The Legend of Spider-Man

 is an American action-adventure-thriller superhero comic book series, being published by Marvel Comics since December 28th, 2018.

Synopsis
The series retells once more the Spider-Man mythos by following the life of Peter Parker since he was bitten by a radioactive spider, now being a web-slinging vigilante ready to protect New York City.

Main

 * Peter Parker/Spider-Man - an intelligent but shy student at Midtown High who developed spider-like abilities after being bitten by a radioactive spider and uses them to protect New York City from crime.

Supporting

 * Aunt May Parker (née Reilly) - Peter's caring aunt who takes care of him after his parents and his Uncle Ben's death and often worries about his life, being unaware of his dual identity.
 * Uncle Benjamin "Ben" Parker - Peter's protective uncle who ends up killed by a serial killer known as Dennis Caradine at the first issue, giving him the motto who influenced the rest of his life: with great power comes great responsibility.
 * Harold "Harry" Osborn - Peter's wealthy best friend who struggles with his tense relationship with his father due to his mother's death when he was younger and tries to make him proud while he's unaware that he is secretly the Green Goblin and that Peter is Spider-Man.
 * Mary Jane "MJ" Watson - a beautiful and rather intelligent classmate and childhood friend to Peter who develops a crush on him and often nicknames him "Tiger", being one of the few people who are aware that he's Spider-Man after discovering that fact by accident.
 * Gwendolyne "Gwen" Stacy - Capt. Stacy's intelligent and athletic daughter who is MJ's closest friend and also falls in love with Peter, being sometimes worried about his safety, as well as being unaware of his double life as she tries her best to become a detective like her father.
 * Teresa Parker - Peter's goofy long lost younger sister who was raised by Nick Fury after their parents' death and first crosses with him after an incident involving Peter teaming up with S.H.I.E.L.D., looking at him as a role model in order to be a great heroine in the future.
 * Miles Morales/Kid Arachnid - an African American-Puerto Rican classmate to Peter who, like him, gets bitten by a radioactive spider, eventually developing powers to him, but also developing exclusive powers with Spider-Man assuming his mentorship to become a hero on his own like him.
 * Eugene "Flash" Thompson - the captain of the Midtown High football team who acts as the school's bully, mainly to Peter and sometimes Harry, and ironically idolizes Spider-Man, being unaware that he is actually Peter, eventually growing some respect for him.
 * Elizabeth "Liz" Allan - one of MJ and Gwen's friends who is a cheerleader and used to date Flash until they broke up for argumental reasons as she is nicer than others.
 * Sally Avril - one of MJ and Gwen's classmates who is a skilled gymnast and somewhat intelligent but also self-absorbed and arrogant, seeming to dislike Peter due to his status as a nerd, despite being one as well.
 * Cindy Moon/Silk - a Korean American teenage girl who is bitten by the same spider as Peter and has the same abilities as him. Peter is unaware of her existence for some time due to her suddenly going missing after being bit.
 * Anya Corazon/Spider-Girl - a Hispanic American teenage girl who is known for her intelligence and acquired her powers through a ritual after almost being killed, using them to become a hero inspired by Peter.
 * Felicia Hardy/Black Cat - a jewel thief who also attends Midtown High and is known for giving bad luck to her adversaries, often teasing and flirting with Peter just to make him flustered.
 * Carlie Cooper - a geeky student at Midtown High who is Peter's first love interest.
 * J. Jonah Jameson - the arrogant and egocentric editor-in-chief of the Daily Bugle who has a grudge against Spider-Man, fearing that he might be a bad example for society, despite his good intentions. However, he's still pure-hearted as he is actually afraid of the city being haunted by even worse menaces.
 * Elizabeth "Betty" Brant - Jameson's calm secretary who wants to succeed in life by following a career in journalism, often making fun of her boss for his beliefs. Jameson is unable to fire her due to no one else wanting the job.
 * Joseph "Robbie" Robbertson - a high-ranking editor at the Daily Bugle who is a close friend to Jameson and wishes that he wasn't so harsh and angry about Spider-Man since he believes he isn't menacing as he claims.
 * Edward "Ned" Leeds - an ace reporter who is engaged to Betty and has a strong sense of justice. He and Spider-Man are good friends due to Spider-Man defending him when he was accused of being Hobgoblin.
 * Capt. George Stacy - the captain of the New York Police Department and Gwen's father who, unlike Jameson, considers Spider-Man as a true hero and essential help to fight crime.
 * Officer Jefferson Davis - Miles' father who cares about him but often embarrasses him in front of his friends. He is attempting to raise Miles right in spite of the fact Miles keeps getting involved with Jefferson's criminal brother.
 * Det. Jean DeWolff - TBD
 * Det. Yuriko "Yuri" Watanabe - a Japanese American detective who becomes intrigued about Spider-Man and sometimes helps him in his quest to protect New York.
 * Rio Morales - Miles' mother who works as an EMT and is TBD.
 * Lee Stanley - a news reporter for WABC-TV who is known for his rather comedic jokes and often reports on Spider-Man or the villains' acts. He's is modeled after Spider-Man ' s co-creator Stan Lee who died shortly before the comic's release.
 * Dr. Martha Connors - Curt's wife who is a scientist as well and tries to find a cure for his mutation as she occasionally provides Peter with aid, such as equipment to help him during big fights.
 * John Jameson/Man-Wolf - Jameson's son who is a NASA astronaut and who is loved by his father very much. He has a strong sense of justice but later becomes the host of an alien artifact that turns him into a werewolf-like creature.
 * Silver Sablinova/Silver Sable - a Symkarian mercenary for hire who starts out as antagonist for a while until she eventually understood that Spider-Man is not a menace like she originally thought of and becomes a frenemy of him.

