Marvel: All New, All Different Chronicles/Characters

A full list of characters in Marvel: All New, All Different Chronicles. The show shares the animation tone of The Avengers: Earth's Mightiest Heroes!.

New Champions
A group composed of young heroes composed of Spider-Man and his friends, who aspire to be the next generation of Avengers.


 * Spider-Man / Peter Parker
 * Voice Actor/Actress: Haley Joel Osment
 * Biography: A 16-year-old gifted genius teenager who earned spider-like abilities after being bitten by a radioactive spider. Initially a poorly praised student at Midtown High School, he now enrolls as a top student at the Baxter Institute alongside his friends. He is also the field leader of the New Champions.
 * Appearance: Based on Tom Holland's character in the Marvel Cinematic Universe, but with blue eyes.
 * Tigra / Mary Jane Watson
 * Voice Actor/Actress: Ashley Johnson
 * Biography: Peter's 15-year-old girlfriend and a human/alien hybrid (daughter of F.E.A.S.T. nurse Mary Watson and Titanian Tiger Soto) who can shape-shift into a humanoid tigress with the abilities of Fire and Ice Breath, Hypnosis and the “strength of ten tigers combined” (provided with Superhuman Strength, wall climbing, Superhuman leaping, and able to run and swim in incredible speeds). She can also use a technique called the "Maharaja's Roar", on which she lets out a powerful roar which can conjure wind and fire and summon the astral projection of a tiger head (presumably that of its namesake tiger god). This power can be used in both human and Titanian Tiger form. Like Peter and the most of his friends, she enrolls as a top student of Baxter Institute.
 * Appearance: The same as in Ultimate Marvel: Earth-2, and animated after the females in The Avengers: EMH!.
 * Falcon / Sam Wilson
 * Voice Actor/Actress: Bumper Robinson
 * Biography: One of Peter Parker's friends who went on a summer trip in Africa to experience a life of adventure. During his trip, he came across an artifact called the Mask of Horus. Just then, Sam was given a vision of bird life and woke up learning he gained a superhuman intellect, enhanced eyesight, and the ability to communicate with birds. He soon participated the Wakanda Air Games hosted by Zuri and won first place in every single one of them. Impressed by his skills, the Wakandans nicknamed him "Kozi" (which means "falcon"). He was awarded by T'Challa and Shuri a Wakandan flight suit with special functions and arsenal and artificial Vibranium wings which can be summoned at will. Sam now operates as the superhero Falcon and is one of Spider-Man's hero companions, as well as one of the top students in Baxter Institute.
 * Appearance: The same as in Ultimate Marvel: Earth-2, and animated after the males in The Avengers: EMH!.
 * Starforce / Elizabeth “Liz” Danvers Rogers
 * Voice Actor/Actress: Dove Cameron
 * Biography: The 15-year-old daughter of Steve Rogers / Captain America and Carol Danvers / Captain Marvel. She is also one of Peter Parker's friends, Mary Jane's best friend and operates as Starforce, a young patriot with the same physical strengths of her parents as well as the abilities to fly and liberate Photonic energy. Her nanosuit (provided for her by her mother) has Vibranium gauntlets which enable her to project weapon-based astral constructs (mostly swords, spears and shields to her preference). As a normal citizen, Liz enrolls at the Bilderberg Academy, a girls-only school which is said to be one of Midtown High's oldest rivals.
 * Appearance: The same as in Ultimate Marvel: Earth-2, and animated after the females in The Avengers: EMH!.
 * Ms. Marvel / Kamala Khan
 * Voice Actor/Actress: Kathreen Khavari
 * Biography: Aamir's younger half-sister and a 12-year-old Inhuman with size and shape-shifting abilities who idolizes Captain Marvel. While she was raised by her mother in a beach house, she still visits her brother Aamir in their father's village.
 * Appearance: The same as in Ultimate Marvel: Earth-2, and animated after the females in The Avengers: EMH!.
 * Goliath / Ned Leeds
 * Voice Actor/Actress: Eric Bauza
 * Biography: Peter's best friend and classmate from Baxter Institute, he became Goliath after donning his own prototype of Dr. Hank Pym's Quantum Particle suit, which increases his physical strengths and allows him to manipulate his own size and access the Quantum Realm.
 * Appearance: Visually based on Jacob Batalon's character in the Marvel Cinematic Universe. His Goliath suit is a red and black variant of the Avengers' time travel suit from Avengers: Endgame.
 * Lightyear / Luke Potts Stark
 * Voice Actor/Actress: Robbie Daymond
 * Biography: The 18-year-old son of Tony Stark and Pepper Potts who sports his own Iron Man suit designated as "Lightyear". He is also one of Peter Parker's friends, one of Spider-Man's superhero companions and is in a romantic relationship with Sally Avril.
 * Appearance: Visually the same of his counterpart from Ultimate Marvel: Earth-2. His Lightyear suit is similar to Harry Osborn's Patrioteer suit in Ultimate Spider-Man vs. the Sinister 6, but with the visor colored in silver.
 * Wave / Michelle Cage Jones
 * Voice Actor/Actress: Alanna Ubach
 * Biography: One of Peter Parker's friends and an aspiring 16-year-old professional swimmer who (due to exposure to an Oscorp Super Soldier formula which accidentally fell in a Oscorp pool she was swimming at for experimentation during the shootout between Norman Osborn's bodyguards and Otto Octavius' mercenaries) developed water-bending abilities and superhuman speed running and swimming. Despite terrified with her mutations, Michelle became inspired by Peter's heroic actions as Spider-Man and became the new heroine Wave. She is also a top student in Baxter Institute, and is frequently making water-based experiments.
 * Appearance: The same of her counterpart from Ultimate Marvel: Earth-2.
 * Stormranger / Teresa Parker
 * Voice Actor/Actress: Jessie Flower
 * Biography: Peter's long lost 12-year-old younger sister who was born eight months after her parents left Peter to the care of Uncle Ben and Aunt May. On the wake of her parents' death by the hands of criminals working for Norman Osborn, Teresa took up her father's secret project, which includes technology resources from both Stark Industries and the Kree Empire. Soon after, she donned a new flight nanosuit (which includes the same functions of Tony Stark's Iron Man suit, as well as camouflage and phasing functions) with arm blades and optic beams and begun to operate as the new superheroine Stormranger in hopes of bringing the murderers of her parents to final justice and reuniting with her brother. Successful with her goal, Teresa now lives with Peter and Aunt May and enrolls at Bilderberg Academy alongside Liz.
