Marvel: All New, All Different Chronicles/Characters

A full list of characters in Marvel: All New, All Different Chronicles. The show shares the animation tone of The Avengers: Earth's Mightiest Heroes!.

New Champions
A group composed of young heroes composed of Spider-Man and his friends, who aspire to be the next generation of Avengers.


 * Spider-Man / Peter Parker
 * Voice Actor/Actress: Haley Joel Osment
 * Biography: A 16-year-old gifted genius teenager who earned spider-like abilities after being bitten by a radioactive spider. Initially a student at Midtown High School, he now enrolls at the Baxter Institute alongside his friends. He is also the field leader of the New Champions.
 * Appearance: Based on Tom Holland's character in the Marvel Cinematic Universe, but with blue eyes.
 * Tigra / Mary Jane Watson
 * Voice Actor/Actress: Ashley Johnson
 * Biography: Peter's 15-year-old girlfriend and a human/alien hybrid (daughter of F.E.A.S.T. nurse Mary Watson and Titanian Tiger Soto) who can shape-shift into a humanoid tigress with the abilities of Fire and Ice Breath, Hypnosis and the “strength of ten tigers combined” (provided with Superhuman Strength, wall climbing, Superhuman leaping, and able to run and swim in incredible speeds). She can also use a technique called the "Maharaja's Roar", on which she lets out a powerful roar which can conjure wind and fire and summon the astral projection of a tiger head (presumably that of its namesake tiger god). This power can be used in both human and Titanian Tiger form. Like Peter and the most of his friends, she enrolls as a top student of Baxter Institute.
 * Appearance: The same as in Ultimate Marvel: Earth-2, and animated after the females in The Avengers: EMH!.
 * Falcon / Sam Wilson
 * Voice Actor/Actress: Bumper Robinson
 * Biography: One of Peter Parker's friends who went on a summer trip in Africa to experience a life of adventure. During his trip, he came across an artifact called the Mask of Horus. Just then, Sam was given a vision of bird life and woke up learning he gained a superhuman intellect, enhanced eyesight, and the ability to communicate with birds. He soon participated the Wakanda Air Games hosted by Zuri and won first place in every single one of them. Impressed by his skills, the Wakandans nicknamed him "Kozi" (which means "falcon"). He was awarded by T'Challa and Shuri a Wakandan flight suit with special functions and arsenal and artificial Vibranium wings which can be summoned at will. Sam now operates as the superhero Falcon and is one of Spider-Man's hero companions.
 * Appearance: The same as in Ultimate Marvel: Earth-2, and animated after the males in The Avengers: EMH!.
 * Starforce / Elizabeth “Liz” Danvers Rogers
 * Voice Actor/Actress: Dove Cameron
 * Biography: The 15-year-old daughter of Steve Rogers / Captain America and Carol Danvers / Captain Marvel. She is also one of Peter Parker's friends, Mary Jane's best friend and operates as Starforce, a young patriot with the same physical strengths of her parents as well as the abilities to harness Vibranium, liberate Photonic energy and project weapon-based astral constructs. As a normal citizen, Liz enrolls at the Bilderberg Academy, a girls-only school which is said to be one of Midtown High's old rivals.
 * Appearance: The same as in Ultimate Marvel: Earth-2, and animated after the females in The Avengers: EMH!.
 * Ms. Marvel / Kamala Khan
 * Voice Actor/Actress: Kathreen Khavari
 * Biography: Aamir's younger half-sister and a 12-year-old Inhuman with size and shape-shifting abilities who idolizes Captain Marvel. While she was raised by her mother in a beach house, she still visits her brother Aamir in their father's village.
 * Appearance: The same as in Ultimate Marvel: Earth-2, and animated after the females in The Avengers: EMH!.
 * Goliath / Ned Leeds
 * Voice Actor/Actress: Eric Bauza
 * Biography: Peter's best friend and classmate from Baxter Institute, he became Goliath after donning his own prototype of Dr. Hank Pym's Quantum Particle suit, which increases his physical strengths and allowing him to manipulate his own size and access the Quantum Realm.
 * Appearance: Visually based on Jacob Batalon's character in the Marvel Cinematic Universe. His Goliath suit is a red and black variant of the Avengers' time travel suit from Avengers: Endgame.
 * Lightyear / Luke Potts Stark
 * Voice Actor/Actress: Robbie Daymond
 * Biography: The 18-year-old son of Tony Stark and Pepper Potts who sports his own Iron Man suit designated as "Lightyear". He is also one of Peter Parker's friends, one of Spider-Man's superhero companions and is in a romantic relationship with Sally Avril.
 * Appearance: Visually the same of his counterpart from Ultimate Marvel: Earth-2. His Lightyear suit is similar to Harry Osborn's Patrioteer suit in Ultimate Spider-Man vs. the Sinister 6, but with the visor colored in silver.
 * Wave / Michelle Jones
 * Voice Actor/Actress: Alanna Ubach
 * Biography: One of Peter Parker's friends and an aspiring professional swimmer who (due to exposure to an Oscorp Super Soldier formula which accidentally fell in a Oscorp pool she was swimming at for experimentation during the shootout between Norman Osborn's bodyguards and Otto Octavius' mercenaries) developed water-bending abilities and superhuman speed running and swimming. Despite terrified with her mutations, Michelle became inspired by Peter's heroic actions as Spider-Man and became the new heroine Wave. She is also a top student in Baxter Institute, and is frequently making water-based experiments.
 * Appearance: The same of her counterpart from Ultimate Marvel: Earth-2.
 * Stormranger / Teresa Parker
 * Voice Actor/Actress: Jessie Flower
 * Biography: Peter's long lost 12-year-old younger sister who was born eight months after her parents left Peter to the care of Uncle Ben and Aunt May. On the wake of her parents' death by the hands of criminals working for Norman Osborn, Teresa took up her father's secret project, which includes technology resources from both Stark Industries and the Kree Empire. Soon after, she donned a new flight nanosuit (which includes the same functions of Tony Stark's Iron Man suit, as well as camouflage and phasing functions) with arm blades and optic beams and begun to operate as the new superheroine Stormranger in hopes of bringing the murderers of her parents to final justice and reuniting with her brother. Successful with her goal, Teresa now lives with Peter and Aunt May and enrolls at Bilderberg Academy alongside Liz.
 * Appearance: Visually a young girl with dirty blonde hair and blue eyes. Her Stormranger suit is a one piece leotard silver variant of the Ironheart suit in the comics added with platinum wings, a golden mask with sapphire visors and blue artificial hair.
 * Kid Arachnid / Miles Morales
 * Voice Actor/Actress: Nadji Jeter
 * Biography: A 13-year-old Spider-Man fan who is imbued with spider-like abilities after being bitten by a mutated spider. He is Spider-Man's own protege and sidekick.
 * Appearance: Visually the same as in his animated show counterparts. His costume is detailed after the one worn in Spider-Man: Into the Spider-Verse, added with a red hood.
 * Edith
 * Voice Actor/Actress: Tara Strong
 * Biography: An naive, but peaceful A.I. system which is loyal to Peter and his friends.
 * Appearance: She has no official form of her own, although she is most seen inhabiting a white and blue robot body based on a barn owl.
 * Stature / Gwen Stacy
 * Voice Actor/Actress: Mae Whitman
 * Biography: Scott Lang's 12-year-old niece and surrogate daughter who was orphaned by the shootout between Norman Osborn's bodyguards and Otto Octavius' mercenaries. She became Stature after coming in possession of a prototype Quantum Realm particle suit of her own, which uses similar functions of her uncle's Ant-Man suit, but also added with electro-blasts which she can shoot out of her gloves.
 * Appearance: Visually the same as in Ultimate Spider-Man, and animated after the females in The Avengers: EMH!. Her Stature suit is a white one-piece leotard with blue boots and gloves and a mask similar to Starforce's.
 * Skynet / Carlie Cooper
 * Voice Actor/Actress: Tara Strong
 * Biography: A 14-year-old robotic prodigy who is one of Peter Parker's friends and classmates in Baxter Institute, she came in contact with a symbiote-like nanite suit of Kree technology which can manipulate and absorb technology and analyse and mimic the abilities of Inhumans, and operates as Skynet. She uses a nanotech suit of her own making to control the substance.
 * Appearance: Visually a younger version of her Earth-616 counterpart, with a pony-tail hairstyle and without the glasses. Her Skynet form is a teenage variant of Jocasta in the comics with blue eyes. Her remote-control nanosuit is a barefoot white one-piece leotard with a blue orb in her chest place.
 * American Knight / Randy Robertson
 * Voice Actor/Actress: Zeno Robinson
 * Biography: One of Peter Parker's friends and classmates in Baxter Institute, and a science prodigy who battles crime with a Vibranium-powered exosuit which mimics Captain America's Super Soldier strength and projects virtual weapons (primarily swords and shields).
 * Appearance: Visually the same as in Marvel's Spider-Man, but with a shaved hair and without the glasses. His American Knight suit is a exosuit based on a Medieval Era knight's armor with the colors of Captain America's suit.
 * Lightning Panther / Shuri
 * Voice Actor/Actress: Daisy Lightfoot
 * Biography: King T'Challa's 14-year-old younger sister, the Princess of Wakanda who designs new technology for her country. She also has the metahuman ability to generate and manipulate electricity and wields a Vibranium armor suit of her own making in battle as the Lightning Panther. She is a genuine friend to Peter Parker and his classmates and, after joining the Champions' team, currently enrolls as a student in Baxter Institute, much to everyone's joy (and Harry Osborn's dismay and objections).
 * Appearance: Visually based on her counterpart from Marvel Rising, and animated after the females in The Avengers: EMH!.. Her Lightning Panther suit is a one piece leotard version of her MCU and MR counterparts' battle suits added with a violet facial mask with the face of a panther.
 * Nova / Sam Alexander
 * Voice Actor/Actress: Antony Del Rio
 * Biography: Miles' 13-year-old best friend and classmate who became a member of the Nova Corps after finding a Nova Corps helmet which once belonged to his father.
 * Appearance: The same as in Ultimate Spider-Man Season 3 and 4, and animated after the males in The Avengers: EMH!.
 * Nocturnal
 * Voice Actor/Actress: Yuri Lowenthal
 * Biography: A native from Pegasus Z and a young Inhuman with owl-like appearance and attributes and the abilities of camouflage and to emit superhuman sound waves from his voice.
 * Appearance: The same of his counterpart from Marvel's Spider-Man Season 2, and animated after the males in The Avengers: EMH!.
 * El Diablo
 * Voice Actor/Actress: Steve Blum (in a Spanish accent)
 * Biography: An altered, highly intelligent red Tyrannosaurus Rex from Pegasus Z who, due to exposure to Gamma Radiation fluids combined with Vibranium shards during World War II, became a immortal dinosaur with the abilities of Sonic Wave roar and Nuclear Breath. In more modern eras, he had begun wearing a special armor of technology from Stark Industries, the Kree Empire and the Chitauri. He is also a loyal ally to Earth's superheroes (including Captain America, who was one of his war allies, and the Hulk) and the New Warroirs' guardian.
 * Appearance: The same as in Ultimate Marvel: Earth-2, and animated after the males in The Avengers: EMH!.

