An Octopus is My Best Friend

, also known as Disney's , is an American animated television series created by Catherine Uhlman. It is being created by Walt Disney Television Animation and Disney Channel Originals and aired on Disney Channel from July 2nd, 2004 until November 21st, 2008.

Synopsis
A teenage girl and her octopus best friend embark on adventures in the fictional city of Hitsonville, Michigan.

Main

 * /Shirley Mason/ (voiced by Alyson Stoner) - a teenage girl who is cheerful and very helpful and generous.
 * /Octo/ (voiced by Billy West) - an octopus who has an ability to breathe in land, as well as Shirley's best friend.

Supporting

 * Jason Mason (voiced by Gregg Berger) - a dimwitted man who is Shirley's father. Despite his stupidity, he deeply cares for his kids, and tries to make sure they are safe.
 * Drake Mason (voiced by Tara Strong) - a mischevious little boy who likes messing with his sister and Octo.
 * /Taylor Ortiz/ (voiced by Mae Whitman) - a tomboyish teenage girl who is one of Shirley's close friends, who is also very fond of sports and whatnot. She is confirmed to be a lesbian, and it is hinted that she has feelings for Shirley. In season 2, she and Shirley become an official couple.
 * Jayden MaCoy (voiced by Phil LaMarr) - a chill African-American teenager who is one of Shirley's best friends.
 * Marvin Atkins (also voiced by Billy West) - a comedic teenager who is also one of Shirley's best friends.
 * Cindy Brady (voiced by Catherine Taber) - an easily bored teenage girl who is one of Shirley's best friends.
 * Suzy Saunders (voiced by Grey DeLisle) - a cynical and quiet goth girl who usually tends to be snarky towards other teenagers, including Shirley, yet she does have sympathy.
 * Jonathan (voiced by TBD) - a friendly hammerhead shark who is well known friends with Octo.
 * Anna and Anthony (voiced by TBD and TBD, respectively) - a kind goldfish and a goofy shark who are best friends, living together as roommates and helped Octo escape the aquarium to return to Shirley. It is implied they have a crush on each other.
 * Axy (voiced by Frank Welker) - an axolotl who is in the Hitsonville Aquarium, and one of the sea creatures that helped Octo escape the aquarium.
 * Lobso (voiced by Doug Lawrence) - a cowardly lobster who is in league with the Aquarium head.
 * Tangy (voiced by Jennifer Hale) - a flirtatious blue tang.

Antagonists

 * Mary Barron (voiced by Kath Soucie) - a spoiled teenage girl who wants to be the most popular girl in school as she often pokes fun at Shirley and her friends, as well as leading a group of girls who are like Mary.
 * Masie Rangles (also voiced by Jennifer Hale) - one of Mary's best friends who is dumb.
 * TBD
 * Squick (voiced by Jim Cummings) - a rude squid who has been Octo's rival since they were younger.

Episodes
See List of episodes.

Comic book adaption
See Octopus is My Best Friend Forever.

Transcripts
See /Transcripts.

Tropes
See /Tropes.