 * Appearance: Visually a young girl with dirty blonde hair and blue eyes. Her Stormranger suit is a one piece leotard silver variant of the Ironheart suit in the comics added with platinum wings, a golden mask with sapphire visors and blue artificial hair.
 * Kid Arachnid / Miles Morales
 * Voice Actor/Actress: Nadji Jeter
 * Biography: A 13-year-old Spider-Man fan who is imbued with spider-like abilities after being bitten by a mutated spider. He is Spider-Man's own protege and sidekick.
 * Appearance: Visually the same as in his animated show counterparts. His costume is detailed after the one worn in Spider-Man: Into the Spider-Verse, added with a red hood.
 * Edith
 * Voice Actor/Actress: Tara Strong
 * Biography: An naive, but peaceful A.I. system which is loyal to Peter and his friends.
 * Appearance: She has no official form of her own, although she is most seen inhabiting a white and blue robot body based on a barn owl.
 * Ghost-Spider / Gwen Stacy
 * Voice Actor/Actress: Mae Whitman
 * Biography: Scott Lang's 12-year-old niece and surrogate daughter who was orphaned by the shootout between Norman Osborn's bodyguards and Otto Octavius' mercenaries. She became Ghost-Spider after coming in possession of a prototype Quantum Realm particle suit of her own, which uses similar functions of her uncle's Ant-Man suit and Peter Parker's Spider-Man technology.
 * Appearance: Visually the same as in Ultimate Spider-Man, and animated after the females in The Avengers: EMH!. Her Ghost-Spider suit is the same as in Iago PUC's version of The Spectacular Spider-Man Season 3, but without her sleeves and with a face mask similar to the one worn by Anya Corazon's Spider-Girl alias in the comics.
 * Stature / Cassandra "Cassie" Lang
 * Voice Actor/Actress: Katie Leigh
 * Biography: Scott Lang's 8-year-old daughter and Gwen Stacy's younger cousin. She became Stature after coming in possession of a prototype Quantum Realm particle suit of her own, which uses similar functions of her uncle's Ant-Man suit, but also added with electro-blasts which she can shoot out of her gloves.
 * Appearance: Visually the same as in The Avengers: EMH!. Her Stature suit is a white one-piece leotard with blue boots and gloves and a mask similar to Starforce's.
 * Skynet / Carlie Cooper
 * Voice Actor/Actress: Tara Strong
 * Biography: A 14-year-old robotic prodigy who is one of Peter Parker's friends and classmates in Baxter Institute, she came in contact with a symbiote-like nanite suit of Kree technology which can manipulate and absorb technology and analyse and mimic the abilities of Inhumans, and operates as Skynet. She uses a nanotech suit of her own making to control the substance.
 * Appearance: Visually a younger version of her Earth-616 counterpart, with a pony-tail hairstyle and without the glasses. Her Skynet form is a teenage variant of Jocasta in the comics with blue eyes. Her remote-control nanosuit is a barefoot white one-piece leotard with a blue orb in her chest place.
 * American Knight / Randy Robertson
 * Voice Actor/Actress: Zeno Robinson
 * Biography: One of Peter Parker's friends and classmates in Baxter Institute, and a science prodigy who battles crime with a Vibranium-powered exosuit which mimics Captain America's Super Soldier strength and projects virtual weapons (primarily swords and shields).
 * Appearance: Visually the same as in Marvel's Spider-Man, but with a shaved hair and without the glasses. His American Knight suit is a exosuit based on a Medieval Era knight's armor with the colors of Captain America's suit.
 * Lightning Panther / Shuri
 * Voice Actor/Actress: Daisy Lightfoot
 * Biography: King T'Challa's 14-year-old younger sister, the genius Princess of Wakanda who designs new technology for her country. She also has the metahuman ability to generate and manipulate electricity and wields a Vibranium armor suit of her own making in battle as the Lightning Panther. She is a genuine friend to Peter Parker and his classmates and, after joining the Champions' team, currently enrolls as a student in Baxter Institute, much to everyone's joy (and Harry Osborn's dismay and objections).
 * Appearance: Visually based on her counterpart from Marvel Rising, and animated after the females in The Avengers: EMH!.. Her Lightning Panther suit is a one piece leotard version of her MCU and MR counterparts' battle suits added with a violet facial mask with the face of a panther.
 * White Wolf / Marcus Thompson
 * Voice Actor/Actress: Cameron Bowen
 * Biography: One of Flash Thompson's estranged younger half-brothers, and Shuri's closest friend. He became White Wolf after obtaining his own Vibranium suit after coming in contact with an ancient amulet which granted him enhanced strength and speed, and the abilities to communicate with canines (dogs, wolves, foxes, etc), and to let out supersonic wave howls. After he and Shuri joined the New Champions as their superhero alter-egos, Marcus and Shuri also enrolled as students in Baxter Institute.
 * Appearance: Visually based on the character Kevin in Marvel Rising: Initiation. His White Wolf attire is a wolf-themed white variant of Black Panther's outfit in Ultimate Avengers 2
 * Nova / Sam Alexander
 * Voice Actor/Actress: Antony Del Rio
 * Biography: Miles' 13-year-old best friend and classmate who became a member of the Nova Corps after finding a Nova Corps helmet which once belonged to his father.
 * Appearance: The same as in Ultimate Spider-Man Season 3 and 4, and animated after the males in The Avengers: EMH!.
 * Nocturnal
 * Voice Actor/Actress: Yuri Lowenthal
 * Biography: A native from Pegasus Z and a young Inhuman with owl-like appearance and attributes and the abilities of camouflage and to emit superhuman sound waves from his voice.
 * Appearance: The same of his counterpart from Marvel's Spider-Man Season 2, and animated after the males in The Avengers: EMH!.
 * El Diablo
 * Voice Actor/Actress: Steve Blum (in a Spanish accent)
 * Biography: An altered, highly intelligent red Tyrannosaurus Rex from Pegasus Z who, due to exposure to Gamma Radiation fluids combined with Vibranium shards during World War II, became a immortal dinosaur with the abilities of Sonic Wave roar and Nuclear Breath. In more modern eras, he had begun wearing a special armor of technology from Stark Industries, the Kree Empire and the Chitauri. He is also a loyal ally to Earth's superheroes (including Captain America, who was one of his war allies, and the Hulk) and the New Warriors' guardian.
 * Appearance: The same as in Ultimate Marvel: Earth-2, and animated after the males in The Avengers: EMH!.