Avengers
A group composed of Earth's Mightiest Heroes, who dedicate their lives protecting their world from several threats which no hero can fight alone.


 * Captain America / Steve Rogers
 * Voice Actor/Actress: Roger Craig Smith
 * Biography: The leader of the Avengers and a World War II veteran, who was enhanced to the peak of human physicality by an experimental serum and frozen in suspended animation before waking up in the modern world. Along with his iconic Vibranium Shield (which has been his main weapon since World War II), Rogers also wields a pair of special Wakandan gauntlets provided for him by the Wakandan Design Group in memory of king Azzuri. He is a mentor to Spider-Man and his friends, and is married to Carol Danvers, with whom he has a teenage daughter named Liz.
 * Appearance: The same as in Avengers Unleashed.
 * Captain Marvel / Carol Danvers
 * Voice Actor/Actress: Jennifer Hale
 * Biography: An Avenger and U.S. Air Force pilot whose DNA was fused with that of Kree scientist Mar-Vell during an accident, which imbued her with the powers of superhuman strength, energy projection and flight. She is married to Steve Rogers and they have a teenage daughter named Liz.
 * Appearance: The same as in Ultimate Marvel: Earth-2, and animated after her appearance in The Avengers: EMH!.
 * Goose
 * Voice Actor/Actress: N/A
 * Biography: A Flerken and Danvers' pet, with whom she has a symbiotic, psychic link. Also thanks to their symbiotic link, Goose (after replicating some bit of Danvers' powers) became able to shape-shift into a hulking feline beast with increased strength and the ability to liberate Photonic energy from her mouth.
 * Appearance: The same as in Avengers: Inhumans Unleashed.
 * Iron Man / Tony Stark
 * Voice Actor/Actress: Mick Wingert
 * Biography: The second-in-command and benefactor of the Avengers who is a self-described genius, billionaire, playboy, and philanthropist with electromechanical suits of armor of his own making. He is also a mentor to Peter Parker and his friends as well as the benefactor of Baxter Institute.
 * Appearance: The same as in Avengers Unleashed.
 * Thor
 * Voice Actor/Actress: Travis Willingham
 * Biography: An Avenger and the former crown prince of the destroyed world of Asgard, based on the Norse mythological deity of the same name. While he works on battling crime and potential threats on Earth, Thor also spends his time overseeing and looking after Asgard's refugees who are taking shelter on Earth. He and Groot are also the creators of Pegasus Z, a paradise island created for homeless Mutants and Inhumans to be their safe haven. He had lost his right eye during a battle against Dark Elf Algrim / Kurse. During the events of season 2, he earns the powerful Uru sword Twilight, which once belonged to his father Odin.
 * Appearance: The same as in Ultimate Marvel: Earth-2, and animated after his appearance in The Avengers: EMH!.
 * Black Panther / T'Challa
 * Voice Actor/Actress: James C. Mathis III
 * Biography: An Avenger and the king of the African nation of Wakanda, who gained his enhanced strength by ingesting the Heart-Shaped Herb.
 * Appearance: Based on Chadwick Boseman's character in the MCU, and animated after his appearance in The Avengers: EMH!.
 * Phantom Tiger / Aamir
 * Voice Actor/Actress: Eric Bauza
 * Biography: An expanded member of the Avengers and a 21-year-old Inhuman tribesman and shaman who can mimic the abilities of animals (most commonly tigers) and summon astral projections of tigers. He was also trained in the arts of Tae Kwon Do by his father Yusuf and is armed with his Vibranium Tomahawk and astral bow.
 * Appearance: Visually based on Aamir Khan in the Earth-616 comics. His Phantom Tiger outfit is based on the one worn by Nightwolf in Mortal Kombat 11, with red tattoos based on tiger stripes in his arms and face.
 * Redhawk / Katherine "Kate" Bishop
 * Voice Actor/Actress: Ali Hillis
 * Biography: An expanded member of the Avengers, she is a 20-year-old skilled archer, sword-master and paragliding champion who was orphaned by the raid of a Kree squad in Oscorp when she was 6-years-old. Like Peter Parker and his friends, Kate blames the death of her parents on Osborn. Most currently, she battles crimes as Redhawk armed with her Adamantium sword, her trick arrows and technologic bow, and equipped with a advanced Vibranium pod of Stark Technology which provides her with virtual glasses and wings. She is also in a romantic relationship with Phantom Tiger and has a telepathic link with her pet hawk Maverick.
 * Appearance: Visually the same of her Earth-616 counterpart, and animated after the females in The Avengers: EMH!. Her Redhawk suit is a red two piece leotard version of her costume.
 * Maverick
 * Voice Actor/Actress: N/A
 * Biography: An Inhuman red-tailed hawk with enhanced strength and speed and the ability to burst in flames and convert any projectile into a Pyrokinetic bomb. He is Kate's pet and sidekick, with whom she is telepathically linked with.
 * Appearance: The same of any regular red-tailed hawk.
 * Ant-Man / Scott Lang
 * Voice Actor/Actress: Josh Keaton
 * Biography: An Avenger and former petty criminal who acquired a suit which allows him to shrink or grow in scale while also increasing in strength.
 * Appearance: The same as in The Avengers: EMH!, but with his armor from Ant-Man and the Wasp.
 * Black Widow / Natasha Romanoff
 * Voice Actor/Actress: Laura Bailey
 * Biography: An Avenger and highly trained spy working for S.H.I.E.L.D..
 * Appearance: The same as in Avengers Unleashed.
 * Crystal
 * Voice Actor/Actress: Kari Wahlgren
 * Biography: An Avenger, the Princess of Attilan and the second youngest member of the Inhuman Royal Family, who has the ability to control the elements of Earth, Wind, Fire and Water.
 * Appearance: The same as in Avengers Unleashed.
 * Hulk / Bruce Banner
 * Voice Actor/Actress: George Newbern
 * Biography: An Avenger and genius scientist who, because of exposure to Gamma radiation, typically transforms into a monster when enraged or agitated. After a duplicator ray machine caused Banner and Hulk to be separated in individual bodies, Hulk went into hiding while Banner ended up living a life with his wife Sofia Corazon and their daughter Anya until mercenaries under General Ross’ orders implanted a bomb on their house, killing Sofia and severely injuring Banner, leaving only Anya alive. On the brink of death, Banner had his mind and body swapped with those of the Hulk with a mind machine he built so that Banner could expose Ross for his actions and look after Anya while Hulk would die a free monster. 10 years later, Hulk now continues living his life of as a superhero and as a father to Anya. He is also a teacher in Baxter Institute.
