An Octopus is My Best Friend

, also known as Disney's  is an American animated television series created by Catherine Uhlman. It is being created by Walt Disney Television Animation and Disney Channel Originals and aired on Disney Channel from May 6th 2005 til November 21st, 2008.

Synopsis
A teenage girl and her octopus best friend embark on adventures in the fictional city of Hitsonville, Michigan.

Main

 * Shirley Mason (voiced by Lara Jill Miller) - a teenage girl who is cheerful and sensitive, and is very helpful and generous.
 * Octo (voiced by Billy West) - an octopus who has an ability to breathe in land, as well as Shirley's best friend.

Supporting

 * Jason Mason (voiced by TBD) - a dimwitted man who is Shirley's father. Despite his stupidity, he deeply cares for his kids, and tries to make sure they are safe.
 * Drake Mason (voiced by Tara Strong) - a mischevious little boy who likes messing with his sister and Octo.
 * Taylor Ortiz (voiced by Debi Derryberry) - a tomboyish teenage girl who, despite not liking mostly girly stuff and mainly liking boy-ish stuff, actually likes wearing skirts (wearing a knee length jean skirt) and dresses as well as one of Shirley's close friends, she is confirmed to be a lesbian, and it is hinted that she has feelings for Shirley.
 * Jayden MaCoy (voiced by Phil LaMarr) - a chill African-American teenager who is one of Shirley's best friends.
 * Marvin Atkins (also voiced by Billy West) - a comedic teenager who is also one of Shirley's best friends.
 * Cindy Brady (voiced by Catherine Taber) - an easily bored teenage girl who is one of Shirley's best friends.
 * Henry the Sloth (voiced by Brian Stepanek) - a cartoon sloth who hosts a very friendly educational show Fun Times with Henry!, being Drake's (and secretly Shirley's) favorite show.
 * Suzy Saunders (voiced by TBD) - a cynical and quiet goth girl who usually tends to be snarky towards other teenagers, including Shirley, yet she does have sympathy.
 * William "Billy" Richardson (voiced by Carlos PenaVega) - a smart and intelligent teenage boy who is easily irritated by Shirley, but does find her as a good friend.
 * Anna and Anthony (voiced by TBD and TBD, respectively) - a kind goldfish and a goofy shark who are best friends, living together as roommates and helped Octo escape the aquarium to return to Shirley. It is implied they have a crush on each other.
 * Axy (voiced by TBD) - an axolotl who is in the Hitsonville Aquarium, and one of the sea creatures that helped Octo escape the aquarium.
 * Lobso (voiced by TBD) - a cowardly lobster who is in league with the Aquarium head.
 * Tangy (voiced by TBD) - a flirtatious blue tang.
 * [clownfish]
 * Fenella (voiced by Jessica DiCicco) - a Face Paint girl from the show Fenella, which is Shirley's favorite show.
 * Abigail Allison (voiced by TBD) - a teenage girl who is geeky and likes various TV shows and movies, like sci-fi movies, horror movies, etc.

Antagonists

 * Mary Barron (voiced by TBD) - a spoiled teenage girl who wants to be the most popular girl in school as she often pokes fun at Shirley and her friends, as well as leading a group of girls who are like Mary.
 * [Mary's group]
 * The Dog (vocal effects by TBD) - a crazy dog who has gotten Octo.
 * Harry Williams (voiced by TBD) - a crazy aquarium worker who trapped Octo in the tank when he was lost.
 * Squick (voiced by TBD) - a rude squid who has been Octo's rival since they were younger.

Episodes
See List of episodes.

Comic book adaption
See Octopus is My Best Friend Forever.

Tropes
See /Tropes.