Star vs. The Powerpuff Girls: Clash of Two Worlds

 is an open-world science-fantasy-western-adventure-comedy video game based on Disney XD's television series Star vs. the Forces of Evil and Cartoon Network's television series The Powerpuff Girls. It is developed by Avalanche Software and released by Warner Bros. Interactive Entertainment (under license of The Walt Disney Company), being released for PC, Mac, PlayStation 4, Xbox One and Nintendo Switch on TBD.

Main

 * Star Butterfly (voiced by Eden Sher) - TBD
 * Blossom (voiced by Cathy Cavadini) - TBD
 * Bubbles (voiced by Tara Strong) - TBD
 * Buttercup (voiced by E.G. Daily) - TBD
 * Marco Diaz (voiced by Adam McArthur) - TBD

Supporting

 * Pony Head (voiced by Jenny Slate) - TBD
 * Professor Utonium (voiced by Tom Kane) - TBD
 * King and Queen Butterfly (voiced by Alan Tudyk and Grey Griffin, respectively) - TBD
 * Mr. and Mrs. Diaz (voiced by Art Butler and, respectively) - TBD
 * The Mayor of Townsville (also voiced by Tom Kenny) - TBD
 * Ms. Sara Bellum (voiced by Jennifer Martin) - TBD
 * Ms. Keane (voiced by Jennifer Hale) - TBD
 * Jackie Lynn-Thomas (also voiced by Grey Griffin) - TBD
 * Tom Lucitor (voiced by Rider Strong) - TBD
 * Sensei Brentley (voiced by ) - TBD
 * The Narrator (also voiced by Tom Kenny) - TBD

Antagonists

 * Chaos (voiced by Kristen Bell) - TBD
 * Ludo (also voiced by Alan Tudyk) - TBD
 * Mojo Jojo (voiced by Roger L. Jackson) - TBD
 * Toffee (voiced by ) - TBD
 * Him (also voiced by Tom Kane) - TBD
 * Eclipsa Butterfly (voiced by ) - TBD
 * Princess Morbucks (also voiced by Jennifer Hale) - TBD
 * Miss Heinous (voiced by ) - TBD
 * The Gangreen Gang, consisting of:
 * Ace Copular (voiced by Jeff Bennett) - TBD
 * Sanford "Snake" Ingleberry (also voiced by Tom Kenny) - TBD
 * Arturo "Lil' Arturo" de la Guerra (also voiced by Tom Kenny) - TBD
 * Grubber (also voiced by Jeff Bennett) - TBD
 * William "Big Billy" Williams (also voiced by Jeff Bennett) - TBD
 * Sedusa (also voiced by Jennifer Hale) - TBD