Clifford: The Big Red Mystery

Clifford: the Big Red Mystery is a 2026 American 3D computer-animated mystery comedy adventure film loosley based on Norman Bridwell's book series Clifford the Big Red Dog and Arthur Conan Doyle's Sherlock Holmes series. The film is a stand-alone sequel to 2004's Clifford's Really Big Movie and stars Jason Ritter, Kenan Thompson, Jenny Slate, Michael Caine, Jeff Foxworthy, Leslie Mann, Megan Fox, Hugh Jackman, Kenneth Branagh, Emily Mortimer, Javier Bardem, Ralph Fiennes, Patrick Warburton, Kevin Hart, Tom Everett Scott, Seth Rogen, and Christina Applegate. In the film, Clifford the Big Red Dog and his friends team up with the fictional detective Sherlock Holmes and his friend Watson in order to figure out who is the mastermind behind the murder of Captain Armando Edwards, who is believed to have been killed by Clifford's owners, the Howards. The film is produced by Warner Animation Group and was released on September 4, 2026, by Warner Bros. Pictures. It received generally positive reviews from critics and grossed over $600 million on an $80 million budget.

Synopsis
When a murder breaks out around all of Birdwell Island, it's up to Clifford the Big Red Dog and his friends to figure out who really did it... with the help of Sherlock and Watson, of course.

Voice cast

 * Jason Ritter as Clifford the Big Red Dog, a large red Labrador Retriever/Viszula crossover and the main protagonist.
 * Kenan Thompson as T-Bone, a yellow and orange bulldog with a large appetite.
 * Jenny Slate as Cleo, a sarcastic purple poodle, always into fashion.
 * Michael Caine as Mac, a snobby British blue greyhound.
 * Jeff Foxworthy as K.C., a lemon beagle with a laidback personality.
 * Patrick Warburton as Basin, a vicious Jack Russell Terrier.


 * Leslie Mann as Emily Elizabeth Howard, a 17-year old girl and Clifford's kind human owner.
 * Dakota Fanning as a younger Emily Elizabeth.
 * Megan Fox as Jetta Handover, Emily's friend and close confidant.
 * Jenna Ortega as a younger Jetta.
 * Hugh Jackman as Sherlock Holmes, a fictional British detective who teams up with Clifford and his friends to find out who murdered Captain Armando Edwards.
 * Kenneth Branagh as Dr. John Watson, Sherlock's assistant and best friend.
 * Emily Mortimer as Irene Adler, Sherlock's girlfriend who works as a waitress at a bar.
 * Javier Bardem as John Robertson, a sinister murder who has killed at least 203 people across Birdwell Island, including Armando Edwards.
 * Ralph Fiennes as Professor James Moriarty, Sherlock's arch-enemy who works alongside Robertson, writing down his partner's every word.
 * Kevin Hart as Charlie, Emily Elizabeth's best friend.
 * Tom Everett Scott as Vaz, another friend of Emily Elizabeth's.
 * Seth Rogen and Christina Applegate as Mark and Caroline Howard, Emily Elizabeth's parents, respectively.
 * Jonah Hill as Sheriff Lewis, the sheriff of Birdwell Island.
 * Taraji P. Henson as Mrs. Diller, a fashion designer from upstate New York who now works as a clothing designer in Birdwell Island.
 * Russell Crowe and Shirley MacLain as Horace and Violet Bleakman, the Howards's next-door neighbors, respectively.