The Matthesons

In 1993, Carl Andy, Jr. (under his stage name CAJ) produced an English dub of the 1988-89 anime adaptation of Osomatsu-kun by Fujio Akatsuka for the cable channel Comedy Central. Only 15 of the 86 episodes were aired before quietly being cancelled. It's main difference from the original version was it's reliance on American pop culture references and breaking the fourth wall as well as changing the setting from Japan to "An Ordinary American town that happens to have Japanese written all over it".