Fluke: Bigger and Better

 is an American science fiction-comedy video game, being the fourth installment of the Fluke video game series. It is developed and published by Warner Bros. Interactive Entertainment and will release on June 4th, 2021.

Main

 * Fluke (voiced by Mark Hamill) - a purple, virus-shaped creature who was part of an experiment gone wrong.
 * Anna Lois Carmichael (voiced by Janice Kawaye) - a human woman who works as a private investigator that encounters Fluke and ends up befriending him.

Supporting

 * Luke Jones (voiced by Troy Baker) - a human man who is Anna's love interest.
 * Ludwig (vocal effects by Frank Welker) - a black Labrador who is Anna's pet.

Antagonists

 * Nexus (voiced by Kevin Michael Richardson) - a giant, yellow, virus-shaped creature who is a nemesis of Fluke.
 * Dr. Lena Austin (voiced by Jen Taylor) - a mad scientist who created Nexus to terrorize the place.
 * Dr. Lena Austin (voiced by Jen Taylor) - a mad scientist who created Nexus to terrorize the place.