 * Appearance: The same as in Ultimate Marvel: Earth-2, and animated after his appearance in The Avengers: EMH!.

Guardians of the Galaxy
A group composed of space adventurers and heroes who protect Earth and other planets from random threats such as Kree Empire forces led by Ronan the Accuser.


 * Star-Lord / Nathan “Nate” Quill
 * Voice Actor/Actress: Scott Menville
 * Biography: The leader of the Guardians and a Baxter Institute student who ended up infused with the energies of an alien gemstone which grants him a symbiotic link with a special star-shaped emblem of alien technology which provides him an special space suit, granting him interstellar abilities (flight, elemental manipulation (Earth, Wind, Fire and Water) and sword and shield astral construct projection) and allows him to summon a highly advanced starship. He is also a friend of Peter Parker and keeper of his identity of Spider-Man, as well as a member of the New Champions. His suit comes from the Star emblem, which can be activated once Nate puts it in his chest. He also has a telepathic link with cosmic-powered bulldog Drax the Destroyer. He also has a passion for music, as he is shown hearing some in his Zune during his adventures.
 * Appearance: Visually a green eyed, short haired brunette. His Star-Lord armor is the same as in Ultimate Marvel: Earth-2.
 * Gamora / Zoe Gillan
 * Voice Actor/Actress: Laura Bailey
 * Biography: The second-in-command of the Guardians, a member of the New Champions and a teenage Chameliel, an alien shapeshifter with superhuman strength and agility, wall-crawling, an accelerated healing factor and the ability to absorb and redirect energy. She is also a master martial artist and talented weapon expert. As a very young child, she was rocketed away from her home planet by her parents during a civil war they did not want her to take part in. Taking shelter on Earth, she took the shape of a human girl and started a life with the Gillan family, earning the name Zoe. As she got older along the way, she became inspired by the actions of Earth's superheroes and became one herself while using her real name Gamora as her superhero code-name. She later became one of Peter Parker's friends, joined the Baxter Institute as a top student and fell in love with Nathan Quill, with whom she is now romantically paired with. She is also shown to share Nate's passion for music.
 * Appearance: The same as in Ultimate Marvel: Earth-2, and animated after the females in The Avengers: EMH!.
 * Drax the Destroyer
 * Voice Actor/Actress: N/A
 * Biography: Once a regular bulldog who was selected as the pilot of an experimental NASA space capsule during the space race and was set to be the first dog in space, a crack in the ship's hull created an explosion which hurled Drax towards a radioactive energy imbalance. As a result, he became able to transform into a feral alien beast with the abilities of increased strength, teleportation and to shoot nuclear energy from his mouth. Two years later, he was soon found and retrieved by Nathan Quill during his first adventure in space as Star-Lord. Therefore, Drax became his loyal companion after they developed a telepathic link. Despite his somewhat hostile, aggressive nature, he is also very friendly to Nathan's friends, including Gamora and Spider-Man. He later became a member of the Guardians.
 * Appearance: The same as in Ultimate Marvel: Earth-2, and animated after the males in The Avengers: EMH!.
 * Rocket Raccoon / James “Bucky” Barnes
 * Voice Actor/Actress: Troy Baker
 * Biography: Steve Rogers' deceased best friend and a army sergeant who was killed during a battle with Hydra in World War II. It was also revealed that Arnim Zola / M.O.D.O.K. had also transferred sergeant Barnes' mind and consciousness into a super-computer for his future experiments. After learning of this, Spider-Man and Star-Lord managed to sneak into Zola's lab and retrieve the flash-drive containing Barnes' consciousness and transferred it into Mech-89P13, a android body resembling a anthropomorphic raccoon and composed of Kree technology, also earning the advanced abilities of a robot/machine, such as Technopathy, increased strength and durability, and shape-shifting into a small, but unstoppable rocket. Barnes adopted the alter-ego of Rocket Raccoon and became a member of the Guardians.
 * Appearance: His human form is based on Sebastian Stan’s character in the Marvel Cinematic Universe. His Rocket Raccoon form is based on Chris Cooper’s version in Ultimate Marvel: Earth-2.
 * Groot
 * Voice Actor/Actress: Travis Willingham
 * Biography: A member of the Guardians and a tree-like humanoid alien and survivor of Asgard. He is Thor's closest friend and once proved himself worthy of wielding Mjolnir. He was given the Uru sword Stormbreaker, which has similar attributes and capabilities to those of Mjolnir. He is also a mentor and friend to Spider-Man and his friends, who are able to understand his native language (on which Groot is only heard saying "I am Groot.", although it actually has other meanings). He and Thor are also the creators of Pegasus Z.
 * Appearance: Based on Vin Diesel's character in the Marvel Cinematic Universe. Stormbreaker is a smaller version of the Double-Edged Sword wielded by Thanos in Avengers: Endgame.
 * Cougar
 * Voice Actor/Actress: N/A
 * Biography: A male Flerken and Gamora's childhood friend (and currently pet) whom she is symbiotically and telepathically linked with. Due to his link with Gamora, Cougar was given the ability to shapeshift into the form of two different "Super-Cats", double-sized hybrids of known wild felines on Earth: a Lion-Tiger which can breathe fire and a Cheetah-Linx which can manipulate electricity.
 * Appearance: Visually based on a Siamese cat. His Lion-Tiger form is a large feline with Lion mane and Tiger stripes. His Cheetah-Linx form is that of a large Linx with Cheetah-colored fur.