Avengers
A group composed of Earth's Mightiest Heroes, who dedicate their lives protecting their world from several threats which no hero can fight alone.


 * Captain America / Steve Rogers
 * Voice Actor/Actress: Roger Craig Smith
 * Biography: The leader of the Avengers and a World War II veteran, who was enhanced to the peak of human physicality by an experimental serum and frozen in suspended animation before waking up in the modern world. Along with his iconic Vibranium Shield (which has been his main weapon since World War II), Rogers also wields a pair of special Wakandan gauntlets provided for him by the Wakandan Design Group in memory of king Azzuri. He is a mentor to Spider-Man and his friends, and is married to Carol Danvers, with whom he has a teenage daughter named Liz.
 * Appearance: The same as in Avengers Unleashed.
 * Captain Marvel / Carol Danvers
 * Voice Actor/Actress: Jennifer Hale
 * Biography: An Avenger and U.S. Air Force pilot whose DNA was fused with that of Kree scientist Mar-Vell during an accident, which imbued her with the powers of superhuman strength, energy projection and flight. She is married to Steve Rogers and they have a teenage daughter named Liz.
 * Appearance: The same as in Ultimate Marvel: Earth-2, and animated after her appearance in The Avengers: EMH!.
 * Goose
 * Voice Actor/Actress: N/A
 * Biography: A Flerken and Danvers' pet, with whom she has a symbiotic, psychic link. Also thanks to their symbiotic link, Goose (after replicating some bit of Danvers' powers) became able to shape-shift into a hulking feline beast with increased strength and the ability to liberate Photonic energy from her mouth.
 * Appearance: The same as in Avengers: Inhumans Unleashed.
 * Iron Man / Tony Stark
 * Voice Actor/Actress: Mick Wingert
 * Biography: The second-in-command and benefactor of the Avengers who is a self-described genius, billionaire, playboy, and philanthropist with electromechanical suits of armor of his own making. He is also a mentor to Peter Parker and his friends as well as the benefactor of Baxter Institute.
 * Appearance: The same as in Avengers Unleashed.
 * Thor
 * Voice Actor/Actress: Travis Willingham
 * Biography: An Avenger and the former crown prince of the destroyed world of Asgard, based on the Norse mythological deity of the same name. While he works on battling crime and potential threats on Earth, Thor also spends his time overseeing and looking after Asgard's refugees who are taking shelter on Earth. He and Groot are also the creators of Pegasus Z, a paradise island created for homeless Mutants and Inhumans to be their safe haven. He had lost his right eye during a battle against Dark Elf Algrim / Kurse. During the events of season 2, he earns the powerful Uru sword Twilight, which once belonged to his father Odin.
 * Appearance: The same as in Ultimate Marvel: Earth-2, and animated after his appearance in The Avengers: EMH!.
 * Black Panther / T'Challa
 * Voice Actor/Actress: James C. Mathis III
 * Biography: An Avenger and the king of the African nation of Wakanda, who gained his enhanced strength by ingesting the Heart-Shaped Herb.
 * Appearance: Based on Chadwick Boseman's character in the MCU, and animated after his appearance in The Avengers: EMH!.
 * Phantom Tiger / Aamir
 * Voice Actor/Actress: Eric Bauza
 * Biography: An expanded member of the Avengers and a 21-year-old Inhuman tribesman and shaman who can communicate with wild life, mimic the abilities of animals (most commonly tigers) and summon astral projections of tigers. He was also trained in the arts of Tae Kwon Do by his father Yusuf and is armed with his Vibranium Tomahawk and astral bow.
 * Appearance: Visually based on Aamir Khan in the Earth-616 comics, but a bit more muscular. His Phantom Tiger outfit is based on the one worn by Nightwolf in Mortal Kombat 11, but shirtless and with red tattoos based on tiger stripes in his arms and face.
 * Redhawk / Katherine "Kate" Bishop
 * Voice Actor/Actress: Ali Hillis
 * Biography: An expanded member of the Avengers, she is a 20-year-old skilled archer, sword-master and paragliding champion who was orphaned by the raid of a Kree squad in Oscorp when she was 6-years-old. Like Peter Parker and his friends, Kate blames the death of her parents on Osborn. Most currently, she battles crimes as Redhawk armed with her Adamantium sword, her trick arrows and technologic bow, and equipped with a advanced Vibranium pod of Stark Technology which provides her with virtual glasses and wings. She is also in a romantic relationship with Phantom Tiger and has a telepathic link with her pet hawk Maverick.
 * Appearance: Visually the same of her Earth-616 counterpart, and animated after the females in The Avengers: EMH!. Her Redhawk suit is a red two piece leotard version of her Hawkeye purple costume.
 * Maverick
 * Voice Actor/Actress: N/A
 * Biography: An Inhuman red-tailed hawk with enhanced strength and speed and the ability to burst in flames and convert any projectile into a Pyrokinetic/Volcanic bomb. He is Kate's pet and sidekick, with whom she has been telepathically linked with since her childhood.
 * Appearance: The same of any regular red-tailed hawk.
 * Ant-Man / Scott Lang
 * Voice Actor/Actress: Josh Keaton
 * Biography: An Avenger and former petty criminal who acquired a suit which allows him to shrink or grow in scale while also increasing in strength.
 * Appearance: The same as in The Avengers: EMH!, but with his armor from Ant-Man and the Wasp.
 * Black Widow / Natasha Romanoff
 * Voice Actor/Actress: Laura Bailey
 * Biography: An Avenger and highly trained spy working for S.H.I.E.L.D..
 * Appearance: The same as in Avengers Unleashed.
 * Wasp / Hope Van Dyne
 * Voice Actor/Actress: Colleen Villard
 * Biography: An Avenger, Lang's wife and the daughter of Dr. Hank Pym and Janet Van Dyne, who is handed down a similar suit and the Wasp mantle from her mother.
 * Appearance: The same as in Avengers: The Symbiote War and Avengers: Inhumans Unleashed.
 * Ronin / Clint Barton
 * Voice Actor/Actress: Troy Baker
 * Biography: An Avenger and master archer who previously worked as an agent for S.H.I.E.L.D. as Hawkeye until he became a solo fighter on the name of Ronin, a ninja-like vigilante with a Adamantium katana blade, but still retains with arrows and bow.
 * Appearance: The same as in Avengers: Endgame.
 * Crystal
 * Voice Actor/Actress: Kari Wahlgren
 * Biography: An Avenger, the Princess of Attilan and the second youngest member of the Inhuman Royal Family, who has the ability to control the elements of Earth, Wind, Fire and Water.
 * Appearance: The same as in Avengers Unleashed.
 * Hulk / Bruce Banner
 * Voice Actor/Actress: George Newbern
 * Biography: An Avenger and genius scientist who, because of exposure to Gamma radiation, typically transforms into a monster when enraged or agitated. After a duplicator ray machine caused Banner and Hulk to be separated in individual bodies, Hulk went into hiding while Banner ended up living a life with his wife Sofia Corazon and their daughter Anya until mercenaries under General Ross’ orders implanted a bomb on their house, killing Sofia and severely injuring Banner, leaving only Anya alive. On the brink of death, Banner had his mind and body swapped with those of the Hulk with a mind machine he built so that Banner could expose Ross for his actions and look after Anya while Hulk would die a free monster. 10 years later, Banner (still adopting the Hulk alias) now continues living his life of as a superhero and as a father to Anya. He is also a teacher in Baxter Institute.
 * Appearance: The same as in Ultimate Marvel: Earth-2, and animated after his appearance in The Avengers: EMH!.

