Scooby-Doo and the Mystery, Inc.!

 is an American adult animated adventure-mystery-thriller-comedy television series based on  by Hanna-Barbera, being developed by [DCAU alumni]. It is produced by Hanna-Barbera Productions, Warner Bros. Animation and Williams Street and it airs on Adult Swim since June 18th, 2018.

Synopsis
Four teenage best friends find a dog known as Scooby-Doo as they learn they have a knack for mystery solving as they have to deal with both "monsters" and a conspiracy that might change all of Coolsville.

Main

 * Scooby-Doo (voiced by Frank Welker) - a mysterious yet goofy and cowardly dog who bonds with Shaggy and the rest of Mystery, Inc., helping them with mysteries.
 * Norville "Shaggy" Rogers (voiced by Matthew Lillard) - a nervous teenager who gets frightened around both strangers and terrifying objects, starting to bond with Scooby as well as liking to eat food.
 * Fred Jones (voiced by Darren Criss) - a popular yet kind teenager who can be a bit both of a jerk and paranoid as he becomes the unofficial leader of Mystery, Inc. and a bit obsessed with trapping monsters.
 * Daphne Blake (voiced by America Ferrera) - a rich yet athletic teenager who has a crush on Fred and doesn't want to be seen as just a shallow rich person as she kind of likes mystery solving.
 * Velma Dinkley (voiced by Kimiko Glenn) - a nerdy teenager who absolutely loves both studying and several games and cartoons as despite this she doesn't believe in the supernatural, yet helping Mystery, Inc. due to liking to hang with her friends.

Supporting

 * Frank Jones (voiced by Freddie Prinze, Jr.) - Fred's hardworking father who is a construction worker as he is hardly able to see his son but still cares for him and his safety.
 * Victoria Jones (voiced by Sarah Michelle Gellar) - Fred's protective mother who really loves her son and wants him to be safe, occasionally gets overprotective of him.
 * Connor Rogers (also voiced by Matthew Lillard) - Shaggy's goofy and fun-loving father who is the mayor of Coolsville and despite his goofy demeanor, cares for the city.
 * Cecily Rogers (voiced by Amy Poehler) - Shaggy's mother who is really concerned for his son as she wants to make sure that he is safe and making friends.
 * CJ Dinkley (voiced by Gary Cole) - Velma's giddy father who really likes making his daughter happy, as well as helping his wife run the Dinkley Museum.
 * Emi Dinkley (voiced by Ming-Na Wen) - Velma's mother who is a Japanese immigrant as she decides to open a museum of wonders, although she cares for her daughter.
 * Thorn (voiced by Elizabeth Gillies) - a cynical and sarcastic student who is the lead singer of the rock band known as the Hex Girls, often encountering Mystery, Inc.
 * Luna and Dusk (voiced by Keke Palmer and [sass], respectively) - Thorn's two best friends and co-performers as Luna is a little more bubbly and Dusk is a little more snarky, although they like to perform with their best friend.
 * Sheriff Morton Holloway (voiced by Jess Harnell) - the eccentric sheriff of Coolsville who doesn't fully trust Mystery, Inc., but often arrests the culprits anyways.
 * Vincent van Ghoul (voiced by Alan Tudyk) - a B-list horror movie star who all of Mystery, Inc. likes to watch his movies, although they occasionally cross paths.
 * Crystal (voiced by [pretty supportive of him]) - a friendly and bubbly student who has a crush on Shaggy and is eventually revealed to be an alien scientist who wants to study humans.
 * Amber (voiced by Jennifer Hale) - Crystal's pet dog who really loves to hang out with her owner, also being an alien.

Antagonists

 * Zachary Blake (voiced by ) - Daphne's cold father who is the owner of an influential oil company as he is the leader of a secret order that rules Coolsville in the shadows, wanting to free a supposed ancient entity trapped beneath Coolsville.
 * Sonia Blake (voiced by Maria Canals-Barrera) - Daphne's more shallow and fame-obsessed mother who loves her wealth and knows of her husband's more sinister dealings and is willing to cover it up.
 * Reggie "Red" Herring (voiced by Ben Schwartz) - a rude student who has a rivalry against Fred as he occasionally ends up becoming a suspect, even when he has no involvement.

Monsters

 * Danica Monmoth/The Black Knight Ghost (voiced by TBD as Danica and Kevin Michael Richardson as the Black Knight) - the spirit of a dark knight who haunts the Wickles Manor in Coolsville. He is revealed to be, Danica, a maid who worked for Jeremiah Wickles who grew envious at him and his fortune, wanting to kill him and his heirs to get the fortune for herself.
 * Winston Carlyle/Spooky Space Kook (voiced by TBD as Winston and TBD as the Space Kook) - the main villain of the B-horror movie The Spooky Space Kook as he suddenly came to life and begins to assault the filming of a sequel. He is revealed to be Winston, a toxic fan of the original movie who wants to cancel the production of the sequel due to believing that a modern take would butcher the original.
 * Cosgood Creeps and Cutthord Crawls/The Specters (voiced by TBD and TBD respectively as Creeps and Crawls and Steve Blum as the Specters) - two terrifying ghosts who have haunted the home of Beauregard Sanders, wanting to kill all those who may receive his will. They are revealed to be two crooked lawyers who worked for Beauregard Sanders as after his unfortunate death, became the ghosts to make sure they are the sole inheritors of his will.
 * [Captain Cuttler]
 * [Gator Ghoul]
 * [other monsters to return: Tar Monster, Ghost Clown, Chickenstein, 100,000 Volt Ghost, The Creeper, Redbeard, Ghost of Elias Kingston, the Phantom Racer, the Witch and Zombie, Mamba Wamba, Ghost of Lao Tzu and the Scare Pair, the Luna Ghost, Jaguaro, Old Iron Face or TBD, 1, 2 or 3 more]
 * [Ghost Witch of Old Salem]
 * Emile Mondavarious/The Horrendous Beast (voiced by Jason Isaacs) - a massive monster who has been attacking the slowly dying amusement park known as Spooky Island. He is revealed to be the hack owner of the Spooky Island who resorted to disguising himself as a monster to try and bring new publicity to his park.

Episodes
See List of episodes.

Trivia

 * Daphne and Velma are portrayed as biracial in this series, both from their maternal side, with Daphne being Hispanic American and Velma being Japanese American.
 * Save for Scooby and Shaggy (who kept their regular voice actors), most of the cast is voiced by celebrity actors instead as the developers wanted to distinguish it from the main series by reflecting it is a darker incarnation.
 * Despite that, Grey Griffin (Daphne's regular voice actress) and Jennifer Hale (Thorn's regular voice actress) still provide additional voices for the series, with the latter also reprising her role as Amber from The Alien Invaders.
 * While the developers still opted to make one of the lead's relatives, they opted to make Daphne's this time as they justified that making Fred's relatives evil again (like Mystery Incorporated and Be Cool) would get repetitive as they also stated that making either Shaggy's or Velma's would feel weird.