Individual

 * Snow Leopard / Sally Avril
 * Voice Actor/Actress: Lacey Chabert
 * Biography: A 17-year-old student and cheerleader in Midtown High School who was raised by Principal Raymond Warren after her parents died. She is a sister-figure to Peter Parker and his only friend from Midtown High. She is later revealed to be an Inhuman/Mutant hybrid when the Terrigen Mist awakened her Inhuman DNA and her Mutant powers, transforming her into a humanoid snow leopard with feline abilities and attributes and the abilities to generate and manipulate ice and cold. Due to her transformation being permanent and her beliefs that everything Warren promised her was a lie, she now lives as a resident of Pegasus Z. She is also in a romantic relationship with Tony Stark's son Luke.
 * Appearance: A young long straight haired brunette with green eyes. As Snow Leopard, her whole body has an snow leopard skin and tail; also (like Cheetah in most DC-centered comics and animated projects), she appears to wear no clothes in her Snow Leopard form.
 * Araña / Anya Banner Corazon
 * Voice Actor/Actress: Kari Wahlgren
 * Biography: Banner's 12-year-old daughter who developed Spider-powers after being bitten by a lab spider recreated by Norman Osborn in Oscorp. She was 2 years old when her mother Sofia was killed by General Ross' mercenaries and her father's mind and consciousness was transferred to that of the Hulk's. Despite her superhero alias of Araña being public knowledge like her father's alias of the Hulk is, she is still accepted as a heroine.
 * Appearance: Visually a child version of her counterpart from the comics. Her Araña outfit is a one-piece leotard version of the one worn by her Earth-982 counterpart.
 * Red Shadow / Katrina “Nat” Romanoff
 * Voice Actor/Actress: Tara Strong
 * Biography: Romanoff's 12-year-old long lost young daughter who was born one year after her mother graduated from her training in the Red Room and was raised by X-Man Colossus for her safety. In present day, after discovering that she shares her mother's willpower and abilities, Kat trained to become a new young vigilante called the Red Shadow.
 * Appearance: Visually a pre-teenage variant of her mother. Her Red Shadow outfit is a red one piece leotard over her black tight pants, a black mask and hood similar to the one worn by Hawkeye in Avengers: Endgame, a pair of long red boots and long red gloves and a black and red logo resembling the taichi symbol.
 * Firestar / Ann-Gell
 * Voice Actor/Actress: Sofia Carson
 * Biography: A Kree/Shi'ar teenage alien hybrid, daughter of renegade Kree captain Mar-Vell and Shi'ar Chancellor Vitana, with the abilities of flight and Pyrokinesis; she also takes the shape of a "living comet" when she is flying in outer space. She is a friend of the New Champions and Guardians of the Galaxy, and has a crush on the X-Men member Iceman.
 * Appearance: Visually a long red-haired, violet-eyed human girl with emerald stripes on her arms and legs. She sports a blue one-piece leotard with long silver boots and fingerless gloves and a golden tiara with a star-shaped logo in it.
 * Human Torch / Jim Hammond
 * Voice Actor/Actress: Jason Marsden
 * Biography: A World War II soldier whose original body was disintegrated and his consciousness was absorbed by Red Skull's Neuro-Cortex gun until his consciousness was transferred to the body of a android clone of Johnny Storm created by Yon-Rogg. He is an ally to Earth's superheroes, and a brother-figure to Firestar.
 * Appearance: His human form is based on Chris Pratt's portrayal of Star-Lord in the MCU. His Human Torch form is a fiery figure with golden eyes.
 * She-Hulk / Jennifer "Jen" Walters
 * Voice Actor/Actress: Grey DeLisle
 * Biography: Banner's cousin, who gained superpowers after receiving a blood transfusion from him following an accident. She is also Ben Grimm's wife, with whom she has a daughter named Daisy.
 * Appearance: The same as in Avengers Unleashed.
 * Quake / Daisy Grimm Walters
 * Voice Actor/Actress: Jessica DiCicco
 * Biography: The 16-year-old daughter of Ben Grimm and Jennifer Walters, who shares her parents' physical strengths and has the abilities to manipulate Earth and Lava. She is best friends with Michelle Jones / Wave.
 * Appearance: A younger variant of her appearance in The Avengers: EMH!. She sports a black one-piece leotard with orange boots and silver bracelets.
 * Golden Jaguar / Felicia Hardy
 * Voice Actor/Actress: Ashly Burch
 * Biography: One of Peter Parker's friends and a young Inhuman with enhanced physical strength and speed, expert Martial arts skills and the ability to shapeshift into a pantanal jaguar with the ability to absorb and redirect energy into concussive blasts which she can fire from her mouth.
 * Appearance: Visually a long blond-haired teen with green eyes. Her costume is a one-piece jumpsuit with a jaguar-colored top and black pants, and a facial white mask with a white hood.
 * Shang-Chi
 * Voice Actor/Actress: James Sie
 * Biography: An immortal samurai and master in the ancient arts of Kung Fu. He is Peter's secret teacher, who trained him in Martial Arts during his first month as Spider-Man.
 * Appearance: The same as in Ultimate Marvel: Earth-2.
 * Lin Lie the Sword Master
 * Voice Actor/Actress: Matthew Yang King
 * Biography: One of Shang-Chi's most recent students and the last descendant of Fuxi who received his ancestor's ancient sword, which has mysterious magical powers.
 * Appearance: The same as in Marvel: Future Fight and animated after the males in the show.
 * TBD
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 * Mar-Vell
 * Voice Actor/Actress: Christopher Daniel Barnes
 * Biography: Ann-Gell's father and a renegade Kree captain who is friends with Danvers.
 * Appearance: The same as in Avengers Unleashed.
 * Cloud 9
 * Voice Actor/Actress: Jennifer Hale
 * Biography: A genetically-modified metahuman girl created by Marla Madison with her own DNA combined with the one of Annabelle Brady, and energy extracted from a alien crystal powered by the element of Air, allowing her the abilities to fly, conjure wind and tornados and create and generate artificial, solid clouds. Initially meant to be a replacement for Dr. Madison's deceased daughter and a living weapon of Oscorp, she was freed by Starforce and Wave to insure she would forge her own destiny. Inspired by the heroes' actions, the clone reinvented herself as Cloud 9 and begun acting as a heroine. Like most homeless Mutants and Inhumans, Cloud 9 currently resides in Pegasus Z, sharing a place with Snow Leopard, and with Firestar, Wave, Lightning Panther and Quake occasionally visiting her.
 * Appearance: Visually the same of Annabelle Brady (see her description bellow). Her suit is a barefoot one-piece violet leotard with a white wind emblem in the chest place.
 * TBD
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 * TBD
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 * Annabelle "Anna" Brady
 * Voice Actor/Actress: Jennifer Hale
 * Biography: One of Liz Danvers Rogers' classmates in the Bilderberg Academy, and the school's reporter. She was initially a student in Midtown High School until she left following a failed interview with Peter Parker about Baxter Institute which was interrupted by Flash Thompson and J. Jonah Jameson. She is a dedicated fan of superheroes (including Spider-Man and his friends as well as the Avengers).
 * Appearance: Visually a long, blond haired teen with green eyes. She is usually shown wearing superhero-based outfits, such as a blue shirt with a heart-shaped Spider-Man face (similar to the one worn by Mary Jane Watson in the comics and in Lego Marvel Super Heroes), a cheerleader uniform with details of Captain America's uniform, and a Captain Marvel costume.