Guardians of the Galaxy
A group composed of space adventurers and heroes who protect Earth and other planets from random threats such as Kree Empire forces led by Ronan the Accuser.


 * Star-Lord / Nathan “Nate” Quill
 * Voice Actor/Actress: Scott Menville
 * Biography: The 16-year-old leader of the Guardians and a Baxter Institute student who ended up infused with the energies of an alien gemstone which grants him a symbiotic link with a special star-shaped emblem of alien technology which provides him an special space suit, granting him interstellar abilities (flight, elemental manipulation (Earth, Wind, Fire and Water) and sword and shield astral construct projection) and allowing him to summon a highly advanced starship. He is also a friend of Peter Parker and keeper of his identity of Spider-Man, as well as a member of the New Champions. His suit comes from the Star emblem, which can be activated once Nate puts it in his chest. He also has a telepathic link with cosmic-powered bulldog Drax the Destroyer. He also has a passion for music, as he is shown hearing some in his Zune during his adventures.
 * Appearance: Visually a green eyed, short haired brunette. His Star-Lord armor is the same as in Ultimate Marvel: Earth-2.
 * Gamora / Zoe Gillan
 * Voice Actor/Actress: Laura Bailey
 * Biography: The 15-year-old second-in-command of the Guardians, a member of the New Champions and a teenage Chameliel, an alien shapeshifter with superhuman strength and agility, wall-crawling, enhanced leaping and an accelerated healing factor. She is also a master martial artist and talented weapon expert. As a very young child (around 4-years-old), she was rocketed away from her home planet by her parents during a civil war they did not want her to take part in. Taking shelter on Earth, she took the shape of a human girl and started a life with the Gillan family, earning the name Zoe. As she got older along the way, she became inspired by the actions of Earth's superheroes and became one herself while using her real name Gamora as her superhero code-name. She later became one of Peter Parker's friends, joined the Baxter Institute as a top student and fell in love with Nathan Quill, with whom she is now romantically paired with and who occasionally calls her "Zoey". She is also shown to share Nate's passion for music, and mostly dances with him when hearing romantic songs. In battle, Gamora wields (as her primary weapon) the Twilight Talon, a alien sword with the capability to absorb and redirect energy which she found stored in her escape pod by her parents for future protection.
 * Appearance: The same as in Ultimate Marvel: Earth-2, and animated after the females in The Avengers: EMH!. The Twilight Talon resembles Excalibur in Arthurian mythology.
 * Drax the Destroyer
 * Voice Actor/Actress: N/A
 * Biography: Once a regular bulldog who was selected as the pilot of an experimental NASA space capsule during the space race and was set to be the first dog in space, a crack in the ship's hull created an explosion which hurled Drax towards a radioactive energy imbalance. As a result, he became able to transform into a feral alien beast with the abilities of increased strength, teleportation and to shoot nuclear energy from his mouth. Two years later, he was soon found and retrieved by Nathan Quill during his first adventure in space as Star-Lord. Therefore, Drax became his loyal companion after they developed a telepathic link. Despite his somewhat hostile, aggressive nature, he is also very friendly to Nathan's friends, including Gamora and Spider-Man. He later became a member of the Guardians.
 * Appearance: The same as in Ultimate Marvel: Earth-2, and animated after the males in The Avengers: EMH!.
 * Rocket Raccoon / Sebastian Allan
 * Voice Actor/Actress: Troy Baker
 * Biography: An army sergeant and top engineer who was killed during a battle with Hydra in World War II. It was also revealed that Arnim Zola and Red Skull had also transferred sergeant Allan's mind and consciousness into a super-computer for his future experiments. After learning of this, Star-Lord and Gamora managed to sneak into the Jackal's lab within Midtown High School and retrieve the flash-drive containing Allan's consciousness and transferred it into Mech-89P13, a android body resembling a anthropomorphic raccoon and composed of Kree technology, also earning the advanced abilities of a robot/machine, such as Technopathy, increased strength and durability, and shape-shifting into a small, but unstoppable rocket. Allan adopted the alter-ego of Rocket Raccoon and became a member of the Guardians.
 * Appearance: His human form (seen only in flashbacks) is based on Andrew Garfield's portrayal of Desmond Doss in Hacksaw Ridge. His Rocket Raccoon form is based on Chris Cooper’s version in Ultimate Marvel: Earth-2.
 * Groot
 * Voice Actor/Actress: Travis Willingham
 * Biography: A member of the Guardians and a tree-like humanoid alien and survivor of Asgard. He is Thor's closest friend and once proved himself worthy of wielding Mjolnir. He was given the Uru sword Stormbreaker, which has similar attributes and capabilities to those of Mjolnir. He is also a mentor and friend to Spider-Man and his friends, who are able to understand his native language (on which Groot is only heard saying "I am Groot.", although it actually has other meanings). He and Thor are also the creators of Pegasus Z.
 * Appearance: Based on Vin Diesel's character in the Marvel Cinematic Universe. Stormbreaker is visually a smaller version of the Double-Edged Sword wielded by Thanos in Avengers: Endgame.
 * Nebula
 * Voice Actor/Actress: Erica Lindbeck
 * Biography: Gamora's 25-year-old biological older cousin, and a Chameliel who was cybernetically modified and enhanced after being critically injured during the civil war in Zen-Whoberi, which led to her uncle and aunt to rocket Gamora away to Earth for her safety. Years later, Nebula eventually reunited with a grown up Gamora and, after stopping Ronan from destroying their planet, joined the Guardians of the Galaxy, as she states to have no one else in the family but Gamora, and wherever her cousin is, she is home. While approving her cousin's romance with Nathan Quill, Nebula begun forming her own relationship with Groot. Along with Gamora's same powers and abilities, Nebula can also manipulate technology and wields a pair of nanotech bracelets which are tightened in her arms and can summon any weapon she thinks of (most commonly two double-chained blades).
 * Appearance: Visually based on Karen Gillan's character in the MCU, but added with a red cyborg eye for her right eye, a human left red eye, and a long straight dark blue hair with white bangs. She also sports a barefoot black one-piece leotard with a pair of silver bracelets in her arms.
 * Mantis
 * Voice Actor/Actress: Jessica DiCicco
 * Biography: A naive but innocent, genetically engineered alien girl with the abilities of Empathy, Astral Projection, Superhuman Leaping, Healing Factor and Plant Manipulation. Initially a alien insectoid which was discovered by Nathan and Zoe and reanimated in Baxter Institute, Mantis soon reached her full potential after fusing with a humanoid clone originally created by the Kree Empire to be a living weapon before being discarded by Yon-Rogg. Later on, she became a member of the Guardians after helping defeat the Phalanx.
 * Appearance: Initially, a dark green insectoid with light green eyes, the body of a scarab, the head of a ladybug and mantis antennas. In her full form, she is visually a pre-teenaged variant of Pom Klementieff's character in Guardians of the Galaxy Vol. 2 and Avengers: Infinity War, but with Medusa's eye design in Avengers: Black Panther's Quest and pointed, elven ears. She wears a barefoot two-piece dark green leotard, a leaf-made wristlet in her left arm and a blue flower in her hair.
 * Cougar
 * Voice Actor/Actress: N/A
 * Biography: A male Flerken and Gamora's childhood friend (and currently pet) whom she is symbiotically and telepathically linked with. Due to his link with Gamora, Cougar was given the ability to shapeshift into the form of two different "Super-Cats", double-sized hybrids of known wild felines on Earth: a Lion-Tiger which can breathe fire and a Cheetah-Linx which can manipulate electricity.
 * Appearance: Visually based on a Siamese cat. His Lion-Tiger form is a large feline with Lion mane and Tiger stripes. His Cheetah-Linx form is that of a large Linx with Cheetah-colored fur.
 * Eros the Star Fox
 * Voice Actor/Actress: Sean Astin
 * Biography: An extraterrestrial adventurer from Titan and a anthropomorphic male red fox with flight, superhuman strength, speed, stamina and durability, and the abilities to liberate solar energy from mouth and psychically control the emotions of others. He is a close friend to the Guardians of the Galaxy, and eventually joins them when they offer him a home on Earth.
 * Appearance: The same of a regular red fox, with green eyes. He wears a silver necklace with golden star gems in it.
 * Yondu Udonta
 * Voice Actor/Actress: William Salyers
 * Biography: Nathan's mentor, and a blue-skinned Centaurian bounty hunter. A master weapon expert, Yondu's primary weapon is a self-propelled arrow which he can control through whistling. Like Nathan and Zoe, Yondu also enjoys Earth's songs, although he prefers the "classic style" songs (songs from the 80's).
 * Appearance: Based on Michael Rooker's character in Guardians of the Galaxy Vol. 2.

