Osmosis Jones 2

Osmosis Jones 2 is the sequel to Osmosis Jones and takes place from 1 year to 16 years after the first film.

Plot
After one year that Thrax was defeated once and for all, Osmosis Jones and Leah Estrogen continued their relationship as he still continues to fight illness in the City of Frank as an Immunity Officer. On a special evening, Ozzy decided to bring Leah to a picnic at the Frank National Park. As sunset approaches after a whole evening of fun, Ozzy had a special surprise for Leah: a sparkling heart-shaped diamond ring he held out while bending his knees on the grass proposing to Leah. She agrees and gave Ozzy a huge kiss like her expected one for Ozzy at the wedding.

Outside the body, Frank Detorre is now a healthy man still raising his now 11-year-old daughter Shane.

Cells

 * Chris Rock as Osmosis Jones
 * David Hyde Pierce as Drix Koldreliff
 * Laurence Fishburne as Thrax
 * Brandy Norwood as Leah Estrogen-Jones
 * Alexis Amodio as Michelle Leah Jones