The Mightypuff Girls

 is an American action-adventure-science fiction-comedy superhero comic book series based on , being published by since TBD 2017.

Synopsis
Set in a distant future in the City of Qwertysville, three teenage girls join forces to face several threats that haunt their hometown.

Main

 * Mecha Utonium - the leader of the trio and Blossom's descendant who is extremely intelligent, providing the team with her own gadgets.
 * Mena Utonium - the most beautiful but the ditziest of the trio and Bubbles' descendant who is obsessed with cute animals and fashion.
 * Meteor Utonium - the tomboyish and strongest of the trio and Buttercup's descendant who often gets into trouble due to her short temper and aggressivity.

Original

 * Hera - the Greek goddess of women who grants the girls new powers known as the Might Force and serves as a mentor to them.
 * Kurt Jocex - the editor-in-chief of the Daily Qwertz who is often at odds with the Mightypuff Girls, since he believes they are TBD.
 * Captain Archibald Russo - the head of the Qwertysville Police Department who sees the Mightypuff Girls as potential menaces due to their TBD.

Descendants

 * Prof. Chase Utonium - a scientist who is the Mightypuff Girls' creator/father and Professor Utonium's descendant, being very caring and protective of them.
 * The Mayor of Qwertysville - the Mayor of Townsville's descendant who is idiotic and obsessed with pickles, much like his ancestor.
 * Ms. Sasha Bellum - the Mayor's beautiful assistant and Ms. Bellum's descendant who assists him and occasionally gives advice to the Mightypuff Girls.
 * Ms. Kristen Keane - the Mightypuff Girls' teacher at Qwertysville High School and Ms. Keane's descendant who often provides useful info to them. It's later revealed she's dating Utonium.
 * Carolyn Snyder - the Mightypuff Girls' best friend and Robin Snyder's descendant who sometimes helps them.

Original

 * Dolores Megabytes - Duchess Megabytes' mother who is the head of Megabytes Corporation, being out to defeat anyone who gets in her way.
 * Hades - the Greek god of the underworld who has mastered the TBD.
 * Sandra Jocex/Toxica - a janitor and Kurt's sister who became a toxic being after a freak accident, causing her TBD.

Descendants

 * Mojo Jupiter - a genetically modified chimpanzee and Mojo Jojo's descendant who wants revenge on Utonium for rejecting him and turning him into a deadly mutant.
 * It - a powerful demon and Him's descendant who aims to destroy TBD.
 * Duchess Megabytes - a rich spoiled brat and Princess Morbucks' descendant who desires to be a Mightypuff Girl, even if it implies murder.
 * Lord Silico - TBD
 * Fluffy Lumpkins - a hillbilly creature and Fuzzy Lumpkins' descendant who tries to kill anyone who invades his property.
 * The Deadlyruff Boys, consisting of:
 * Blast - TBD
 * Bomb - TBD
 * Burst - TBD
 * The Cygreen Gang, consisting of:
 * Spade Copular - the leader of the Cygreen Gang and Ace's descendant who TBD.
 * Jasmine "Serpent" Ingleberry - TBD
 * Armando "Lil' Armando" de la Guerra - TBD
 * Grubtron - TBD
 * Daniel "Big Danny" Williams - TBD
 * Sedustara - a seductive medusa-like figure and Sedusa's descendant who TBD.
 * The Amoeba Gang, consisting of:
 * Extreme Leader - TBD
 * Youngster - TBD
 * Slender - TBD
 * Empress Paintina - TBD
 * Doctor Ivan Chrontech - TBD
 * The Fashionistas, consisting of:
 * [Bianca Bikini] - TBD
 * [Barbarus Bikini] - TBD

Trivia

 * This comic has a similar premise to Loonatics Unleashed.
 * Similar to it, the main characters are teenagers and Hera's role is inspired by Zadavia.
 * Rather than being toddlers like their ancestors, the main characters are 16 years old.
 * While most of the concepts are based in the 1998 series, some elements from the 2016 series are incorporated into it as well.