Individual

 * Snow Leopard / Sally Avril
 * Voice Actor/Actress: Lacey Chabert
 * Biography: A 17-year-old student and cheerleader in Midtown High School who was raised by Principal Raymond Warren after her parents died. She is a sister-figure to Peter Parker and his only friend from Midtown High. She is later revealed to be an Inhuman/Mutant hybrid when the Terrigen Mist awakened her Inhuman DNA and her Mutant powers, transforming her into a humanoid snow leopard with feline abilities and attributes and the abilities to generate and manipulate ice and cold. Due to her transformation being permanent and her beliefs that everything Warren promised her was a lie, she now lives as a resident of Pegasus Z, spending her nights and days in Glorian's palace. She is also in a romantic relationship with Tony Stark's son Luke.
 * Appearance: A young long straight haired brunette with green eyes. As Snow Leopard, her whole body has an snow leopard skin and tail; also (like Cheetah in most DC-centered comics and animated projects), she appears to wear no clothes in her Snow Leopard form.
 * Araña / Anya Banner Corazon
 * Voice Actor/Actress: Kari Wahlgren
 * Biography: Banner's 12-year-old daughter who developed Spider-powers after being bitten by a lab spider recreated by Norman Osborn in Oscorp. She was 2 years old when her mother Sofia was killed by General Ross' mercenaries and her father's mind and consciousness was transferred to that of the Hulk's. Despite her superhero alias of Araña being public knowledge like her father's alias of the Hulk is, she is still accepted as a heroine.
 * Appearance: Visually a child version of her counterpart from the comics, with green eyes. Her Araña outfit is a one-piece leotard version of the one worn by her Earth-982 counterpart.
 * Red Shadow / Katrina “Nat” Romanoff
 * Voice Actor/Actress: Tara Strong
 * Biography: Romanoff's 12-year-old long lost young daughter who was born one year after her mother graduated from her training in the Red Room and was raised by X-Man Colossus for her safety. In present day, after discovering that she shares her mother's willpower and abilities, Kat trained to become a new young vigilante called the Red Shadow.
 * Appearance: Visually a pre-teenage variant of her mother. Her Red Shadow outfit is a red one piece leotard over her black tight pants, a black mask and hood similar to the one worn by Hawkeye in Avengers: Endgame, a pair of long red boots and long red gloves and a black and red logo resembling the taichi symbol.
 * Firestar / Ann-Gell
 * Voice Actor/Actress: Sofia Carson
 * Biography: A Kree/Shi'ar teenage alien hybrid, daughter of renegade Kree captain Mar-Vell and Shi'ar Chancellor Vitana, with the abilities of flight and Pyrokinesis; she also takes the shape of a "living comet" when she is flying in outer space. She is a friend of the New Champions and Guardians of the Galaxy, and has a crush on the X-Men member Iceman. Curious, but rather joyful and enthusiastic, she is shown to have a strong affinity for Earth's culture, and enjoys the same free activities of human teenagers.
 * Appearance: Visually based on a long red-haired, violet-eyed human girl with emerald stripes on her arms and legs. She sports a blue one-piece leotard with long silver boots and fingerless gloves and a golden tiara with a star-shaped logo in it.
 * Human Torch / Jim Hammond
 * Voice Actor/Actress: Jason Marsden
 * Biography: A World War II soldier whose original body was disintegrated and his consciousness was absorbed by Red Skull's Neuro-Cortex gun until his consciousness was transferred to the body of a android clone of Johnny Storm created by Yon-Rogg. He is an ally to Earth's superheroes, and a brother-figure to Firestar.
 * Appearance: His human form is based on Chris Pratt's portrayal of Star-Lord in the MCU. His Human Torch form is a fiery figure with golden eyes.
 * She-Hulk / Jennifer "Jen" Walters
 * Voice Actor/Actress: Grey DeLisle
 * Biography: Banner's cousin, who gained superpowers after receiving a blood transfusion from him following an accident. She is also Ben Grimm's wife, with whom she has a daughter named Daisy.
 * Appearance: The same as in Avengers Unleashed.
 * Quake / Daisy Grimm Walters
 * Voice Actor/Actress: Jessica DiCicco
 * Biography: The 16-year-old daughter of Ben Grimm and Jennifer Walters, who shares her parents' physical strengths and has the abilities to manipulate Earth and Lava. She is best friends with Michelle Cage Jones / Wave.
 * Appearance: A younger variant of her appearance in The Avengers: EMH!. She sports a black one-piece leotard with orange boots and silver bracelets.
 * Golden Jaguar / Felicia Hardy
 * Voice Actor/Actress: Ashly Burch
 * Biography: One of Peter Parker's friends and a young Inhuman with enhanced physical strength and speed, expert Martial arts skills and the ability to shapeshift into a pantanal jaguar with the ability to absorb and redirect energy into concussive blasts which she can fire from her mouth. She also wields a pair of wrist blades during hand-to-hand confrontations. She occasionally visits the Glorian's palace in Pegasus Z to attend to his art lessons.