Fantastic Four
A crew of astronauts and outer space explorers who developed their powers following a freak accident in space. They soon became another team of the World's greatest heroes, with the purpose of protecting the innocents from random threats which come by and working to maintain peace with other worlds and keep their surrogate family together.


 * Mr. Fantastic / Dr. Reed Richards
 * Voice Actor/Actress: Alan Tudyk
 * Biography: The leader of the Fantastic Four who has the ability to stretch his body into different forms and lengths. He is one of Peter Parker's idols and mentors and the headmaster of the Baxter Institute, an advanced high school of science and technology for young gifted geniuses.
 * Appearance: The same as in The Avengers: EHM!.
 * Invisible Woman / Susan Storm
 * Voice Actor/Actress: Catherine Taber
 * Biography: The second-in-command of the Fantastic Four and Richards' wife, who has the ability to create and manipulate light, allowing her to create force-fields and turn herself and others objects and people invisible. She acts as a mother-figure for Peter Parker and is a top teacher in the Baxter Institute.
 * Appearance: The same as in Avengers Unleashed.
 * Human Torch / Johnny Storm
 * Voice Actor/Actress: Max Mittelman
 * Biography: The youngest member of the Fantastic Four and Susan's 25 year-old younger brother, who has the ability to mentally create and manipulate fire and fly.
 * Appearance: The same as in The Avengers: EHM!.
 * The Thing / Ben Grimm
 * Voice Actor/Actress: Dave Boat
 * Biography: Richard's best friend and the "muscle man" and pilot of the Fantastic Four, whose body became stone while granting him superhuman strength and durability which match those of the Hulk.
 * Appearance: The same as in The Avengers: EHM!.

X-Men
A group of heroic Mutants who seek to protect the world from random threats while fighting to preserve peace between humanity and the Mutant race.


 * Wolverine / James “Logan” Howlett
 * Voice Actor/Actress: Steve Blum
 * Biography: A member of the X-Men and a Canadian mutant born with hyper-acute, animal-like senses, claws on his hands, and an accelerated healing factor which made it possible to implant a coating of the indestructible metal alloy Adamantium on his skeleton.
 * Appearance: The same as in Wolverine and the X-Men
 * Jean Grey
 * Voice Actor/Actress: Erica Lindbeck
 * Biography: A member of the X-Men and a powerful mutant with Telekinesis and Telepathy, and a teacher at Xavier's Institute.
 * Appearance: The same as in Avengers Unleashed.
 * Storm / Ororo Munroe
 * Voice Actor/Actress: Gina Torres
 * Biography: A member of the X-Men, T'Challa's wife and queen of Wakanda. She is an African Mutant with the ability to manipulate and harness weather at will.
 * Appearance: Based on her appearance in Wolverine and the X-Men, with a one-piece leotard version of her costume.
 * Professor X / Charles Xavier
 * Voice Actor/Actress: Tom Kane
 * Biography: A mutant pacifist and the world's most powerful telepath. He is also a founder of Xavier's School for Gifted Youngsters, and leader of the X-Men.
 * Appearance: The same as in Avengers Unleashed.
 * Cyclops / Scott Summers
 * Voice Actor/Actress: Troy Baker
 * Biography: Jean's fiance and a teacher at Xavier's Institute, he is a Mutant capable of firing uncontrollable beams of concussive force from his eyes and wears a visor to control them.
 * Appearance: The same as in Avengers Unleashed.
 * Iceman / Bobby Drake
 * Voice Actor/Actress: Greg Cipes
 * Biography: A mutant with the ability to generate and manipulate ice and cold.
 * Appearance: The same as in Avengers Unleashed.
 * Colossus / Piotr Rasputin
 * Voice Actor/Actress: Matthew Mercer
 * Biography: A Russian X-Man with the mutant ability to transform his entire body into organic steel. He is a long time ally to Black Widow, who entrusted him to look after her daughter Katrina until the day she was ready.
 * Appearance: The same as in Avengers Unleashed.
 * Shadowcat / Katherine "Kitty" Pryde
 * Voice Actor/Actress: Hynden Walch
 * Biography: Mary Jane's younger cousin, one of Peter Parker`s friends and a student and the hall monitor of Xavier's School for Gifted Youngsters, Kitty is a young mutant with the abilities to phase through matter and walk through solid objects (she can also fuse with and hide within the shadows of other living beings and subjects with this power) and shape-shift into a humanoid Lynx with increased strength and speed and communicate with felines (both domestic and wild cats).
 * Appearance: The same of her counterpart from Ultimate Marvel: Earth-2, and animated after the characters in Avengers: EMH!.
 * Beast / Dr. Hank McCoy
 * Voice Actor/Actress: Travis Willingham
 * Biography: A mutant with leonine attributes, prehensile feet and superhuman physical abilities. Hank acts as a teacher in Xavier's school and he builds inventions for troubled students and is the builder of the X-Jet. He is also a teacher in Baxter Institute.
 * Appearance: The same of his counterpart from Ultimate Marvel: Earth-2, and animated after the characters in Avengers: EMH!.

