- Joshua “Josh” Dela Cruz - Josh, the host of the series.
- Blue - (voices by Traci Page Johnson, Chris Brown, Tyga, Wiz Khalifa, DJ Khaled, T.I., Young Dro, Sean P, Lonnie Mac, Ludacris, Willie the Kid, Trey Songz, Triple C's, CTE World, Doughboyz Cashout, Kid Ink, Gucci Mane, La the Darkman, Yung Joc, Bun B, Flo Rida, Mike Jones, Rick Ross, Trick Daddy, Ray J, Akon, Birdman, Lil Wayne, Nicki Minaj, Tyga, Mack Maine, Limp Bizkit, Bow Wow, Ace Hood, Moussa Assuom, Jae Millz, Cory Gunz, Gudda Gudda, Caskey, Detail, Busta Rhymes, Mystikal, Future, Meek Mill, French Montana, Yo Gotti, The Game, Kendrick Lamar, and R. Kelly. Fabolous, Yo Gotti, OJ da Juiceman, Nas, Scarface, Marsha Ambrosius, The-Dream, Too Short, Styles P, Jovan Dais, Snoop Dogg, B.G., Juvenile, with Soulja Slim, Drumma Boy, Tricky Stewart, Cordale "Lil C" Quinn, Dijon Isaiah McFarlane, Kevin Hart, Kat Williams, Ty Dolla $ign, Migos, and travis scott), Drake, The Weeknd, Future, Sean E. Combs, Pitbull (rapper), Kanye West, ScHoolBoy Q, and other 106 and park casts members and rap artists with nick cannon and nick cannon presents wild n out rap artists) A blue puppy.
The animated characters Magenta, Tickety-Toc, Slippery Soap, Shovel, Pail, Mrs. Pepper, Mr. Salt, Paprika, Cinnamon, Sidetable Drawer, and Mailbox from the original series will return in the new show and all animated characters will all be voices by: Seth MacFarlane, Alex Borstein, Seth Green, Lacey Chabert, Mila Kunis, Mike Henry, Dan Castellaneta, Julie Kavner, Nancy Cartwright, Yeardley Smith, Hank Azaria, Harry Shearer, Rachel MacFarlane, Trey Parker and Matt Stone.
|Produced by||Kevin Feige|
Music By; Trey Parker and Matt Stone