 * Appearance: Visually a long blond-haired teen with green eyes. Her costume is a one-piece jumpsuit with a jaguar-colored top and black pants, and a facial white mask with a white hood.
 * Shang-Chi
 * Voice Actor/Actress: James Sie
 * Biography: An immortal samurai and master in the ancient arts of Kung Fu. He is Peter's secret teacher, who trained him in Martial Arts during his first month as Spider-Man.
 * Appearance: The same as in Ultimate Marvel: Earth-2.
 * Lin Lie the Sword Master
 * Voice Actor/Actress: Matthew Yang King
 * Biography: One of Shang-Chi's most recent students and the last descendant of Fuxi who received his ancestor's ancient sword, which has mysterious magical powers.
 * Appearance: The same as in Marvel: Future Fight and animated after the males in the show.
 * Demolition Fist / Flint Marko
 * Voice Actor/Actress: Travis Willingham
 * Biography: A construction worker who ended up in possession of the Hulk's former Sakaarian gladiator armor set and war-hammer, which he found at work. The armor (which duplicated and contained some bits of Hulk's Gamma DNA) enhanced Marko, imbuing him with tremendous strength and stamina. He now operates as the superhero Demolition Fist.
 * Appearance: A shirtless variant of Flint Marko in the recent Spider-Man shows.
 * Speed / Jack Thompson
 * Voice Actor/Actress: Tara Strong
 * Biography: Flash Thompson's estranged younger half-brother and a 9-year-old boy who developed the abilities of superhuman speed running and electricity absorption and manipulation from a serum containing Quicksilver's DNA combined with the ones of Oscorp's genetic electric eels extracted by the Jackal. Due to his estranged relationship with his Flash, Jack and his second older brother Marcus prefer to live with their more loving cousin Jacqueline Falsworth. He idolizes other heroes like Spider-Man, and is very close friends with Cassie Lang, and the two appear to have hidden feelings for each other.
 * Appearance: The same as in Marvel's Spider-Man: Webbed Champion.
 * Spitfire / Jacqueline Falsworth
 * Voice Actor/Actress: Jennifer Hale
 * Biography: Jack Thompson's older cousin and Flash's mutually estranged younger cousin, she is a 17-year-old Inhuman who can move in supersonic speeds and ignite her body in flames.
 * Appearance: Visually a blonde with blue eyes. As Spitfire, she wears a one-piece leotard version of her original costume in the comics, a pair of golden googles and a Red Headband.
 * Quicksilver / Pietro Maximoff
 * Voice Actor/Actress: Roger Craig Smith (similar to Sonic the Hedgehog's voice)
 * Biography: A young Sokovian who, following an Hydra experiment with the Mind Stone and the Bloodgem, developed the ability to run at supersonic speeds. Despite his superhero alter-ego being public knowledge, he is still praised as a hero.
 * Appearance: Visually based on Aaron Taylor-Johnson's character in Avengers: Age of Ultron, and sporting an white and blue variant of the Avengers' time travel suits from Avengers: Endgame, but with the A-logos replaced for lightning bolt emblems.
 * Mar-Vell
 * Voice Actor/Actress: Christopher Daniel Barnes
 * Biography: Ann-Gell's father and a renegade Kree captain who is friends with Danvers.
 * Appearance: The same as in Avengers Unleashed.
 * Cloud 9
 * Voice Actor/Actress: Hynden Walch
 * Biography: A genetically-modified metahuman girl created by Marla Madison with the DNA of deceased Air Force pilot Abigail "Abby" Boylen combined with the one of Annabelle Brady, and energy extracted from a alien crystal powered by the element of Air, allowing her the abilities to fly, conjure wind and tornados and create and generate artificial, solid clouds. Initially meant to be a replacement for Dr. Madison's deceased daughter and a living weapon of Oscorp, she was freed by Starforce and Wave to insure she would forge her own destiny. Inspired by the heroes' actions, the clone reinvented herself as Cloud 9 and begun acting as a superheroine under the Avengers and New Champions' wings. Like most homeless Mutants and Inhumans, Cloud 9 currently resides in Pegasus Z, sharing a place with Snow Leopard, and with Firestar, Wave, Lightning Panther and Quake occasionally visiting her.
 * Appearance: Visually the same of Annabelle Brady (see her description bellow). Her suit is a barefoot one-piece violet leotard with a white wind emblem in the chest place.
 * Power Man / Luke Cage
 * Voice Actor/Actress: Khary Payton
 * Biography: Michelle's father and a professional boxer who, due to exposure to an Oscorp formula's explosion during the Kree's attack on the facility Kate Bishop's parents died, earned superhuman strength and a unbreakable skin. A close ally to superheroes, Luke is also strongly supportive to his daughter's love for science and swimming.
 * Appearance: Based on Mike Colter's character in Netflix's MCU TV series, and sporting his second outfit from the Ultimate Spider-Man series
 * Moonstone / Jessica Jones
 * Voice Actor/Actress: Kimberly Brooks
 * Biography: Michelle's mother, Luke's wife and a private investigator who, due to exposure to an Kree relic she investigated on Life Foundation, earned the abilities of flight, phasing and the ability to manipulate photonic energy, allowing her to fire concussive beams and conjure an aura which changes her hair color. Like her husband, she is a close ally to superheroes, and also strongly supportive to his daughter's love for science and swimming.
