An Octopus is My Best Friend

, also known as Disney's , is an American animated television series created by Catherine Uhlman. It is being created by Walt Disney Television Animation and Disney Channel Originals and aired on Disney Channel from July 2nd, 2004 until November 21st, 2008.

Synopsis
A teenage girl and her octopus best friend embark on adventures in the fictional city of Hitsonville, Michigan.

Main

 * /Shirley Mason/ (voiced by Alyson Stoner) - a teenage girl who is cheerful and very helpful and generous. She is confirmed to be bisexual.
 * /Octo/ (voiced by Billy West) - an optimistic, comedic, and happy-go-lucky octopus who has an ability to breathe in land, as well as Shirley's best friend.

Supporting

 * Jason Mason (voiced by Gregg Berger) - a dimwitted man who is Shirley's father. Despite his stupidity, he deeply cares for his kids, and tries to make sure they are safe.
 * Drake Mason (voiced by Tara Strong) - a mischevious little boy who likes messing with his sister and Octo.
 * /Taylor Ortiz/ (voiced by Mae Whitman) - a tomboyish teenage girl who is one of Shirley's close friends, who is also very fond of sports and whatnot. She is confirmed to be a lesbian and starts to have feelings for Shirley, and in season 4, they become a couple.
 * Jayden MaCoy (voiced by Phil LaMarr) - a chill yet extremely athletic African-American teenager who is one of Shirley's best friends as he likes to work out.
 * Marvin Atkins (also voiced by Billy West) - a comedic yet somewhat pathetic teenager who is one of Shirley's best friends as he often gets on situations.
 * Cindy Brady (voiced by Catherine Taber) - an easily bored teenage girl who is one of Shirley's best friends.
 * Suzy Saunders (voiced by Grey DeLisle) - a cynical and quiet goth girl who is considered to be an outsider as she is seemed to be aggressive.

Antagonists

 * Mary Barron (voiced by Kath Soucie) - a spoiled teenage girl who wants to be the most popular girl in school as she often pokes fun at Shirley and her friends, as well as leading a group of girls who are like Mary.
 * Masie Rangles (voiced by Jennifer Hale) - Mary's idiotic best friend as she is obsessed with being in her good graces, no matter what.
 * Squick (voiced by Jim Cummings) - a rude squid who has been Octo's rival since they were younger.

Episodes
See List of episodes.

Comic book adaption
See Octopus is My Best Friend Forever.

Transcripts
See /Transcripts.

Tropes
See /Tropes.

Trivia

 * It was eventually revealed by the creators that Shirley and Taylor would eventually become a couple.