The Legend of Spider-Man

 is an American action-adventure-thriller superhero comic book series, being published by Marvel Comics since December 28th, 2018.

Synopsis
The series retells once more the Spider-Man mythos by following the life of Peter Parker since he was bitten by a radioactive spider, now being a web-slinging vigilante ready to protect New York City.

Main

 * Peter Parker/Spider-Man - an intelligent but shy student at Midtown High who developed spider-like abilities after being bitten by a radioactive spider and uses them to protect New York City from crime.

Supporting

 * Aunt May Parker - Peter's caring aunt who takes care of him after his parents and his Uncle Ben's death and often worries about his life, being unaware of his dual identity.
 * Uncle Benjamin "Ben" Parker - Peter's protective uncle who ends up killed by a burglar at the first issue, giving him the motto who influenced the rest of his life: with great power comes great responsibility.
 * Harold "Harry" Osborn - Peter's wealthy best friend who struggles with his tense relationship with his father and tries to make him proud while unaware that he is the Green Goblin and that Peter is Spider-Man.
 * Mary Jane "MJ" Watson - one of Peter's beautiful classmates and a childhood friend of him who develops a crush on him and often nicknames him "Tiger", being one of the few people who is aware that he's Spider-Man after discovering that fact by accident.
 * Gwendolyne "Gwen" Stacy - Capt. George Stacy's intelligent and athletic daughter who is MJ's closest friend and also falls in love with Peter, being sometimes worried about his safety, as well as TBD.
 * Lana Osborn/Vibranium Goblin - Harry's geeky cousin who moves to New York City and immediately becomes a potential love interest to Peter in addition to becoming a vigilante in order to protect the city from further menaces, especially the ones schemed and led by his uncle Green Goblin.
 * Miles Morales/Kid Arachnid - an African American-Puerto Rican classmate to Peter who, like him, gets bitten by a radioactive spider, eventually developing powers to him, but also developing exclusive powers with Spider-Man assuming his mentorship to handle TBD.
 * Eugene "Flash" Thompson - the captain of the Midtown High football team who acts as the school's bully, mainly to Peter and sometimes Harry, and ironically idiolizes Spider-Man, being unaware that he is actually Peter, eventually growing some respect for him.
 * Elizabeth "Liz" Allan - one of MJ and Gwen's friends who is a cheerleader and used to date Flash until when TBD.
 * Sally Avril - one of MJ and Gwen's classmates who is a skilled gymnast and somehow intelligent, seeming to dislike Peter due to his status as a nerd and a TBD.
 * Cindy Moon/Silk - a Korean American teenage girl who is bitten by the same spider as Peter, being now able to TBD.
 * Anya Corazon/Spider-Girl - a Hispanic American teenage girl who is known for her intelligence and acquires her powers through a ritual after almost being killed, using them to TBD.
 * J. Jonah Jameson - the arrogant and egocentric editor-in-chief of the Daily Bugle who has started a grudge against Spider-Man, fearing that he may be a menace for society. However, he's still pure-hearted as he is actually afraid of the city being haunted by even worse menaces.
 * Elizabeth "Betty" Brant - Jameson's calm secretary who TBD.
 * Joseph "Robbie" Robbertson - a high-ranking editor at the Daily Bugle who TBD.
 * Edward "Ned" Leeds - a reporter who TBD.
 * Capt. George Stacy - the captain of the New York Police Department and Gwen's father who, unlike Jameson, considers that Spider-Man is a true hero and an essential help to fight crime.
 * Officer Jefferson Davis - Miles' father who cares about him and TBD.
 * Det. Jean DeWolff - TBD
 * Det. Yuriko "Yuri" Watanabe - a Japanese American detective who becomes intrigued about Spider-Man and sometimes TBD.
 * Rio Morales - Miles' mother who works as an EMT and TBD.
 * Lee Stanley - a news reporter who is known for his rather comedic jokes and often reports on Spider-Man or the villains' acts. He's is modeled after Spider-Man ' s co-creator Stan Lee who died shortly before the comic's release.
 * Dr. Martha Connors - Curt's wife who is a scientist as well and tries to find a cure for his mutation as she occasionally TBD.
 * John Jameson/Man-Wolf - Jameson's son who is a NASA astronaut and TBD.
 * Felicia Hardy/Black Cat - a jewel thief who is known for giving bad luck to her adversaries and often teases and flirts with Peter just to TBD.
 * Silver Sablinova/Silver Sable - a Symkarian mercenary for hire who starts out as antagonist for a while until she eventually understood that Spider-Man is not a TBD.
 * Alexis Munday/Deadly Bat - an immortal anti-hero who was raised in a family of assassins and eventually turns against them, using her skills to sometimes fight crime or in some cases commit some.
 * Harriet Garcia/Slinger - Spider-Man's biggest fan who develops an armor using her brains and wit to be a heroine and save the day from A.I.M. and other threats.