Antagonists

 * Dr. Norman Osborn/Green Goblin - the head of OsCorp who is Harry's father and who is dealing with an unstable mental disorder after being exposed to an experimental serum, eventually taking the name Green Goblin and almost immediately becoming de facto Peter's arch-nemesis.
 * The Sinister Six, consisting of:
 * Dr. Otto Octavius/Doctor Octopus - an incredibly intelligent but myopic mad scientist who is obsessed to prove that he is the greatest mind around by attaching four robotic tentacles into himself to cause mass chaos.
 * Flint Marko/Sandman - a tragic former mob enforcer who, after an unfortunate accident, is transformed into living sand. In spite of his former role as a mob enforcer, he refuses to endanger or kill anyone unless it is in self-defense.
 * Maxwell "Max" Dillon/Electro - a former electrician whose body is turned into a living electrical generator after an accident. Instead of doing anything useful with his abilities, he becomes a criminal for hire and jewel thief.
 * Adrian Toomes/Vulture - a crooked investor whose company was bought out by Oscorp, placing him out of work. Blaming Norman, he dons a suit that allows him to levitate in the air and has built-in metal claws.
 * Sergei Kravinoff/Kraven the Hunter - a Russian hunter who is known for hunting with his bare hands and aims for the death of the biggest prey in the world. Recently, he's become obsessed with hunting Spider-Man.
 * Quentin Beck/Mysterio - a former OsCorp employee who decides to turn against his employer after being deemed a danger to himself and others, using his suit to become a faux hero and eventual criminal.
 * Roderick Kingsley/Hobgoblin - a former Oscorp designer whose most famous designs were borderline stolen by Norman. After Norman's identity is exposed, he steals something of his and attempts to become a better Goblin than him.
 * Dr. Curtis "Curt" Connors/Lizard - a genetic biologist and a friend of Peter who was mutated into a lizard-like creature, ending up becoming dangerous and unstable as well as losing all traces of his original personality.
 * Edward "Eddie" Brock/Venom - an investigative journalist who bonds with an alien symbiote, becoming a feral and extremely dangerous creature who wants Peter dead for causing his firing from the Daily Bugle after it was revealed he was falsifying some facts to degenerate Spider-Man's reputation.
 * Anne Weying/She-Venom - a district attorney and Eddie's fiancée who gains a bond with another symbiote, leading to her become a female counterpart to Venom, though in her case the symbiote is in the driver's seat.
 * Cletus Kasady/Carnage - a serial killer so dangerous he was sent to a prison meant for supervillains. After his cellmate, Eddie Brock, regains his symbiote, Kasady bonds with its offspring and swears to wreak carnage on the land.
 * Wilson Fisk/Kingpin - the most powerful mob boss in New York City who develops a grudge against Peter for taking his drug trade down and who swears to ruin his life in any way possible.
 * Elektra Natchios - a Greek assassin hired by Kingpin to kill anyone who messes with his gang or tries to take down his criminal empire by using her twin pair of sais.
 * Dennis Caradine - a shooter under Fisk's hire who is the man responsible for Uncle Ben's death. He later dies at Fisk's hands due to him being too easily traced back to Fisk.
 * Jonas Harrow - a scientist who claims to put the "super" in "supervillain", working with Fisk to create superpowered criminals to defeat Spider-Man.