Inhuman Royal Family
A group composed of Inhumans who are the main residents and leaders of the people of Attilan. They are close allies to Earth's superheroes against common threats in the galaxy.


 * Black Bolt
 * Voice Actor/Actress: Roger Craig Smith
 * Biography: The Head of the Inhuman Royal Family who is the King of Attilan, whose voice can cause destruction with the slightest whisper, and is a mentor to the young Inhumans on Earth. While he cannot speak with his mouth, he still speaks with humans and Inhumans through Telepathy.
 * Appearance: The same as in Avengers Unleashed.
 * Medusa
 * Voice Actor/Actress: Erica Lindbeck
 * Biography: Crystal's older sister, Black Bolt's wife and Queen of Attilan, who has the ability to control and move her hair and has a telepathic link with Black Bolt.
 * Appearance: The same as in Avengers Unleashed, but with the costume of Serinda Swan's character in the Inhumans live-action series.
 * Luna
 * Voice Actor/Actress: Jessica DiCicco
 * Biography: The 11-year-old daughter of Black Bolt and Medusa, Crystal's niece, a princess of Attilan and the youngest member of the Inhuman Royal Family, who has the abilities to fly and let out sonic wave blasts from her voice at will. She also shares her mother's ability to control and move her hair.
 * Appearance: Visually a long blond haired blue eyed girl with a cyan star tattoo around her right eye. She sports a barefoot white one piece leotard with the logo of Attilan in her chest place.
 * Karnak
 * Voice Actor/Actress: Robin Atkin Downes
 * Biography: Black Bolt's cousin and closest adviser, who can "see the fault in all things", avoiding errors, and acts as the Royal Family's strategist and philosopher.
 * Appearance: The same as in Avengers Unleashed.
 * Gorgon
 * Voice Actor/Actress: Kevin Michael Richardson
 * Biography: Black Bolt's cousin and leader of Attilan's Royal Guard, who can generate seismic waves with his cattle-like hooves.
 * Appearance: The same as in Avengers Unleashed.
 * Lockjaw
 * Voice Actor/Actress: N/A
 * Biography: Crystal's 2,000-pound (910 kg) canine companion and an Inhuman dog with the teleportation power (as well as other abilities) who serves the Inhuman Royal Family as their escort and as a loyal protector.
 * Appearance: The same as in Avengers Unleashed.

S.H.I.E.L.D. (Strategic Homeland Intervention, Enforcement and Logistics Division)

 * Nick Fury
 * Voice Actor/Actress: Terrence C. Carson
 * Biography: The director of S.H.I.E.L.D. who originally recruited the Avengers and continues to be a mentor and benefactor for the team.
 * Appearance: Based on Samuel L. Jackson's character in the MCU.
 * Maria Hill
 * Voice Actor/Actress: Susan Eisenberg
 * Biography: Fury's second-in-command and a high ranking S.H.I.E.L.D. commander. She also acts as a supervisor to the New Champions.
 * Appearance: Based on Cobie Smulders' character in the MCU.
 * Phil Coulson
 * Voice Actor/Actress: Clark Gregg
 * Biography: An agent within S.H.I.E.L.D. who oversees many of the division's field operations. He is a close ally to the Avengers and long-time fan of Captain America.
 * Appearance: Based on Clark Gregg's character in the MCU.
 * War Wachine / James "Rhodey" Rhodes
 * Voice Actor/Actress: Ogie Banks
 * Biography: An officer in S.H.I.E.L.D. and the U.S. Air Force who is Tony Stark's close personal friend. He operates his own prototype of the Iron Man suit, the War Machine armor. He is also a reserve member of the Avengers and occasional trainer of the New Champions.
 * Appearance: The same as in Avengers: EMH!. His armor has the same details as the one seen in Avengers: Infinity War.
 * Dum Dum Dungan
 * Voice Actor/Actress: Fred Tatasciore
 * Biography: An officer of S.H.I.E.L.D. and is one of the most experienced members of Fury's patrol, known for his marksmanship with rifles and impressive physique.
 * Appearance: Based on on Neal McDonough's character in Captain America: The First Avenger, with modern S.H.I.E.L.D. attire.

Minor Characters

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 * Eugene "Flash" Thompson
 * Voice Actor/Actress: Will Friedle
 * Biography: A repugnant and selfish high school jock who used to bully Peter. He was also Sally Avril's first boyfriend until she broke up with him after she caught him getting kissed in his lips by a cheerleader celebrating the school's football team's last year victory in a championship. He first appears in the two first episodes of Spider-Man's Arc, on which he antagonizes Peter as a "little nobody" and disbelieves the claims that Peter is a friend of Spider-Man, whom Thompson ironically idolizes. He also did not share Norman Osborn's concerns over Peter dropping out of the school to join the Baxter Institute. Initially considered to be the most popular jock in Midtown High, Thompson's popularity eventually begins to collapse after he and J. Jonah Jameson inadvertently interrupt Annabelle Brady's interview with Peter about the Baxter Institute, causing Anna to leave Midtown High and Thompson to get suspended from the upcoming championship. Taking his anger on Jameson over the incident, Thompson's situation eventually gets worse when the Living Brain swaps Thompson's mind and body with Jameson's, causing Thompson to incriminate Jameson by beating up the Daily Bugle employees and trashing their work places until Mary Jane Watson knocked him unconscious and the body swap was reversed. Despite being his former self again, Thompson eventually gets expelled from Midtown High after Jameson (in Thompson's body) incriminated him by getting in a fight against the jocks dressed as Spider-Man and insulting the teachers and cheerleaders.
 * Appearance: Visually based on his Earth-12041 counterpart.

