Brandy & Mr. Whiskers is a American 3D animated comedy from Walt Disney Animation Studios. It is based on the short-lived TV series of the same name. The movie follows a dog named Brandy Harrington and a rabbit named Mr. Whiskers getting stranded in the jungle and trying to get home. The original voice cast from the television series returns for the movie.
Brandy Harrington, of the Florida Harringtons, is a pooch with an undeniable love for fame and luxury. Mr. Whiskers is an insane little rabbit who tends to get into big messes. The second they met on a plane, it spelled trouble. They fell out of the plane and landed in the jungle! Now Brandy and Mr. Whiskers have to find a way to get back home, while making friends and enemies along the way!
- Kaley Cuoco as Brandy Harrington, a dog and one of the main protagonists
- Charlie Adler as Mr. Whiskers, a rabbit and one of the main protagonists
- Alanna Ubach as Lola Boa, a boa constrictor
- Sherri Shepherd as Cheryl and Meryl, twin toucan sisters
- Tom Kenny as Ed, a giant otter
- Andre Sogluizzo as Gasper Le Gecko, the main antagonist
- Jennifer Hale as Margo, a stick bug
- Dee Bradley Baker as Harold, Mr. Whiskers' pet Guinea pig
- Grey DeLisle as Gabriella, Gasper's girlfriend
- Tara Strong as the Lemur, a friend of Margo and Gabriella
- The film serves as a revival of the original TV series that also delivers the conclusion that the show could never give due to its cancellation.