In San Francisokyo, a small group of teenagers decide to form a superhero team out to defend it from various threats and menaces.
- Hiro Hamada - a Japanese-American teen prodigy who forms a team of heroes to stop evil and TBD.
- Baymax - a protective robot created to serve anyone who is in need, being used as mode of attack against several dangerous TBD.
- Wasabi-No-Ginger - a cowardly student chef who reluctantly TBD.
- Fred Fredericksen/The Silver Samurai - a lazy comic book fan who TBD.
- GoGo Tomago - a rebellious biker who joins the team to TBD.
- Honey Lemon - a mysterious yet optimistic teenager who ends up joining TBD.
- Everwraith - a mysterious and somewhat supernatural criminal who is connected to the TBD.
- Mr. Yama - a known mob boss who is feared throughout San Francsicokyo and is extremely intimidating and TBD.
- Yama is portrayed as a mob boss and is additionally responsible for supposedly killing Tadashi by burning down the college.
- The series combines elements of the original comics and the animated film.
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