ($409,000) per episode of House.
Laurie has portrayed Senator Tom James in the HBO political satire Veep since 2015, as well as Dr. Eldon Chance in the Hulu series Chance since 2016. In 2016, he appeared in the BBC/AMC miniseries The Night Manager, receiving his third Golden Globe Award for Best Supporting Actor.
Laurie's debut studio album, Let Them Talk, was released to favorable reviews in May 2011. A follow-up, Didn't It Rain, was released in August 2013.