Osmosis Jones

Osmosis Jones is a 2001 American live-action/animated action comedy adventure film with animated scenes directed by Tom Sito and Piet Kroon and live-action scenes directed by the Farrelly brothers. The film centers on Frank Detorre, a slovenly zookeeper; the live-action scenes are set outside Frank's body, while the animated scenes are set inside his body, which is portrayed as a city inhabited by anthropomorphic blood cells and microorganisms. White blood cell cop Osmosis "Ozzy" Jones and cold pill Drix must prevent deadly virus Thrax from killing Frank within forty-eight hours.

The film was met with mixed reviews, with critics praising the animated portions but criticizing the live-action portions and their use of gross-out humor. The film was also a box office bomb, earning $14 million against a budget of $70 million, though it later sold well in home media. It also served as the pilot to the Kids' WB spin-off television series Ozzy & Drix (2002–04), where the two main characters get transferred by a mosquito to the body of a teenage boy named Hector and continue their battle against germs and viruses from there. Unlike the film, however, the series does not contain any live-action sequences and the two leads are recast.

Plot
Frank Detorre (Bill Murray) is an unkempt, slovenly, widowed zookeeper at the Sucat Memorial Zoo in Rhode Island. Depressed by the loss of his wife Maggie years earlier, he copes by eating unhealthily and ignores basic hygiene, to the annoyance of his young daughter Shane (Elena Franklin). During a lunch break, Frank eats a boiled egg he dropped onto the ground after a chimpanzee had stolen it and put it in its mouth.

Inside Frank's body, Osmosis "Ozzy" Jones (Chris Rock), a rebellious and disgraced white blood cell officer of the Frank PD, recklessly chases germs from the egg, but fails to catch them and instead causes Frank to have a bad leg cramp. Meanwhile, facing a serious challenge to his re-election prospects, Mayor Phlegmming (William Shatner) doubles down on Frank's consumption of junk-food, despite concerns from his secretary Leah Estrogen (Brandy Norwood). Meanwhile, Thrax (Laurence Fishburne), a deadly red virus, emerges from the leftover egg and sadistically causes inflammation in the throat.

Unwilling to admit responsibility for the recent symptoms, Phlegmming instructs Frank to take a cold pill through brain signals. The suppressant, Drixenol "Drix" Koldreliff (David Hyde Pierce), is partnered with Ozzy to investigate the recent sore throat. While Drix cools off the inflammation, Ozzy gets a short eyewitness testimony from a terrified bacterium who saw Thrax arrive.

Thrax assumes leadership of a gang of sweat germs and launches an attack on the mucus dam in Frank's nose, causing a runny nose, nearly expelling Ozzy and Drix before Frank inhales them back into the sinuses. While continuing the investigation, Drix hears that Phlegmming remembers Ozzy setting the worst record in Frank's body and he doesn't want him to do the same thing when Frank planned a trip to the wing festival in Buffalo, New York. When he wonders aloud why Ozzy had a record, Ozzy reveals to Drix that two years ago, during a science fair at Shane's school, he caused Frank to publicly vomit on Shane's science and P.E. teacher, Mrs. Boyd (Molly Shannon), after seeing a deadly virus on an oyster Frank ate earlier after observing Zack's oyster display thanks to a boy telling people to look at Frank moments before he puked. The story ran in the newspaper the next day, resulting in Frank, Shane, Mrs. Boyd, and even their whole families becoming the town laughingstocks overnight causing them to be humiliated every year as well as Frank being fired from his job at the pea soup factory by his manager and supervisor after he embarrassed them. His brother and Shane's uncle Bob (Chris Elliott) later helped him get a job at the zoo, where Frank still gets zero respect. Ozzy, in turn, was then suspended from his job working in the stomach and kidneys and then demoted to patrol duty in the mouth for excessive use of unnecessary force. Ozzy tells Drix how he wonders every day if what he did was right since then. Drix, in turn, assures Ozzy that he did the right thing as raw oysters are frequently breeding grounds for potentially dangerous bacteria which is what Ozzy was trying to tell everybody.

