Osmosis Jones II: The City of Frank

Osmosis Jones II: Big Vacation (also known as Osmosis Jones 2) is a 2006 American live-action/animated action comedy film directed by the Mike B. Anderson The sequel of first part.

Plot
Ozzy and Drix became buddy police officers, their goal to protect a healthy lifestyle from any harm in the form of criminals, together, in the city of Frank DeTorre, who has already chosen a new profession to become a psychologist. Although they did not think about the safety of the city, the new mayor and his son long ago tried to avoid an age crisis, Frank drank the energy drink Jolt Cola penetrating an ingredient into the body, a caffeine.

But by the time he met by the two idiot cops, Jolt was tamed as a new ally and the word "Peace" is attached to him. But if he gets seperatly of them, the city would be in danger, because caffeine had a goal to convert a heart attack, if possible Frank drinks too much. Will Osmosis Jones the white blood cell and Drixenol the pill be able to set the most important rules for this parasite?

Live/action characters

 * Bill Murray as Frank DeTorre
 * Ethan Cutkosky as Young Frank DeTorre (late-1960s)
 * Dane DeHaan as Young Frank DeTorre (late-1970s - 1980s)
 * Tom Cruise as TBA
 * Tom Cruise as TBA
 * Tom Cruise as TBA
 * Tom Cruise as TBA
 * Tom Cruise as TBA
 * Tom Cruise as TBA

Animated characters

 * Chris Rock as Osmosis "Ozzy" Jones, an one of two protagonists.
 * David Hyde Pierce as Drixenol "Drix" Koldreliff, an one of two protagonists.
 * Jimmy Fallon as Jolt, a caffeine, but a former viral medication by ingredient from the same name product.
 * Harry Enfield as Kano Dirky, a blood cell cancer
 * Christopher DeLisle as The Osmobile, also known as Backseat, the navigation and a talking car.
 * Christopher DeLisle as The Osmobile, also known as Backseat, the navigation and a talking car.
 * Christopher DeLisle as The Osmobile, also known as Backseat, the navigation and a talking car.
 * Christopher DeLisle as The Osmobile, also known as Backseat, the navigation and a talking car.
 * Christopher DeLisle as The Osmobile, also known as Backseat, the navigation and a talking car.