Main Antagonists

 * Thanos
 * Voice Actor/Actress: Michael-Leon Wooley
 * Biography: An intergalactic despot from Titan with a goal to destroy half of every population he invades to "re-balance the universe". He is the main antagonist of the Infinity Arc and the entire Season 1.
 * Appearance: Based on Josh Brolin's character in the Marvel Cinematic Universe. His armor resembles the one worn in Avengers: Endgame.
 * Green Goblin / Norman Osborn
 * Voice Actor/Actress: Jeffrey Combs
 * Biography: A scientist, engineer, billionaire, founder and owner of Oscorp and the benefactor of Midtown High School. Despite worshiped by his son Harry and other students, he is otherwise hated by Peter Parker, who blames him for the incident in Oscorp which led to Uncle Ben's death. From the episode Living Brainstorm, Osborn's brain (and later his mind and body) is possessed by the spirit of the Goblin, slowing transforming him into a sadistic psychopath. The transformation is completed once Goblin has Osborn ingest a serum which hideously mutates his appearance, purging Norman Osborn's persona completely and letting the Goblin in full control.
 * Appearance: Visually based on his appearance in Marvel's Spider-Man 2017 TV series. As Green Goblin, he is visually a human-sized variant of his appearance in Ultimate Spider-Man and sports an armor based on the suit worn by Harry Osborn in Marc Webb's The Amazing Spider-Man 2.
 * The Goblin / Living Brain
 * Voice Actor/Actress: Jeffrey Combs
 * Biography: An sadistic Dark Elf whose consciousness was absorbed by the Living Brain after a failed assault on Earth. Taking control of the Living Brain, the Goblin was soon accidentally reactivated by two A.I.M. agents and went for a rampage before he was defeated by Spider-Man, Mister Fantastic and Edith, but not before the Goblin transferred his consciousness into some bits of Norman Osborn's brain, slowly taking over his body.
 * Appearance: The Goblin is visually a human-sized variant of his appearance in Ultimate Spider-Man, but with a grey skin. His Living Brain body shares similar details of the one seen in Marvel's Spider-Man.
 * Ronan the Accuser
 * Voice Actor/Actress: Jonathan Adams
 * Biography: A high-ranking Kree official who is fanatical about their culture and practices, and is on his own campaign of genocide of other alien races, consequently coming in conflict with heroes like the Avengers and the Guardians of the Galaxy. He also has some intense rivalry with Thanos.
 * Appearance: Based on Lee Pace's character in the Marvel Cinematic Universe.
 * The Beyonder
 * Voice Actor/Actress: John DiMaggio
 * Biography: An interdimensional God-like entity who longs to destroy all Earths.
 * Appearance: Based on his looks in Avengers: Secret Wars.
 * The Serpent
 * Voice Actor/Actress: Robin Atkin Downes
 * Biography: The brother of Odin, uncle of Thor, and the Norse God of Fear.
 * Appearance: The same as in the comics.

The Black Order
A group composed of supervillains who serve Thanos.


 * Amora the Enchantress
 * Voice Actor/Actress: April Stewart
 * Biography: A seductive Asgardian sorceress who has a deadly obsession for Thor. She is Thanos' adopted daughter and the leader for his new Black Order.
 * Appearance: The same as in Avengers Unleashed.
 * Skurge the Executioner
 * Voice Actor/Actress: J. B. Blanc
 * Biography: The Enchantress' faithful servant and bodyguard and a hulking Asgardian viking armed with his large, enchanted, double-bladed battle axe (which allows him a number of abilities including cutting rifts into other dimensions and control over fire and ice which he can project at his enemies) and a pair of large guns. As he is loyal to the Enchantress, he is also a servant of Thanos.
 * Appearance: The same as in Avengers Unleashed.
 * Ultron
 * Voice Actor/Actress: Jim Meskimen
 * Biography: An Artificial Intelligence android created by Thanos to be his lead scientist (a role similar to Decepticon Shockwave in Transformers: Prime).
 * Appearance: The same as in The Avengers: Earth's Mightiest Heroes!.
 * Mysterio / Quentin Beck
 * Voice Actor/Actress: Fred Tatasciore
 * Biography: A former employee of Oscorp who was fired by his executives because of his unstable nature, he is a master of illusions and trickery, the creator of the Elementals and a member of Thanos' Black Order. He was one of the first villains fought by Peter Parker in his first six months as Spider-Man.
 * Appearance: The same as in Ultimate Marvel: Earth-2.
 * Kingpin / Wilson Fisk
 * Voice Actor/Actress: Dave Fennoy
 * Biography: A maniacal crimelord of New York and a member of Thanos' Black Order. He secretly longs to take over Thanos' place as the Black Order's master (a role similar to Starscream in the Transformers franchise).
 * Appearance: Based on his looks in Spider-Man: Into the Spider-Verse, but a few inches shorter.
 * Purple Man / Zebdiah Kilgrave
 * Voice Actor/Actress: James Arnold Taylor
 * Biography: A member of Thanos's Black Order who has telekinetic and telepathic abilities (similar to those of Ebony Maw in the MCU).
 * Appearance: The same as in The Avengers: EMH!, but with Ebony Maw's armor and outfit from Avengers: Infinity War and Avengers: Endgame.
 * Morgan Le Fey
 * Voice Actor/Actress: Nika Futterman
 * Biography: A powerful sorceress from King Arthur's legend, and one of Thanos' enforcers. She is also somewhat jealous of Amora the Enchantress.
 * Appearance: Based on her appearance in Ultimate Spider-Man.
 * Abomination / Emil Blonsky
 * Voice Actor/Actress: Steve Blum
 * Biography: One of Hulk's closest foes and a former officer loaned to General Ross who, lusting for the Hulk's power, was injected with various serums which transformed him into a near-skeletal humanoid monster as powerful as the Hulk himself, but also drove him insane. After being banished from Earth, Blonsky became a member of the new Black Order, serving as Thanos' "beast machine super-soldier".
 * Appearance: Based on Tim Roth's character in The Incredible Hulk.

Shadow Council
A secret cabal of supervillains (consisting of Doctor Octopus, Yellowjacket, Killmonger, Malekith the Accursed and Tiger Shark and led by Madame Masque) with the aim of global conquest by any means necessary.


 * Madame Masque / Whitney Frost
 * Voice Actor/Actress: Courtenay Taylor
 * Biography: A former Hydra scientist who became Madame Masque after discovering a Kree ship with the Ravagers and putting on its control mask to save it from sinking. The mask is advanced technology which gives her the power to connect and manipulate any machines, powered by the ship itself. But due to the mask being unstable for humans (and other non-Kree lifeforms), it drove her mad with power, leading her to desire to change the world by enforcing her will over it. She is Liz Danvers Rogers' former school teacher and currently the leader of the Shadow Council.
 * Appearance: Based on her looks in Avengers: Black Panther's Quest.
 * Doctor "Doc Ock" Octopus / Master Planner / Otto Octavius
 * Voice Actor/Actress: C. Thomas Howell
 * Biography: A scientist who worked to perfect prosthetic limb technology and became a super-criminal called the Master Planner after four mechanical appendages were permanently attached to his back during an accident in his lab (it turned out to be an sabotage by one of Norman Osborn's spies) which also killed his wife Rose, using an intra-cranial neural network to connect them to his nervous system. He was also once a brilliant, but neglectful science teacher in Midtown High School until he was fired and arrested after being exposed to public eyes by Spider-Man and his LMD (disguised as Peter Parker) for his crimes. After being broken out of his cell by Madame Masque and becoming a member of her Shadow Council, Octavius now operates as Doctor Octopus while he still longs for revenge on Osborn for ruining his life.
 * Appearance: Visually based on his last appearance in Ultimate Spider-Man vs. the Sinister 6, and sporting the same attire as in the 2018 Spider-Man video game. Initially as the Master Planner, he wore a black-hooded, red-eyed mask with a robotic face. As Doctor Octopus, he wears his goggles from the comics.
 * Yellowjacket / Darren Cross
 * Voice Actor/Actress: Dwight Schultz
 * Biography: The owner of Cross Technological Enterprises and Pym's sworn business rival, he militarizes a similar version of the Ant-Man technology to create the Yellowjacket suit.
 * Appearance: The same as in Avengers Unleashed.
 * Erik Killmonger / N'Jadaka
 * Voice Actor/Actress: Khary Payton
 * Biography: A Wakandan exile and former U.S. black-ops soldier who seeks to overthrow T'Challa, with his own opinion on how Wakanda should be ruled. He is armed with his own version of T'Challa's energy absorbing suit which, reminiscent of his comic book counterpart, has pronounced fangs and glows gold when being used.
 * Appearance: Based on Michael B. Jordan's character in Black Panther.
 * Malekith the Accursed
 * Voice Actor/Actress: Quinton Flynn
 * Biography: One of Thor's old foes and the ruler of the Dark Elves of Svartalfheim.
 * Appearance: Based on Christopher Eccleston's character in Thor: The Dark World.
 * Tiger Shark
 * Voice Actor/Actress: Fred Tatasciore
 * Biography: An Atlantean exile and a vicious humanoid shark who rebelled against Atlantis in protest of the peace treaty between his homeland and the surface world. He is a reluctant member of the Shadow Council.
 * Appearance: The same as in Avengers: Black Panther's Quest, and animated after the males in Avengers: EMH!.