Based on information from a vaccine virus, Ozzy and Drix go undercover at a nightclub located within a large zit on Frank's forehead, intending to infiltrate Thrax's gang. Once there, the two discover Thrax's plan to steal chromosomes from the hypothalamus, driving up Frank's body temperature and killing him in 48 hours. However, Ozzy's cover is blown and he is forced to scream for help from Drix, who destroys the club with a grenade. The explosion bursts the zit during Frank's meeting with Mrs. Boyd, causing it to land on her lip, grossing her out, and she angrily screams at him to leave. In response, a furious Phlegmming closes the investigation, fires Ozzy, and orders Drix to leave the city.

Having survived the assault, Thrax kills his last surviving gang members when they suggest waiting to attack the hypothalamus (declaring that they are themselves "incubate"), which would have meant missing his deadline, then discreetly breaks into the hypothalamus gland and steals a DNA bead from a chromosome. Frank's body temperature begins to rise. Ozzy, realizing that Thrax was still a threat, stops Drix from leaving and convinces him to come back and help him finish the case. Thrax then kidnaps Leah and flees to the uvula to escape. When Phlegmming attempts to speak with Bob, trying to convince him Frank is fine, it is useless, and Bob saying the trip to Buffalo is off as Frank is going to the hospital causes Phlegmming to scream in devastation. As Frank is taken to the hospital in a fever induced coma, with Shane (who’s been passing by with her bus for her camping trip) she and Bob jump into Frank’s car to the hospital, Ozzy and Drix give chase and save Leah, but Thrax escapes out of the mouth by using pollen, causing Frank to sneeze and expelling Thrax from his body. With Drix's help, Ozzy pursues Thrax to the surface of Shane's right eye and her false eyelash (given to her by one of her friends when she was in her bus). Thrax pins Ozzy down and threatens to kill Shane next as his newest victim, but gets stuck in the eyelash; Ozzy's pliable body allows him to escape and hang onto Shane's real eyelash as the false eyelash slides off and lands in a glass of rubbing alcohol, dissolving a screaming Thrax to death.

As Frank's temperature reaches 108 degrees, his heartbeat flatlines as he suffers hyperpyrexia, leaving Shane devastated. Riding on one of Shane's tears, Ozzy reenters Frank's body with Thrax's necklace of DNA beads, reviving Frank just in time. Having narrowly cheated death, Frank commits himself to living a much healthier lifestyle with the help of Shane, while Ozzy begins a relationship with Leah and is re-instated to the force with Drix as his new partner. Phlegmming (who is heartbroken and had now realized his actions on Frank nearly drove him to his death and that of the City of Frank as well) loses his position as mayor and is reduced to working as a custodian in the bowels. He later accidentally ejects himself from the body by pushing a button that triggers Frank's flatulence.

Animation voice cast

 * Chris Rock as Osmosis "Ozzy" Jones are you okay?, an overzealous blue and white blood cell with little respect for authority
 * Laurence Fishburne as Thrax's death, a tall, extremely virulent, pathogenic agent.
 * David Hyde Pierce as Drixenol "Drix" Koldreliff, a stoic cold pill who becomes Ozzy's best friend
 * Brandy Norwood as Leah, Mayor Phlegmming's secretary and Ozzy's love interest
 * William Shatner as Mayor Phlegmming's death, the self-centered mayor of the "City of Frank"
 * Ron Howard as Tom Colonic, Phlegmming's rival for the mayoralty of the City of Frank
 * Joel Silver as the police chief, Ozzy's boss
 * Steve Suuskind as Mob Germ Boss
 * Carlos Alazraqui as Spanish germ
 * Antonio Fargas as Chill
 * Rodger Bumpass as Announcer for Nerve News Network and Joe Cramp
 * Paul Christie as Dan Matter and Germ
 * Richard Steven Horvitz as Male Red Blood Cell
 * Kid Rock as Kidney Rock
 * James Arnold Taylor as Coffee Holding White Blood Cell (uncredited)

