This is the third and final chapter of Big Hero 6 trilogy.
- Hiro Hamada (voiced by Ryan Potter) Jessica's father and Gogo's boyfriend.
- Baymax (voiced by Scott Asdit)
- Spider-Man (voiced by Tom Holland)
- Jessica Hamada, Hiro and GoGo's daughter (voiced by Colleen Evans)
- Little Jessica Hamada (voiced by Kristen Bell)
- GoGo Tomago (voiced by Jaimie Chung) Hiro's girlfriend and Jessica's mother.
- Honey Lemon
- Fred (voiced by T.J. Miller)
- Alistair Krei
- Aunt Cass (voiced by Maya Rudolph)
- Black Widow (voiced by Scarlett Johannson)
- Silver Sable
- Salma Hayek as Tanya, Tadashi's girlfriend ever since sixth grade.
- Doctor Octopus (voiced by Alfred Molina)
- Mysterio (voiced by Seth MacFarlane)
- Mary Jane Watson (Flashbacks)
- Aunt May (Flashbacks)
- Nick Fury (voiced by Samuel L. Jackson)
- J. Jonah Jameson (voiced by J.K. Simmons)
- This film is based on comic "Amazing Spider-Man Vol 1 685"
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