Hydra

 * Red Skull / Johann Schmidt
 * Voice Actor/Actress: Liam O'Brien
 * Biography: The head and creator of Hydra and Captain America's arch-nemesis.
 * Appearance: Based on his appearance in Avengers: EMH!.
 * Sinthea Schmidt
 * Voice Actor/Actress: April Stewart
 * Biography: A German orphan who was raised by Skull as his own daughter and grew up becoming his personal agent.
 * Appearance: The same as in the comics.
 * Madame Hydra / Viper / Ophelia Sarkissian
 * Voice Actor/Actress: Erica Luttrell
 * Biography: A high-ranking general of Hydra who, after injecting herself with an stolen Super Soldier serum combined with Dr. Curt Connors' Lizard formula, became able to shape-shift into a monstrous humanoid snake with increased strength, a large snake tail replacing her right arm and the ability to spit acid venom. She is a formidable foe to the Avengers and Tigra's arch-nemesis. Like Sally Avril in her Snow Leopard form, she wears no clothes in her transformation.
 * Appearance: The same as in Ultimate Marvel: Earth-2.
 * Arnim Zola
 * Voice Actor/Actress: Armin Shimerman
 * Biography: A Nazi biochemist during World War II who survived into the modern age by transferring his conscious mind into the body of a sophisticated robot which protected it by storing it in its chest and displaying a digital image of Zola's face on its chest plate.
 * Appearance: The same as in Avengers Unleashed.

Individual Villains

 * Maximus Boltagon
 * Voice Actor/Actress: Matthew Mercer
 * Biography: Black Bolt's treacherous brother, who has a strong devotion to the people of Attilan and a desire to be king himself. Maximus lost the Inhuman gene when going through the Terrigenesis process, which led to the character being looked down on by other Inhumans.
 * Appearance: The same as in Avengers Assemble and Ultimate Spider-Man, but with the animation of The Avengers: EMH!.
 * Hobgoblin / Harry Osborn
 * Voice Actor/Actress: Sam Riegel
 * Biography: Norman Osborn's dedicated son and the class president in Midtown High School, he secretly operates as the Hobgoblin, equipped with an armored suit created by Oscorp which includes a glider, pumpkin bombs and a heat sword. Contrary to most incarnations where Peter and Harry are best friends, Peter is shown to have more distant relationship with Harry in the show, as Peter blames Harry's father for Uncle Ben's death and Harry (much like his father) does not approve Peter's enrollment at Baxter Institute.
 * Appearance: Visually a teenage variant of his father with hazel-eyes and red-hair. His Hobgoblin suit is based on the one seen in Marvel's Spider-Man.
 * TBD
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 * J. Jonah Jameson
 * Voice Actor/Actress: John DiMaggio
 * Biography: An arrogant journal editor who wrongly criticizes Spider-Man and views him as a menace, and is greedy for Peter Parker's proposal of working for the Daily Bugle to earn the evidence of Spider-Man's identity. He first appears in "Living Brainstorm", on which he interrupts Annabelle Brady's interview with Peter about Baxter Institute greedily demanding him answers of Spider-Man's identity, consequently getting in a fight with Flash Thompson and causing Peter to dismiss them all. After an angered Anna drops out of Midtown High accusing Jameson and Thompson for the incident, Jameson is given a restraining order to keep him away from Peter and any Baxter Institute student. Later after another hostile encounter with Thompson, Jameson witnesses Spider-Man fighting the Living Brain until he and Thompson are accidentally hit by the robot's Neuro-beams. At first, the beam has no apparent effect until it transfers Jameson's mind with Thompson's body, causing Jameson to incriminate Thompson by getting in a fight against the jocks dressed as Spider-Man and insulting the teachers and cheerleaders until Sally Avril knocked him unconscious and the body swap was reversed. Despite being his former self again, Jameson eventually gets fired from Daily Bugle and arrested after Thompson (in Jameson's body) incriminated him by beating up the Daily Bugle employees and trashing their work places.
 * Appearance: The same as in The Avengers: EMH!, but with hazel eyes.

Anti-Heroes

 * Venom / Eddie Brock
 * Voice Actor/Actress: Crispin Freeman (as Eddie Brock) and Kevin Michael Richardson (as Venom)
 * Biography: A disgraced, former Daily Globe journalist who became the current host of an alien Symbiote, which grants him superhuman abilities.
 * Appearance: Based on Tom Hardy's character in the 2018 film Venom.
 * Michael Morbius, the Living Vampire
 * Voice Actor/Actress: Troy Baker
 * Biography: A scientist suffering from a rare blood disease who attempted to cure himself with DNA from vampire bats, but instead became afflicted with a new form of vampirism, giving him superhuman strength, speed, and durability, flight, echolocation, hypnotism, accelerated healing factor and life-force absorption.
 * Appearance: Based on Jared Leto's character in the 2020 film Morbius.
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Stan Lee's Cameos
As in most of current Marvel movies and TV shows, Stan Lee also makes posthumous cameo appearances in several episodes of Marvel: All New, All Different Chronicles. Some cameos are silent and inaudible. Others have dialogues done via archive footage from previous cameos in TV shows, films and video games.

Spider-Man's Arc

 * “A Better Genius” - Lee makes appears at the end of the episode as the concierge in Baxter Institute who welcomes Peter to the new school.
 * “Living Brainstorm” - Lee accompanies Annabelle "Anna" Brady after she leaves Midtown High to join the Bilderberg Academy while comforting her over her failed interview with Peter Parker in Roxxon. Lee later gives a disappointed look at Flash Thompson, as he knows Thompson and J. Jonah Jameson had inadvertently disrupted Anna's interview by mocking Peter and greedily demanding answers about Spider-Man's identity respectively.