Live-action cast

 * Bill Murray as Frank Detorre; The animated part of the film takes place inside his body, which is referred to by the cells as "the City of Frank"
 * Elena Franklin as Shane Detorre, Frank's 10-year-old daughter
 * Molly Shannon as Mrs. Boyd, Shane's science and P.E. teacher
 * Chris Elliott as Bob Detorre, Frank's brother

Production
Osmosis Jones went through development hell during production. The animated sequences, directed by Tom Sito and Piet Kroon, went into production as planned, but acquiring both a director and a star actor for the live-action sequences took a considerable amount of time, until Bill Murray was cast as the main character of Frank, and Peter and Bobby Farrelly stepped in to direct the live-action sequences. As part of their contract, the Farrelly brothers are credited as the primary directors of the film, although they did no supervision of the animated portions of the film. Will Smith was interested in the part of Ozzy, but in the end his schedule didn't permit it.

Osmosis Jones was originally rated PG-13 for "crude language" and "bodily humor" in 2000. However, Warner Bros. edited the film to make it family-friendly, and in 2001 the film was re-rated PG for "bodily humor".

Box office
Osmosis Jones had its world premiere screening on August 7, 2001 at the Grauman's Egyptian Theatre in Hollywood, California. Shortly after that, the film widely opened on August 10, 2001 in 2,305 theaters worldwide. Upon its original release, the film was a financial stump, and was the second-to-last production for Warner Bros.' feature traditional animation department (following The Iron Giant, and followed by Looney Tunes: Back in Action, which both also lost money upon their original releases). The movie opened at #7 in its first opening weekend at the U.S. box office, accumulating $5,271,248 on its opening week while earning $2,286. The film soon grossed $13,596,911.

Reception
On Rotten Tomatoes, the film has an approval rating of 55% based on 108 reviews, with an average rating of 5.5/10. The site's critical consensus reads, "The animated portion of Osmosis is zippy and fun, but the live-action portion is lethargic." At Metacritic, which assigns a weighted average rating to reviews, the film has received an average score of 57 out of 100, based on 28 critics, indicating "mixed or average reviews". Audiences polled by CinemaScore gave the film an average grade of "B-" on an A+ to F scale.

The animated parts of Osmosis Jones were praised for their plot and fast pace, in contrast with the criticized live action segments. Robert Koehler of Varietypraised the film for its animated and live-action segments intervening, claiming it to be "the most extensive interplay of live action and animation since Who Framed Roger Rabbit". The New York Times wrote "the film, with its effluvia-festival brand of humor, is often fun, and the rounded, blobby rendering of the characters is likable. But the picture tries too hard to be offensive to all ages. I suspect that even the littlest viewers will be too old for that spit." Roger Ebertgave the film 3 stars out of 4.

The use of crude humor in the film, as seen in most films directed by the Farrelly brothers, was widely criticized. As such, Lisa Alspector of the Chicago Readerdescribed the film as a "cathartically disgusting adventure movie". Maitland McDonagh of TV Guide praised the film's animation and its glimpse of intelligence although did criticize the humor as being "so distasteful". Lisa Schwarzbaum of Entertainment Weekly felt that the film had a diverse premise as it "oscillates between streaky black comedy and sanitary instruction", however the scatological themes were again pointed out. Jonathan Foreman of New York Post claimed Osmosis Jones to have generic plotting, saying that "It's no funnier than your average grade-school biology lesson and less pedagogically useful than your typical Farrelly brothers comedy." Michael Sragow of Baltimore Sun praised David Hyde Pierce's performance as Drix, claiming him to be "hilarious" and "a take-charge dose of medicine". Despite of the mixed reviews, the film received numerous Annie award nominations including Best Animated Feature (losing to Shrek).

Soundtrack
Main article: Osmosis Jones (soundtrack)

A soundtrack containing hip hop and R&B music was released on August 7, 2001 by Atlantic Records. The soundtrack failed to make it to the Billboard charts, but Trick Daddy's single "Take It to da House" managed to make it to 88 on the Billboard Hot 100 singles chart.