The patient is Sonic the Hedgehog, the doctors must do surgery to destroy the parasite located in his heart before it corrupts him.
The episode begins in Dr. Eggman's lair as he is thinking of a new plan to destroy Sonic the Hedgehog. He tracked his location that he and Tails landed in the city of Portland, he and his sidekicks makes some preparations to destroy Portland.
- Chelsea Tavares - Dr. Brenda Young
- Hailee Steinfield - Dr. Jennifer Powell
- Dylan Minette - Dr. Ralph Morris
- Dante Brown - Dr. Xavier Carter
- Jake T. Austin - Dr. Carlos Gonzalez
- Saoirse Ronan - Evie Hughes
- Ken Jeong - Lester Chen
- Dee Bradley Baker - ABION (Artificial Brisk Intelligent Operation Networker)
- Roger Craig Smith - Sonic the Hedgehog
- Colleen Villard - Miles "Tails" Prower
- Mike Pollock - Dr. Eggman
- Kirk Thornton - Orbit
- Wally Wingert - Cubot
- In this episode, Amy and Knuckles were mentioned but did not appear.