Power Girl!

 is a superhero animated TV series, based on the DC Comics character of the same name, airing on HBO Max.

Premise
A young teenager named Karen Starr is given special superhero abilities after finding out she is the biological cousin of Superman, and becomes a new hero of National City named Power Girl.

Main

 * Kara Zor-L/Karen Starr/Power Girl (voiced by Aimee Carrero) - a teenager who finds out she is the biological cousin of Superman after learning she shares his Kryptonian powers, and uses them to become a superheroine.

Supporting

 * Krypto - a small dog that Karen decides to adopt, often liking to take care of him.
 * Kristen Wells (voiced by Colleen O'Shaughnessey) - a nerdy teenager who is Karen's best friend as she absolutely is fascinated by aliens, being fascinated by Power Girl.
 * Prof. Emil Hamilton (voiced by TBD) - a professor at Karen's school who in his own time studies aliens as he learns Karen is Power Girl and helps mentor her.
 * Ursa (voiced by Ashley Tisdale) - a Czarnian freedom fighter and explorer who survived Amalak's killing of their own kind. Along with the same powers and abilities of Lobo (such as superhuman strength and speed on par with Power Girl, hand-to-hand combat skills, regeneration, immortality and invulnerability), Ursa can also replicate herself, and wields the Lightning Siren, a guitar which she can also use as a hammer-like weapon, and flies across the galaxy in the Star Tiger, a space-travelling motorcycle resembling of a winged white tiger. Described as the opposite of Lobo by appearance and personality, Ursa is also more heroic and friendly towards other people (including superheroes), including Power Girl.
 * Jerry Schuman (voiced by TBD) - the owner of National City's branch of the Daily Planet who allows Karen to intern under him, being interested in Power Girl.
 * Georgia Schuman (voiced by TBD) - Jerry's optimistic daughter who also works for the Daily Planet as she is a mega fan of superheroes, loving all of them.
 * Courtney Whitman (voiced by TBD) - a young fan of superheroes who is the step daughter of the hero STRIPE as she befriends and helps Power Girl out when she can.
 * Kal-El/Clark Kent/Superman (voiced by George Newbern) - the main protector of Metropolis and Karen's cousin who occasionally visits her in National City, wanting to help her out at times.
 * Lobo (voiced by TBD) - a Czarnian bounty hunter who both clashes against and occasionally works with Superman as he gets involved with Power Girl while searching for the truth behind his planet’s destruction.
 * Alan Scott/Green Lantern (voiced by TBD) - one of the last surviving members of the Justice Society as he has retired heroics, briefly returning to work with Power Girl to stop the new Icicle.

Antagonists

 * Amalak (voiced by TBD) - a space pirate who despises all Kryptonians with a passion as he arrives to National City, wanting to capture and destroy the last Kryptonians. It is revealed he also despised Czarnians and slaughtered all of them besides two.
 * Granny Goodness (voiced by TBD) - a traitor to Apokalips who has grown tired of Darkseid's rule, deciding to work with Amalak to bring a new rule to the galaxy, together.
 * Mr. Z (voiced by TBD) - a calm yet mysterious immortal crime lord who has his hands all over National City as he becomes fascinated by Power Girl.
 * Alex Trent/Bloodsport (voiced by TBD) - Mr. Z's sadistic enforcer who wants to fight someone who can be a challenge to him, wielding high tech weaponry.
 * Henry Miller/Atom Man (voiced by TBD) - a pathetic thug who is the first threat that Power Girl has faced as he works for Mr. Z and is granted a suit powered by nuclear energy.
 * La Enchantadora (voiced by TBD) - a mysterious conwoman who can create enhanced illusions as she operates out of National City, soon growing rather fascinated by Power Girl.
 * Fiona Frankenstein/Riot (voiced by TBD) - Emil's insane former lab assistant who mutates into a terrifying creature who can multiply herself, wanting destruction.
 * Paul Brooker/Major Disaster (voiced by TBD) - a former Cadmus scientist who went mad, wearing a suit that allows him to make disasters, wanting to create an age of chaos.
 * Queen Clea (voiced by TBD) - the vile queen of a sea fairing tribe who wants power and destruction, believing that she should rule all over the surface world.
 * King Shark (voiced by TBD) - an anti-heroic yet brutal demigod who is out to serve his own interests, both working with and against Power Girl.
 * Cameron Mahkent/Icicle (voiced by TBD) - the son of the deceased Icicle who wants revenge on all heroes for the death of his father, wanting to bring forth a blizzard that will destroy all heroes.