 * Appearance: Based on Krysten Ritter's character in Netflix's MCU TV series, but with green eyes. As Moonstone, she sports her Jewel costume and violet hair and wears blue googles.
 * White Tiger / Ava Ayala
 * Voice Actor/Actress: Caitlyn Taylor Love
 * Biography: Mary Jane's 18-year-old older half-sister who is also a human/Titanian Tiger hybrid and a daughter of Soto with Indian woman Maya Ayala. Her powers are the same as Tigra's. Unlike Mary Jane, who discovered her powers in her teenage years and whose form is based on that of a Bengal tiger, Ava discovered her own when she was 12 years old and her form is based on that of a white tiger.
 * Appearance: Her human form is the same as in the Ultimate Spider-Man TV show and animated after the females in The Avengers: EMH!. Her White Tiger form is a White Tiger variant of Tigra in the comics. Her outfit is a black two-piece leotard with a pair of red laces in her legs and arms. She also has a necklace based on the White Tiger Amulet.
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 * Singularity / Maxine Joan
 * Voice Actor/Actress: Alyson Stoner
 * Biography: A shy and insecure teenage girl who ended up exposed to the radiation of unstable prototype duplicates of the Infinity Stones and became an powerful extraterrestrial entity with abilities associated to the Stones; those including increased strength, durability and concussive energy blasts (Power Stone), flight, teleportation and telekinesis (Space Stone), illusion crafting (Reality Stone), soul tracking and regeneration (Soul Stone), increased speed and Time freezing (Time Stone) and telepathy (Mind Stone). First having occasional, silent appearances in some regular episodes of Season 1's main arcs, she has a expended, central role in the Infinity arc.
 * Appearance: Her human form is a brunette with light cyan eyes. Her Singularity form is based on the same-name character from the A-Force comics, with straight long hair.
 * Cloak / Tyrone Johnson and Dagger / Tandy Bowen
 * Voice Actor/Actress: Ogie Banks (Cloak) and Tara Strong (Dagger)
 * Biography: Two Inhuman teenagers whose power is greater when they are together; Cloak is capable of teleporting in a shroud of Darkforce energy whereas Dagger can generate dagger-like constructs out of Lightforce energy which can also be used to deal wounds and diseases. They primarily reside in Attilan like a majorly of the Inhumans, but they also spend time on Earth socializing with humans and undergoing superhero activities.
 * Appearance: The same as in Ultimate Spider-Man Seasons 3 and 4, and animated after the characters in The Avengers: EMH!.
 * Aunt May
 * Voice Actor/Actress: Jennifer Hale
 * Biography: Peter's aunt and legal guardian, who is aware of and supportive of his double life as a student and as Spider-Man.
 * Appearance: Based on Marisa Tomei's character in the MCU, with blue eyes.
 * Bonnie Quill
 * Voice Actor/Actress: Katie Leigh
 * Biography: Nathan's 6-year-old younger sister. She strongly loves her brother and his friends, including his girlfriend Zoe / Gamora, who treats her well like a little sister.
 * Appearance: Visually based on Morgan Stark in Avengers: Endgame, with blue eyes.
 * Meredith Quill
 * Voice Actor/Actress: Misty Lee
 * Biography: Nathan's mother, who (much like Aunt May for Peter Parker) is aware of and supportive of his double life as a student and as Star-Lord. She also approves her son's relationship with Zoe / Gamora.
 * Appearance: Based on Laura Haddock's character in Guardians of the Galaxy Vol. 2.
 * Glorian
 * Voice Actor/Actress: Robin Atkin Downes
 * Biography: An Asgardian Inhuman and a master craftsman residing in a palace in Pegasus Z. He welcomes orphaned and homeless Mutants and Inhumans to his palace, and occasionally gives them art lessons.
 * Appearance: Based on his appearance in Avengers Assemble.
 * Annabelle "Anna" Brady
 * Voice Actor/Actress: Hynden Walch
 * Biography: One of Liz Danvers Rogers' classmates in the Bilderberg Academy, and the school's reporter. She was initially a student in Midtown High School until she left following a failed interview with Peter Parker about Baxter Institute which was interrupted by Flash Thompson and J. Jonah Jameson. She is a dedicated fan of superheroes (including Spider-Man and his friends as well as the Avengers).
 * Appearance: Visually a long, blond haired teen with violet eyes. She is usually shown wearing superhero-based outfits, such as a blue shirt with a heart-shaped Spider-Man face (similar to the one worn by Mary Jane Watson in the comics and in Lego Marvel Super Heroes) with a red skirt with Iron Man's logo in the wrist, a cheerleader uniform with details of Captain America's uniform, and a Captain Marvel costume.
 * Heimdall
 * Voice Actor/Actress: Ike Amadi
 * Biography: The all-seeing, all-hearing Asgardian sentry of (formerly) the Bifrost Bridge in Asgard who is now the sentry of the cosmic gateway to Pegasus Z, based on the Norse mythological deity of the same name.
 * Appearance: Based on Idris Elba's character in the MCU.