 * Lonnie Lincoln/Tombstone - an albino mob enforcer who is known for having incredibly strong skin, which is so thick it hurts to hit him. Tombstone is feared by all who know of him and is a former friend of Robbie's.
 * Hammerhead - a mob enforcer whose head had silicone injected into it by Jonas Harrow. He speaks and acts like a stereotypical 1950s gangster and, thanks to the metal in his head, is able to bash through solid bricks.
 * Silvio Manfredi/Silvermane - a mob boss so old no one is sure of his exact age. He's managed to keep himself alive for all these years thanks to constantly replacing, or "upgrading", his body with cybernetic parts.
 * Martin Li/Mr. Negative - the head of the F.E.A.S.T. programs who leads a group of terrorists known as the Inner Demons, being out to topple all other crime lords in New York and leave himself as the head.
 * MacDonald "Mac" Gargan/Scorpion - a former street gang leader who was upgraded to a supervillain after an encounter with Norman Osborn that grants him many different abilities at the cost of his mind.
 * Alexander "Alex" O'Hirn/Rhino - a deranged military officer who goes on a rampage and is sentenced to death. However, he is found by Osborn and, in exchange for his life, becomes a human experiment and has indestructible armor placed on him.
 * The Enforcers, consisting of:
 * Jackson Brice/Montana - the leader of the Enforcers who TBD.
 * Daniel Brito/Fancy Dan - TBD
 * Raymond Bloch/Ox - TBD
 * Miles Warren/Jackal - TBD
 * Herman Schultz/Shocker - a small time criminal who stole shock gauntlets becoming a mad supercriminal.
 * Lily Hollister/Menace - TBD
 * Calypso - an African shaman who gave Kravenoff his powers to TBD.
 * Anthony "Tony" Masters/Taskmaster - TBD
 * The Menagerie, consisting of:
 * Dr. Lorina Dodson/White Rabbit - TBD
 * Hippo - TBD
 * Panda-Mania - TBD
 * Vincent Patilio/Leapfrog - TBD
 * Screwball - TBD
 * Jackson Weele/Big Wheel - a businessman who TBD.
 * Ulysses X. Lugman/The Slug - a fat mob boss who has more TBD.
 * Dr. Mendel Stromm - a former OsCorp employee who gains the power of TBD.
 * Dr. Jackson Avrad/Will o' the Wisp - TBD
 * Massacre - a former soldier who becomes mentally insane TBD.

Differences

 * Aunt May and Uncle Ben are slightly younger, being in their mid-50s.
 * Peter, Harry, MJ, Gwen, and, to a minor extent, Flash, Liz, and Sally know each other since they were children.
 * Teresa is introduced to Peter when they are teenagers rather than when they were both adults.
 * Felicia is de-aged into a teenager as she keeps her crush on him.
 * The Green Goblin failed to kill Gwen as Peter achieves to save her just in time by using his webs to create a strong net to avoid her fall, leading to her rescue afterward.

Extended universe
See Earth-357427.

Following the success of the comic, Marvel announced that would create an extended universe set on Earth-357427 with its first announced titles being Captain America: The First Super Soldier, Iron Man: Master of Machines, Behold the Incredible Hulk, Flight of the Avengers and The Fantastic Four.

Trivia

 * The comic is not canon to the current continuity, being set in its own continuity.
 * The continuity where the comic is set is named Earth-357427.
 * The creators of the comic opted to not kill Gwen in this continuity as they considered that the event was getting old and repetitive in most Spider-Man media and due to her increase in popularity in recent years.