His Boss Battle in the game is extremely complex compared to various games with him as the boss.
His boss fight is a combination of his boss battles from Marvel vs. Capcom 3, Marvel Ultimate Alliance and LEGO Marvel Super Heroes.
All of his moves from Marvel vs. Capcom 3: Fate of Two Worlds were recycled for the game.
- "I am Galactus. My powers are limitless and in all of the universes is nothing I can't do." - his first monologue before the final boss battle
- "I, the mighty Galactus, You Young Pirate boy from an Island, SHALL BE DEAD FOR ONCE AND FOR ALL FROM THE MIGHTY GALACTUS!!!!!!!!!!" - to Captain Jake/Werewolf Jake
- "Well, well looks like a brave and heroic Princess from an another dimension that has a magic wand to defeat me, the MIGHTY GALACTUS???!!!! HA! YOU'LL NEVER DEFEAT ME MY LADY!!!!!!" - to Star Butterfly
- "Ha! An old adventurer? It's time for you to be defeated BY THE MIGHTY GALACTUS!!!!!!!" - to Indiana Jones
- "An another brave and heroic princess from an another dimension but this time as a squirrel? HA! YOU'LL NEVER DEFEAT THE MIGHTY GALACTUS!!!!!!" - to Sally Acorn
- "A heroic warrior from Outer Space? HA!!! YOU'LL NEVER VANQUISH ME, THE MIGHTY GALACTUS!!!!!" - to heroic space characters like Star-Lord, Luke Skywalker, Han Solo, etc.
- "A fast guy, HA! YOU'LL NEVER STOP THE MIGHTY GALACTUS!!!!!!" - to fast male characters such as Sonic the Hedgehog, Barry Allen/The Flash and Pietro Maximoff/Quicksilver
- "The Invincible Iron Man, YOU'LL NEVER STOP THE MIGHTY GALACTUS!!!!!!" - to Iron Man
- "Mighty Thor, YOU'LL NEVER STOP ME, THE MIGHTY GALACTUS!!!!!!!" - to Thor
- "Deadpool, YOU'LL NEVER VANQUISH ME!!!!!!" - to Deadpool
- "An another Thor? HA!!!! THE MIGHTY GALACTUS WILL DESTROY YOU!!!!!" - to Amy Rose/Jane Foster/Thor
- "Iron Fist? (Evil laughs loudly) YOU'LL NEVER STOP ME!!!!!!" - to Marco Diaz/Iron Fist
- "To perform your task as my herald, you little bandit, you must become far more than just a man."
- "My Herald, the hunger is upon me."
- "YOU'LL NEVER STOP ME!!!!!" - when he is getting weaker
- "YOU DARE YOU DEFEAT THE MIGHTY GALACTUS???!!!!!" - when he gets killed
- In the Japanese dub of the game, Toshio Furukawa, known for voicing Piccolo voices him whilist John DiMaggio reprise his role as Galactus in the English counterpart.
- One of his quotes against the playable characters,