Antagonists

 * Dr. Norman Osborn/Green Goblin - the head of OsCorp who is Harry's father and Lena's uncle, dealing with unstable mentality after being exposed to an experimental serum by taking the mantle of Green Goblin, almost immediately becoming de facto Peter's arch-nemesis.
 * The Sinister Six, consisting of:
 * Dr. Otto Octavius/Doctor Octopus - an incredibly intelligent but myopic mad scientist who is obsessed to prove that he is the greatest mind around by attaching four robotic tentacles into himself to cause TBD.
 * Flint Marko/Sandman - TBD
 * Maxwell "Max" Dillon/Electro - TBD
 * Adrian Toomes/Vulture - TBD
 * Sergei Kravinoff/Kraven the Hunter - a Russian hunter who is known for hunting with his bare hands and aims for TBD.
 * Quentin Beck/Mysterio - TBD
 * Roderick Kingsley/Hobgoblin - TBD
 * Dr. Curtis "Curt" Connors/Lizard - a genetic biologist and a friend of Peter who was mutated into a lizard-like creature, ending up to become TBD.
 * Edward "Eddie" Brock/Venom - an investigative journalist who bonds with an alien symbiote, becoming a feral and extremely dangerous creature who wants Peter dead for causing his firing from the Daily Bugle after it was revealed he was falsifying some facts to degenerate Spider-Man's reputation.
 * Anne Weying/She-Venom - a district attorney and Eddie's fiancée who gains a bond with another symbiote, leading to become TBD.
 * Cletus Kasady/Carnage - TBD
 * Wilson Fisk/Kingpin - the most powerful mob boss in New York City who develops a grudge against Peter for taking his drug and TBD.
 * Elektra Natchios - an assassin hired by Kingpin to kill anyone who TBD.
 * Avery Chance/Syren - a siren-like villainess who can hypnotize anyone who stands up against her, either male or female, by simply looking at them.
 * Lonnie Lincoln/Tombstone - an albino mob enforcer who is known for having a TBD.
 * Silvio Manfredi/Silvermane - TBD
 * Martin Li/Mr. Negative - TBD
 * MacDonald "Mac" Gargan/Scorpion - TBD
 * Alexander "Alex" O'Hirn/Rhino - a deranged military officer who goes on a rampage to TBD.
 * Hannibal Afternor/The Dragon King - an insane man who becomes obsessed with legends and develops TBD.
 * The Enforcers, consisting of:
 * Jackson Brice/Montana - the leader of the Enforcers who TBD.
 * Daniel Brito/Fancy Dan - TBD
 * Raymond Bloch/Ox - TBD
 * Miles Warren/Jackal - TBD
 * Herman Schultz/Shocker - TBD
 * Calypso - an African shaman who gave Kravenoff his powers to TBD.
 * Anthony "Tony" Masters/Taskmaster - TBD
 * Dr. Lorina Dodson/White Rabbit - TBD
 * Nathaniel Jorda/Batter - a rogue baseball player who TBD.
 * Jackson Weele/Big Wheel - a businessman who TBD.
 * Ulysses X. Lugman/The Slug - a fat mob boss who has more TBD.
 * Dr. Mendel Stromm - a former OsCorp employee who gains the power of TBD.
 * Dr. Jackson Avrad/Will o' the Wisp - TBD

Differences

 * Aunt May and Uncle Ben are slighty younger, being in their mid 50s.
 * Peter, Harry, MJ, Gwen and, at a minor extent, Flash and Liz know each other since they were children.
 * The Green Goblin failed to kill Gwen as Peter achieves to save her just in time by webbing TBD.
 * Several villains are supporting characters under the effects of a drug created by Kingpin.

Issues

 * 1) /With Great Power/ - Set some weeks after the radioactive spider incident, teen prodigy Peter Parker starts his career as Spider-Man as a way to cope with the authorities by heading after TBD.
 * 2) /Comes Great Responbility/ - Shortly after Uncle Ben's death, Peter decides to avenge his death by continuing his quest to establish himself as TBD as he meets an obese mob boss known as Slug.
 * 3) /Big Wheeled/ - Peter ends up to find an eccentric criminal who uses a big wheel to TBD.
 * 4) /A Sandy Problem/ - TBD
 * 5) /Illusion/ - TBD
 * 6) /Octopus/ - TBD
 * 7) /Webbed Love/ - After facing the Taskmaster, MJ discovers by accident that Peter is Spider-Man as he tries to be sure that she retains it as a secret and that she stays away from any harm. At the moment, the Taskmaster plans to use her as a TBD.
 * 8) /Electric!/ - TBD
 * 9) /Night of the Goblin/ - TBD
 * 10) /Project: King/ - A new drug developed by Fisk causes the mutation several people's genes, also turning them evil. Peter attempts to find a counter drug but is first stopped by the Lizard as he is out to take him out TBD.
 * 11) /Face It Tiger/ - While continuing his hunt to take down Kingpin's drug, Peter learns that MJ has used the drug, ending up to become a mutant tiger, being forced to kill Peter due to the mind controlling effects of the drug. As a result, Peter must defeat her against his will and find a cure for her status before it's too late.

Trivia

 * The comic is not canon to the current continuity, being set in its own continuity.
 * The continuity where the comic is set is named Earth-357427.
 * The creators of the comic opted to not kill Gwen in this continuity as they considered that the event was getting old and repetitive in most Spider-Man media and due to her increase in popularity in recent years.