Osmosis Jones 2: Body Works

Osmosis Jones 2: Body Works is a 2029 American live-action/animated action-adventure comedy film with animated scenes directed by Tom Sito and Gary Trousdale and live-action scenes directed by the Farrelly brothers. Produced by Warner Animation Group, it is a sequel to Osmosis Jones (2001) and stars Chris Rock, David Hyde Pierce, Brandy Norwood, Will Forte, Anthony Mackie, Charlie Sheen, Sarah Paulson, Jimmy Kimmel, Ron Howard, Molly Shannon, Chris Elliott, and Bill Murray. The film is set 7 years after the events of the first film, in which Ozzy and Drix are called into to save the City of Frank from an unknown contagious virus. The film was released on August 10, 2029, by Warner Bros. Pictures. It received mixed reviews from critics and grossed over $348 million worldwide.

Synopsis
Set 7 years after the events of the first film, Ozzy and Drix, now partners, are called into action when an unknown contagious virus invades the City of Frank, with intentions on killing Frank's entire immune system.

Cast
Animation voice cast Live-action cast
 * Chris Rock as Osmosis "Ozzy" Jones, a blue and white blood cell who works for the City of Frank Police Department.
 * David Hyde Pierce as Drixenol "Drix" Koldreliff, a red and yellow cold pill who is Ozzy's partner and best friend.
 * Brandy Norwood as Leah Estrogen, a former secretary for Mayor Phlemming and Ozzy's girlfriend.
 * Will Forte as an unknown contagious virus that invades the City of Frank, often called "The Virus That Cannot be Named".
 * Anthony Mackie as Eddie Jones, Ozzy's widowed father.
 * Charlie Sheen as Dale Williams, a rookie for the City of Frank Police Department.
 * Jimmy Kimmel as Todd, Drix's twin brother.
 * Ron Howard as Tom Colonic, the current mayor of the City of Frank.
 * Joel Silver as the police chief, Ozzy and Drix's boss.
 * William Shatner as Phlegmming, the ex-mayor of the City of Frank.
 * Bill Murray as Frank Detorre, a zookeeper at Detorre's Zoo, Bob's brother, and Shane's father.
 * Sarah Paulson as Shane Detorre, Frank's 20-year old daughter. She was previously portrayed by Elena Franklin in the first film.
 * Molly Shannon as Mrs. Boyd, Shane's former P.E. teacher who falls in love with Frank.
 * Chris Elliott as Bob Detorre, Frank's brother, Shane's uncle, and the owner of Detorre's Zoo.