Spider-Man: What's Up Danger?

 is an American animated action-adventure superhero television series, being based on ', itself based on ' by Marvel Comics. It is produced by Marvel Animation and Disney Television Animation and it airs on Disney Channel since October 12th, 2020.

Synopsis
Miles Morales is an average teenager living in Brooklyn, until he gets bitten by a radioactive spider as he becomes the newest Spider-Man in the now deceased Peter Parker's image, dealing with various deadly threats.

Main

 * Miles Morales/Spider-Man (voiced by Zeno Robinson) - an African American-Hispanic teenager who gets bitten by a radioactive spider and becomes his own superhero, dealing with his own situations.

Supporting

 * Jefferson Davis (voiced by Gary Anthony Williams) - Miles' overprotective father who is a police officer and wants to make sure his son is safe, being unaware that he is Spider-Man.
 * Rio Morales (voiced by Alanna Ubach) - Miles' mother who is an EMT and equally cares for her son's safety and cares about her husband as well.
 * Ganke Lee (voiced by Dante Basco) - Miles' geeky best friend who figures out his secret identity as the Spider-Man and aids him in his heroic crusade.
 * Lana Baumgartner/Bombshell (II) (voiced by Liliana Mumy) - the daughter of the first Bombshell who was originally a member of the gang called the Bombshells until she redeems herself and starts working as a minor heroine, having a crush on Miles.
 * J. Jonah Jameson (voiced by Mark Hamill) - a former detractor of Spider-Man who is now going through a crisis as he somewhat supports the new Spider-Man yet shows a sign of concern for New York's safety, trying to make sure Spider-Man doesn't screw up.

Antagonists
Note: * means they are made for the show.


 * Aaron Davis/Prowler (voiced by Khary Payton) - Miles' uncle who is a masked criminal named the Prowler and becomes obsessed with the Spider-Man, being unaware that he is his own nephew.
 * Lee Price/Venom (voiced by [Troy Baker, Yuri Lowenthal, Roger Craig Smith, Steven Blum, Gideon Emery, Travis Willingham, Xander Mobus, Liam O'Brien, Nolan North or TBD]) - a seemingly pathetic thug who bonds with the now hostless Venom as he shows a near sadistic love of violence.
 * The Sinister Seven, consisting of:
 * Eduardo Lobo (voiced by Danny Trejo) - a Hispanic mob boss who can turn himself into a werewolf and uses it to commit crimes, eventually forming a team of Spider-Man's most dangerous enemies known as the Sinister Seven.
 * Maximus Gargan/Scorpion (voiced by John DiMaggio) - a thug who wields a chain with a "stinger" and calls himself the brand new Scorpion.
 * Elias Wirham/Cardiac (voiced by DC Douglas) - a surgeon who has been transformed into a deadly threat capable of controlling heartbeats as he wants revenge on those who turned him into a beast.
 * Lorena Dobson/White Rabbit (voiced by Cristina Vee) - an intellectual and stuck up student in Miles' school who soon becomes obsessed with Alice In Wonderland, becoming a full blown high tech terrorist.
 * Avery Chance/Syren* (voiced by TBD) - a criminal who is capable of controlling people with her voice as she uses her powers to force people to commit various crimes for her as she soon becomes interested in Spider-Man due to him being immune to her powers.
 * Francine Frye/Electro (voiced by TBD) - a party animal teenager who gets into an accident, becoming the new Electro as she wants to turn New York into a never ending party without adults to shut her and her supposed passion down.
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 * Jake Nash/Shade (voiced by Matthew Mercer) - a convict who turned himself into a living darkness out to kidnap people to return to his normal form as he is considered to basically be a ghost.
 * Kateri Deserti/Coldheart (voiced by Grey Griffin) - a former military soldier who after witnessing her son die in the battle that killed Spider-Man, heads after the new Spider-Man, claiming his death will avenge her son.
 * Klaus Schmidt/The Mad Bomber* (voiced by Jason Spisak) - a mad criminal who stole a bunch of bombs and plans to blow up New York for his twisted idea of fun.
 * Leona Michaels/Tarantula Hawk* (voiced by Ashley Johnson) - a teenage girl obsessed with Spider-Man as she steals an experimental suit just to impress him but ends up getting rejected by him and now wants to prove that she is better and more powerful than him.
 * Lori Baumgartner/Bombshell (I) (voiced by Tara Strong) - Lana's mother who is a professional criminal and after her daughter's defection to the good side, gets obsessed with getting her daughter back to her no matter what.
 * Clayton Cole/Clash (voiced by Josh Keaton) - an obsessive man who was the original Spider-Man's biggest fan, now blaming both J. Jonah Jameson and the new Spider-Man for the first Spider-Man's death and heads to kill them both.
 * Richard Deacon/Human Fly (voiced by TBD) - a normal scientist who is obsessed with flies as he willingly mutates himself into a fly-monster as he becomes an extremely deranged and feral beast.
 * Samantha Braxton/Slime* (voiced by TBD) - a thug who worked for Eduardo Lobo who gets mutated into becoming made out of slime, making her immune to several attacks due to her slime-like composure.
 * Black Fox (voiced by Rodger Bumpass) - an elderly jewel thief who mentored Aaron as he decides to rejoin the stealing game as he surprisingly has access to a lot of high tech.
 * Charlie Wiederman/Molten Man (voiced by Max Mittelman) - a bullied student who volunteers to be injected with a serum which turns him into a heat based being, seeking revenge on those who bullied him in the past.
 * Hannibal Evermore/Dragon King* (voiced by TBD) - a historian who believes that he is a reincarnation of a God as he uses technology to advance his goals of being worshipped like a god.
 * Martin Blank/Gibbon (voiced by Eric Bauza) - an outcast of society who was shamed due to his both resemblance to a monkey and his extreme levels of agility who grows to hate regular human society and wants them all to die.
 * Edward Lansky/Lightmaster (voiced by TBD) - an insane scientist who mutates into a villain capable of controlling pure light as it causes him to grow increasingly unstable.
 * Fritz Von Meyer/Swarm (voiced by TBD) - an eccentric German scientist who willingly transforms himself into a swarm of bees as he commits crimes to show off his intellectual superiority.

Episodes
See List of episodes.

Trivia

 * The series mixes several lesser known Spider-Man villains with villains created for the show.
 * Each episode has a title based on a song from various genres including rap, pop and musicals as well as titles based on movies, shows and video games.