Earth-646 Marvel Universe

The Earth-646 Marvel Universe is a more down-to-Earth, mature version of the Super Hero Squad Universe that is a mix of the Marvel Cinematic Universe, the Avengers: Earth's Mightiest Heroes Universe, X-Men: Evolution, the Ultimate Marvel Universe, the Marvel Anime Universe, and plenty more.

Asgardian Times
Years after the Big Bang, there was a war between the Asgardians and the Frost Giants from Jotunheim. However, this feud ended when the ruler of Asgard, Odin, decided to take a newborn son (who would then be named Loki Laufeyson) as a peace offering between the two realms. As time passed, Odin and his spouse Frigga brought up their firstborn child, Thor Odinson, who would be good friends and companions with his adopted brother Loki. The two brothers would later on be trained by their parents to either learn how to use magic (Frigga to Loki) or learn how to fight like a true warrior (Odin to Thor). After reaching adulthood, Thor would then receive the godlike hammer Mjolnir, but he and his brother Loki would go their seperate ways and head to different paths.

World War II
In New York City, December 1941, Steven Grant Rogers would get constantly rejected in joining the United States, due to his fraility and health issues. Though, Rogers' determination caught the attention of Dr. Abrham Erskine, who would then enlist young Rogers into Project: Rebirth and transform him into the world's first Super Soldier: Captain America. The Captain became a living icon to those who wish to enlist in order to serve their country, and would lead the Howling Commandos, along with his fellow companion James Buchanan Barnes, against the tyrannical Red Skull and his massive army of HYDRA soldiers. However, after a hard fought battle, Captain America's whereabouts were left unknown.

Present Time
As November 16, 1980 hits, Obadiah Stane, and later on in May 29, 1991, Anthony Antonio Stark took over as CEO of Stark Inudstries after the deaths of both Howard and Maria Stark. After Stark Industries obtained its booming popularity in 2005, other companies such as Roxxon, Octavius Labs, Fisk Industries, Hammer Industries, and Oscorp would be at arms with the company. However, this would also the same year when certain events occured such as Stark being captured by a terrorist organization known as the Ten Rings, Dr. Bruce Banner testing a "replication" of the Super-Soldier Serum back in 1941, and Thor Odinson being banished out of Asgard into Midgard/Earth. 2006 would mark the "births" and sightings of these "Modern-Day Heroes" including the Invincible Iron Man (Stark), the Mighty Thor, and the Incredible Hulk (Banner). Two years later, the top secret government organization known as S.H.I.E.L.D would keep tabs on these "Modern-Day Heroes", and when the time, gather them up while dethawing the Super Soldier of World War II Captain America out of his cryostasis, encouraging them to "activate" the Avengers Initiative.

The Battle of New York
2008 brought in more of these "Modern-Day Heroes" including the cosmic-powered heroine Captain Marvel (Carol Danvers), the Wakandan king Black Panther (T'Challa), and the Pym Particle wielding duo Ant-Man and Wasp (Hank Pym and Janet Vyn Dyne). S.H.I.E.L.D personnel Nicholas Fury, Phil Coulson, Natasha Romanoff, and Clint Barton would bring all them in with the inclusion of Captain America, Iron Man, Dr. Banner, and Thor to discuss the fate of the world as they know it. This same year would also mark the day when Loki of Asgard and Dr. Doom of Latveria would wage war on who would be able to receive the limitless power of the artifact known as the Infinity Sword. This war between Loki's Chitauri army and Dr. Doom's Latverian forces had New York caught in the crossfire and brought on the attention of S.H.I.E.L.D's own task force, later to be Earth's Mightiest Heroes: Avengers. Although the Avengers managed to prevail in this global threat, it wasn't without any certain casualities such as the deaths of 400 innocent bystanders (some of them were either in the NYPD) and the death of Hank Pym. This may have the Avengers' first downfall, but it was the courage of their fallen friend that kept them going forward into the future.

Aftermath
Ten months after the "Incident", several others including Hell's Kitchen's Daredevil (Matt Murdock) and the "agent of Punishment" Punisher (Frank Castle) would go out day and night to protect New York from all sorts of crime and injustice while other teams like the Avengers, the Fantastic Four, the six youngest members of Professor Charles Xavier's X-Men, and S.H.I.E.L.D's New Warriors would take on other global threats. However, Luke Cage (formerly known as Power Man and Carl Lucas), Iron Fist (Danny Rand), Wolverine (James "Logan" Howlett) and Spider-Man (Peter Parker) would choose to leave their teams, due to certain "issues" and become more street-level like Daredevil and the Punisher. In 2010, Spider-Man would meet an entity known as Madame Webb and discuss about an artifiact known as the Tablet of Order and Chaos in order to save the realities of other Spider-Men. Six years later after this event, Spider-Man would lead of team of these alternate web-slingers dubbed the Spiders, but would also start to get himself in more trouble than he was already in to begin with and retire from doing any heroics to focus on his family life. However, the former Spider-Man Peter Parker would later "pass the torch" over to his protégé and adopted brother Kendrick Urgena, who now calls himself the All-New Spider-Man.

Series

 * The All-New Spider-Man (first actual appearance)
 * The Marvel Universe (2015 series)

The Avengers

 * Steven Grant Rogers (voiced by Travis Willingham)
 * as Captain America
 * in his WWII uniform
 * in his "Captain" uniform
 * in his Avengers uniform
 * in his Stealth uniform
 * in his second Avengers uniform
 * Anthony Antonio Stark (voiced by Chris Pine)
 * as Iron Man
 * in his Mark I Armor
 * in his Mark II Armor
 * in his Mark III Armor
 * in his Prodigal Son Armor
 * in his Bleeding Edge Armor
 * Robert Bruce Banner (voiced by Yuri Lowenthal)
 * as the Hulk (voiced by Fred Tatasciore)
 * Thor Odinson (voiced by Jim Cummings)
 * as a child (voiced by Dakota Goyo)
 * in his Asgardian garb
 * in his Avengers uniform
 * Carol Danvers (voiced by Laura Bailey)
 * as Captain Marvel
 * T'Challa (voiced by Keith David)
 * as Black Panther
 * in his Wakandan garb
 * in his Avengers uniform
 * Henry "Hank" Pym *deceased/replaced* (voiced by Parry Shen)
 * as Ant-Man
 * in his Pym Particles uniform
 * in his Avengers uniform
 * Janet Van Dyne (voiced by Ashly Burch)
 * as Wasp
 * in her Pym Particles uniform
 * in her Avengers uniform
 * Scott Lang *replaces Hank Pym* (voiced by Paul Rudd)
 * as Ant-Man

Neutrality

 * Wade Winston Wilson/Deadpool (voiced by Nolan North)
 * Yellow box (voiced by Will Friedle)
 * White box (voiced by Troy Baker)

Dr. Doom's Lethal Legion

 * Victor Von Doom/Dr. Doom (voiced by Clancy Brown)
 * Valentin Shotolov/Crimson Dynamo (voiced by Robin Atkin Downes)
 * Baron Helmut Zemo (voiced by Maurice LaMarche)
 * Ezekiel Stane/Iron Menace (voiced by Mark Wahlberg)
 * Emil Blonsky/Abomination (voiced by John DiMaggio)

Loki's Lethal Legion

 * Loki Laufeyson (voiced by Jonathan Rhys Meyers)
 * Amora/Enchantress (voiced by Lena Headey)
 * Skurge the Executioner (voiced by Kane from WWE)
 * Malekith the Accursed (voiced by Richard Ian Cox)
 * Kurse (voiced by Kevin Michael Richardson)