Clifford: The Big Red Mystery

Clifford: The Big Red Mystery is a 2025 American 3D live-action/computer-animated mystery comedy film based on the Clifford the Big Red Dog books by Norman Bridwell and the Sherlock Holmes stories by Sir Arthur Conan Doyle. The film stars the live-action talents of Leslie Mann, Megan Fox, Hugh Jackman, James Corden, Kelly Macdonald, Jim Broadbent, Kevin Hart, Ben Stiller, Christina Applegate, and Seth Rogen, with the voices of Ryan Reynolds, Will Ferrell, Jenny Slate, Michael Caine, Owen Wilson, and Idris Elba. In the film, a murder has broken out in Birdwell Island with the Howard family as the suspected culprits, and it is up to Clifford and his friends to figure this out, with the help of Sherlock Holmes, John Watson, and Irene. Walt Becker, director of Alvin and the Chipmunks: The Road Chip (2015), another hybrid, directs this film with Mark Mothersbaugh as composer. It was produced by New Line Cinema, Warner Animation Group, Marv Films, Red Hour Productions, and was released on May 16, 2025, by Warner Bros. Pictures. The film was a critical and commercial success, grossing over $777 million on an $80 million budget.

Synopsis
When a murder is broken out in Birdwell Island and the Howards are thought to be the culprits, Clifford the Big Red Dog and his friends will team up with Sherlock Holmes to figure out the true culprit and solve the mystery.

Cast
Live-action cast Voice cast
 * Leslie Mann as Emily Elizabeth Howard, Clifford's kind human owner who has kept him for 9 years.
 * Megan Fox as Jetta Handover, Emily's best friend and Mac's human owner who is snobby, but loving.
 * Hugh Jackman as Sherlock Holmes, a famous British detective who can talk to dogs.
 * James Corden as Dr. John Harold Watson, Sherlock's friend and partner in crime-solving.
 * Kelly Macdonald as Irene Adler, Sherlock's girlfriend.
 * Jim Broadbent as Professor James Moriarty, Sherlock's arch-enemy and the true mastermind behind the murder in Birdwell Island.
 * Kevin Hart as Charlie, a former Jamaican-American soccer player and one of Emily's best friends.
 * Ben Stiller as Vaz, a former clumsy and shy boy who is one of Emily's best friends.
 * Christina Applegate as Caroline Howard, Emily's mother.
 * Seth Rogen as Mark Howard, Emily's father.
 * Chris Rock as Samuel, Charlie's father who runs and operates a fish and chips restaurant on the Birdwell Island boardwalk.
 * Jonah Hill as Sheriff Lewis, the sheriff of Birdwell Island and T-Bone's owner.
 * Tiffany Haddish as Mrs. Diller, Cleo's owner who works as a fashion designer.
 * Russell Crowe and Shirley MacLain as Horace and Violet Bleakman, the Howard's's next-door neigbors, respectively.
 * Antonio Banderas and Michael Pena as Pedro and Victor, a pair of Latin-American maintenance workers, respectively.
 * Ryan Reynolds as Clifford the Big Red Dog, a giant red Labrador Retriever/Vizsla cross.
 * Will Ferrell as T-Bone, an orange and yellow bulldog with a large appetite.
 * Jenny Slate as Cleo, a sarcastic bur good-looking purple poodle.
 * Michael Caine as Mac, a British blue greyhound.
 * Owen Wilson as K.C., a three-legged lemon beagle who now has a fourth prosthetic leg to make him walk better.
 * Idris Elba as Basin, a Jack Russell Terrier and Moriarty's pet.