Digimon: Infection

Digimon: Reign of Mephistomon is an American science fiction action monster film based on the Japanese anime and video game franchise of the same name. It is a sequel/crossover film featuring the cast from the films series consisting of Digimon: Digital Monsters, Digimon: Our War Game, Digimon: The Dark Towers, Digimon: Redemption, Digimon: World Crisis, Digimon: A Million Points of Light and Digimon: Revenge of Diaboromon and the casts from the Netflix series's Digimon Tamers and Digimon Frontier. The film takes elements from the anime Digimon Tamers: Battle of Adventurers.

Plot
After having thought to be destroyed for good, Apocalymon resurfaces and is ultimately chased by Omnimon through the Network. Being too weak to continue in his current form, Apocalymon re-formats himself into his alternate form, Mephistomon. Now more powerful and darker than before, Mephistomon plans revenge by teaming with Daemon and his own Nightmare Soldiers and by shaping reality the way he wants. This cause the worlds of the DigiDestined, Tamers and Spirits to collide. Now all 4 teams must unite to stop Mephistomon once and for all.

DigiDestined

 * Nick Robinson as Tyler "Ty" Kamden
 * Ross Lynch as Matt Jordan
 * Hailee Steinfeld as Sora Taylor
 * Tom Holland as Korbin "Izzy" Isaacs
 * Kathryn Newton as Mimi Tanner
 * Lucas Hedges as Joe Kelvin
 * Jacob Tremblay as T.K. Jordan
 * Mckenna Grace as Kari Kamden
 * Noah Schnapp as Davis Monaghan
 * Lulu Wilson as Yolei Irvine
 * Iain Armitage as Cody Hill
 * Levi Miller as Ken Idle

Digimon

 * Tom Fahn as Agumon and Digmon/Submarimon
 * Kirk Thornton as Gabumon/Garurumon/WereGarurumon/MetalGarurumon/Omnimon (shared with Christian Bale)
 * Meg Donnelly as Biyomon
 * Jeff Nimoy as Tentomon/Kabuterimon/MegaKabuterimon/HerculesKabuterimon
 * Gideon Adlon as Palmon
 * Ezra Miller as Gomamon
 * Elsie Fisher as Patamon
 * Cailee Spaeny as Gatomon/Silphymon (shared with Neil Kaplan)
 * Derek Stephen Prince as Veemon/ExVeemon/Paildramon/Imperialdramon (shared with Paul St. Peter)
 * Neil Kaplan as Hawkmon/Aquilamon/Halesmon/Shurimon/Silphymon (shared with Cailee Spaeny)
 * Tom Hanks as Armadillomon/Ankylomon/Shakkoumon (shared with Henry Cavill)
 * Paul St. Peter as Wormmon/Stingmon/Paildramon/Imperialdramon (shared with Derek Stephen Prince)
 * Kyle Hebert as Greymon
 * Melodee Spevack as Birdramon/Garudamon/Phoenixmon
 * Melissa McCarthy as Togemon
 * Andy Serkis as Ikkakumon/Zudomon/Vikemon
 * Henry Cavill as Angemon/MagnaAngemon/Seraphimon/Pegasusmon/Shakkoumon (shared with Tom Hanks)
 * Amber Heard as Angewomon/Magnadramon/Nefertimon
 * Joseph Pilato as MetalGreymon
 * Zoey Deutch as Lillymon
 * Christian Bale as WarGreymon/Omnimon (shared with Kirk Thornton)
 * Amy Adams as Rosemon
 * Steve Blum as Flamedramon/Raidramon/Magnamon

Tamers

 * Tye Sheridan as Taylor Masterson
 * Brandon Soo Hoo as Henry Wong
 * Katherine McNamara as Rita Norris
 * Ryan Potter as Ryo Akiyama
 * Elle Fanning as Jeri Kaitlyn
 * Aubrey Anderson-Emmons as Suzie Wong
 * KJ Apa as Connor Samson
 * Charlie Heaton as Kenny Kingston
 * Hana Hayes as Alice McCoy

Tamers Digimon

 * Steve Blum as Guilmon/Growlmon/WarGrowlmon/Gallantmon
 * Ashley Johnson as Terriermon/Gargomon/Rapidmon/MegaGargomon
 * Katheryn Winnick as Renamon/Kyubimon/Taomon/Sakyuamon
 * Jason Momoa as Cyberdramon/Justimon
 * Mackenzie Foy as Calumon
 * Vanessa Hudgens as Lopmon/Antylamon
 * Peter Weller as Guardromon/Andromon
 * Millie Bobby Brown as MarineAngemon
 * Keith Szarabajka as Dobermon
 * Derek Stephen Prince as Impmon
 * Aaron Paul as Beelzemon

Spirit DigiDestined

 * Ansel Elgort as Travis Kane/Agunimon/BurningGreymon/Aldamon/EmperorGreymon
 * Nat Wolff as Kody Michaels/Lobomon/KendoGarurumon/BeoWolfmon/MagnaGarurmon
 * Noah Munck as J.P. Smith/Beetlemon/MetalKabuterimon
 * Lili Reinhart as Zoe Oliver/Kazemon/Zephyrmon
 * Pierce Gagnon as Tommy Higgins/Kumamon/Korikakumon
 * Logan Lerman as Chris Michaels/Loweemon/JagerLoweemon
 * Jordan Peele as Bokomon
 * Keegan-Michael Key as Neemon
 * TBA as Susanoomon

Villains

 * Michael Shannon as Mephistomon/Gulfmon
 * Liam Neeson as Apocalymon
 * Liev Schreiber as Daemon
 * Oscar Isaac as NeoDevimon
 * TBA as Bagramon
 * TBA as Barbamon
 * TBA as Karatenmon
 * TBA as Phelesmon
 * TBA as MetalPhantomon
 * TBA as Boltmon

Development
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Pre-production and filming
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Post-production
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Music
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Reception
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Critical reaction
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Box office
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