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The following villains are considered the main antagonists of the story in which they appear. That is to say the most prominent, influential and powerful of all, the one at the center of the conflict, whose importance in the plot outshines all.

List of the main antagonists of both the canon and fanon media

Marvel Cinematic Universe

Infinity Saga (Phases 1 — 3)

  • Thanos is the main antagonist of the Infinity Saga of the Marvel Cinematic Universe, serving as the main antagonist of both Avengers: Infinity War and Avengers: Endgame, the last two installments of The Avengers film quadrilogy.
Phase One
  • Obadiah Stane / Iron Monger is the first main antagonist of the phase, serving as the main antagonist of Iron Man, the first installment of the solo film trilogy of the same name. He is also the first main antagonist of the trilogy and the saga.
  • Emil Blonsky / Abomination is the main antagonist of The Incredible Hulk.
  • Ivan Vanko / Whiplash is the main antagonist of Iron Man 2, the second installment of the solo Iron Man film trilogy.
  • Loki Laufeyson is the main antagonist of both Thor, the first installment of the solo film trilogy of the same name, and The Avengers, the first installment of the film quadrilogy of the same name. He is also the first main antagonist of both the solo Thor film trilogy and The Avengers film quadrilogy.
  • Johann Schmidt / The Red Skull is the main antagonist of Captain America: The First Avenger, the first installment of the solo Captain America film trilogy.
Phase Two
  • Aldrich Killian is the first main antagonist of the phase, serving as the main antagonist of Iron Man 3, the third and final installment of the solo Iron Man film trilogy. He is also the second-to-first main antagonist of the saga.
  • Malekith the Accursed is the main antagonist of Thor: The Dark World, the second installment of the solo Thor film trilogy.
  • Alexander Pierce is the main antagonist of Captain America: The Winter Soldier, the second installment of the solo Thor trilogy.
  • Ronan the Accuser is the main antagonist of Guardians of the Galaxy, the first installment of the film duology of the same name.
  • Ultron is the titular main antagonist of Avengers: Age of Ultron, the second installment of The Avengers film quadrilogy.
  • Darren Cross / The Yellowjacket is the main antagonist of Ant-Man, the first installment of the film duology of the same name.
Phase Three
  • Helmut Zemo is the first main antagonist of the phase, serving as the main antagonist of Captain America: Civil War, the third and final installment of the solo Captain America film trilogy. He is the third-to-first main antagonist of the saga.
  • Kaecilius is the main antagonist of Doctor Strange.
  • Ego the Living Planet is the main antagonist of Guardians of the Galaxy Vol. 2.
  • Adrian Toomes / Vulture is the main antagonist of Spider-Man: Homecoming, the first installment of the MCU solo Spider-Man film duology.
  • Hela Odinsdottir is the main antagonist of Thor: Ragnarok, the third and final installment of the solo Thor film trilogy.
  • Erik Killmonger is the main antagonist of Black Panther.
  • Ava Starr / Ghost is the main antagonist of Ant-Man and the Wasp, the second and final installment of the solo Ant-Man film duology.
  • The Supreme Intelligence is the main antagonist of Captain Marvel.
  • Quentin Beck / Mysterio is the main antagonist of Spider-Man: Far From Home, the second and final installment of the MCU solo Spider-Man film duology.

Upcoming phases

  • Xer Pettingill is the overall main antagonist of the Jaxon Borsellino solo franchise, serving as the overall main antagonist of the two-half film Action Jaxon (serving as the main antagonist of The First Half, and later as one of the two secondary antagonists (alongside Commander Golden-Armorous) of the sequel The Second Half.), and its television series sequel Action Jaxon: The TV Series.
  • Rednax Notlehs / The Red Machine is the overall main antagonist of the Xander Shelton solo franchise and its solo film series, serving as the main antagonist of The Green Machine, and later as one of the two main antagonists (alongside Christina Black) of the sequel The Green Machine II.

Star Wars universe

  • Emperor Palpatine / Darth Sidious is the main antagonist of the Star Wars franchise.

Three trilogies

Original (IV — VI)
  • Grand Moff Tarkin is the first main antagonist of the trilogy, serving as the main antagonist of A New Hope, the first installment of the trilogy.
    • Darth Vader is the main antagonist of The Empire Strikes Back, the second installment of the trilogy.
    • Emperor Palpatine / Darth Sidious is the main antagonist of Return of the Jedi, the third and final installment of the trilogy.
Sequel (VII — IX)
  • Ben Solo / Kylo Ren is the first main antagonist of the trilogy, serving as the main antagonist of both The Force Awakens and The Last Jedi, the first two installments of the trilogy.
    • Emperor Palpatine / Darth Sidious is the main antagonist of The Rise of Skywalker, the third and final installment of the trilogy.

The Revenge of the Evil Spirit film duology

  • Emperor Satan / Darth Devil is the titular main antagonist of all two installments of the whole duology.

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