Spider-Girl: Irresponsible

Spider-Girl: Irresponsible is an American action-adventure comic book series published by Marvel Comics which is a spin-off of the series Spider-Man: Irresponsible, taking place in a possible future where Peter has a child with Mary Jane Watson.

Main

 * May "May-Day" Parker/Spider-Girl - the daughter of Mary Jane Watson and Peter Parker who takes after her father quite a bit, having both his powers and his delinquent-like personality.

Supporting

 * Peter Parker - formerly known as Spider-Man, Peter retired quite a few years prior due to the loss of his leg during his final battle with the Green Goblin.
 * Mary Jane Watson - Peter's girlfriend who takes care of him after the loss of his leg and who is extremely social, outgoing and rather enjoys meeting new people.
 * Norman Harold "Normie" Osborn - Harry's rather innocent son who is May-Day's best friend.
 * Davida Kirby - May's friend who is one of the "cool kids" at school and who she goes to for help and advice on complicated situations.
 * Jimmy Yamma - TBD
 * Courtney Duran - TBD
 * Jack Jonah Jameson/The Buzz - J. Jonah Jameson's grandson who, ironically, loves superheroes and eventually becomes one himself.
 * Gwendolyne "Gwen" Stacy - TBD
 * Harold "Harry" Osborn - TBD

Antagonists

 * Roderick Kingsley/Hobgoblin - a terrorist who believes superhumans are inherently superior and thus must be torn down to human levels for the sake of making everyone equal.
 * Fabian LaMuerto/Black Tarantula - a man who has committed a large variety of crimes and is also a criminal for hire and who is obsessed with May.
 * Elan DeJunae/Fury the Goblin Queen - a scientist who is obsessed with Norman Osborn and who wants Normie to become just like his grandfather.
 * Carolyn Trainer/Doctor Octopus - a young scientist who, inspired by the old Doctor Octopus, becoming a criminal and who is extremely intelligent.
 * Green Goblin - While Norman Osborn is deceased, he is able to return through Peter, transferring part of his mind into him, which sometimes causes Peter to believe he is Osborn.
 * Seth - the Egyptian god of death who resembles a large snake with a humanoid body and who leads an army of cultists known as the Soldiers of the Serpent.
 * Mr. Nobody - a more street-level criminal who is the current head of crime in New York City. He is megalomaniacal and values power over everything else.
 * Raniere "Blackie" Drago/Vulture - one of Peter's old enemies who is now older and going under the alias of Adrian Toomes, still being the Vulture.
 * Fritz von Meyer/Swarm - a Neo-Nazi scientist who mutates himself into a sentient swarm of bees.
 * Blank - a man who doesn't have a face and who has a calm attitude most of the time but is prone to fits of rage. He mostly works as a hitman for other criminals.
 * Jacob Nash/Shade - a criminal obsessed with unlocking the secrets of the astral plane, now being one with it and needing a human to take his place so he can stay on Earth.
 * Mandy Thomas/Looker - a girl who has a large eye for a head and who has the ability to paralyze people by looking at them. Despite her obvious deformity, she is extremely egotistical.
 * Samantha Slice - an eleven-year-old super genius who is a criminal mastermind that constantly tries to get their way by any means necessary.
 * Cut - Slice's mute robot who has extremely sharp arms and legs that are able to cut through the strongest of metals.