The Ups & Downs of Dating A Supervillain

The Ups & Downs of Dating A Supervillain is an American adult animated superhero sitcom developed and created by Seth Carter for Adult Swim, premeiring on the network on June 15, 2021. The series follows the lives of the titular supervillain Tina McCree, AKA Doctor Toxin, and her boyfriend Max Fischer (voiced by Aubrey Plaza and Rainn Wilson, respectively) as they attempt to form a stable relationship despite Tina's bizarre and amoral career path.

Synopsis
The show revolves around protagonists Tina McCree and her boyfriend Max Fischer. Tina is a professional supervillain who works under the alias Doctor Toxin and has dreams of world conquest while Max, in comparison, is unemployed but is the primary caretaker of the house. The series follows them as they attempt to have a normal relationship despite Tina's career, which often comes in between the two and causes problems that they must deal with.

Main

 * Aubrey Plaza as Tina McCree/Doctor Toxin, one of the series' two protagonists and the main focus of it. She is a professional supervillain who is out to coquer the world and destroy her enemies. She is based on old Silver Age depictions of supervillains, such as that of DC Comics' Lex Luthor. She is highly eccentric, charismatic, and an expert in all fields of scientific study, but also suffers from an inflated ego and a tendancy towards anger.
 * Nicholas Hoult as Max Fischer, Tina's boyfriend and the second of the series' protagonists. Throughout most of the series he is unemployed but is the caretaker of the house, being left to clean it up and cook meals for himself and Tina. He appears to have an obsession with social media, as he can often be seen on his phone, and a recurring gag throughout the series is how desensitized he is to the abnormal anticts Tina gets up to.
 * Andy Samberg as Mitch the Henchman, the head of Tina's henchmen and her secretary that handles her financials. He is weak-willed, meek, and is often berated by Tina, though she enjoys his company and often drags him along on her adventures. His job working for Tina leaves him constantly stressed out but he refuses to leave due to being in love with her, though he is unwilling to admit it.
 * Jessica Williams as Patty Dane/Crimson Lady, an old friend of Tina's and the world's most wanted woman. She is the feared leader of the terrorist organization the Crimson Cabal and presents herself as a terrifying femme fetale, though in actuality she is a lonely single woman who is distraught about her age and copes with sarcasm and quips. Tina and her often ask each other for advice, though Tina seems to consider her the wiser of the two.

Recurring

 * Walton Goggins as Todd Filton/Major Venus, Tina's archnemesis and the most popular superhero in the world. He has several superhuman abilities and is a parody of Silver Age depictions of superheroes such as that of Superman. He acts charismatic and hopeful but it is eventually revealed he feels a deep unsatisfaction in his career.
 * Lauren Cohan as Nina McCree/Mindfuck, Tina's sister who is an extremely famous supervillain with psychic powers. She acts like a stereotypical famous celebrity, throwing parties and seeming to not be very bright. Her attitude combined with a complicated childhood has put a wedge between the sisters' relationship.