Fantastic Four
A crew of astronauts and outer space explorers who developed their powers following a freak accident in space. They soon became another team of the World's greatest heroes, with the purpose of protecting the innocents from random threats which come by and working to maintain peace with other worlds and keep their surrogate family together.


 * Mr. Fantastic / Dr. Reed Richards
 * Voice Actor/Actress: Alan Tudyk
 * Biography: The leader of the Fantastic Four who has the ability to stretch his body into different forms and lengths. He is one of Peter Parker's idols and mentors and the headmaster of the Baxter Institute, an advanced high school of science and technology for young gifted geniuses.
 * Appearance: The same as in The Avengers: EHM!.
 * Invisible Woman / Susan Storm
 * Voice Actor/Actress: Catherine Taber
 * Biography: The second-in-command of the Fantastic Four and Richards' wife, who has the ability to create and manipulate light, allowing her to create force-fields and turn herself and others objects and people invisible. She acts as a mother-figure for Peter Parker and is a top teacher in the Baxter Institute.
 * Appearance: The same as in Avengers Unleashed.
 * Human Torch / Johnny Storm
 * Voice Actor/Actress: Max Mittelman
 * Biography: The youngest member of the Fantastic Four and Susan's 25 year-old younger brother, who has the ability to mentally create and manipulate fire and fly.
 * Appearance: The same as in The Avengers: EHM!.
 * The Thing / Ben Grimm
 * Voice Actor/Actress: Dave Boat
 * Biography: Richard's best friend and the "muscle man" and pilot of the Fantastic Four, whose body became stone while granting him superhuman strength and durability which match those of the Hulk.
 * Appearance: The same as in The Avengers: EHM!.

X-Men
A group of heroic Mutants who seek to protect the world from random threats while fighting to preserve peace between humanity and the Mutant race.


 * Wolverine / James “Logan” Howlett
 * Voice Actor/Actress: Steve Blum
 * Biography: A member of the X-Men and a Canadian mutant born with hyper-acute, animal-like senses, claws on his hands, and an accelerated healing factor which made it possible to implant a coating of the indestructible metal alloy Adamantium on his skeleton.
 * Appearance: The same as in Wolverine and the X-Men
 * Jean Grey
 * Voice Actor/Actress: Erica Lindbeck
 * Biography: A member of the X-Men and a powerful mutant with Telekinesis and Telepathy, and a teacher at Xavier's Institute.
 * Appearance: The same as in Avengers Unleashed.
 * Storm / Ororo Munroe
 * Voice Actor/Actress: Gina Torres
 * Biography: A member of the X-Men, T'Challa's wife and queen of Wakanda. She is an African Mutant with the ability to manipulate and harness weather at will.
 * Appearance: Based on her appearance in Wolverine and the X-Men, with a one-piece leotard version of her costume.
 * Professor X / Charles Xavier
 * Voice Actor/Actress: Tom Kane
 * Biography: A mutant pacifist and the world's most powerful telepath. He is also a founder of Xavier's School for Gifted Youngsters, and leader of the X-Men.
 * Appearance: The same as in Avengers Unleashed.
 * Cyclops / Scott Summers
 * Voice Actor/Actress: Troy Baker
 * Biography: Jean's fiance and a teacher at Xavier's Institute, he is a Mutant capable of firing uncontrollable beams of concussive force from his eyes and wears a red visor (while in his X-Men uniform) and a pair of sunglasses (in casual clothing) to control them.
 * Appearance: The same as in Avengers Unleashed.
 * Iceman / Bobby Drake
 * Voice Actor/Actress: Greg Cipes
 * Biography: A mutant with the ability to generate and manipulate ice and cold.
 * Appearance: The same as in Avengers Unleashed.
 * Colossus / Piotr Rasputin
 * Voice Actor/Actress: Matthew Mercer
 * Biography: A Russian X-Man with the mutant ability to transform his entire body into organic steel. He is a long time ally to Black Widow, who entrusted him to look after her daughter Katrina until the day she was ready.
 * Appearance: The same as in Avengers Unleashed.
 * Shadowcat / Katherine "Kitty" Pryde
 * Voice Actor/Actress: Hynden Walch
 * Biography: Mary Jane's younger cousin, one of Peter Parker's friends and a student and the hall monitor of Xavier's School for Gifted Youngsters, Kitty is a young mutant with the abilities to phase through matter and walk through solid objects (she can also fuse with and hide within the shadows of other living beings and subjects with this power) and shape-shift into a humanoid Lynx with increased strength and speed and communicate with felines (both domestic and wild cats).
 * Appearance: The same of her counterpart from Ultimate Marvel: Earth-2, and animated after the characters in Avengers: EMH!.
 * Beast / Dr. Hank McCoy
 * Voice Actor/Actress: Travis Willingham
 * Biography: A mutant with leonine attributes, prehensile feet and superhuman physical abilities. Hank acts as a teacher in Xavier's school and he builds inventions for troubled students and is the builder of the X-Jet. He is also a teacher in Baxter Institute.
 * Appearance: The same of his counterpart from Ultimate Marvel: Earth-2, and animated after the characters in Avengers: EMH!.

Masters of the Mystic Arts
Highly trained sorcerers who are committed to protecting the Earth from mystical threats.


 * Doctor Stephen Strange
 * Voice Actor/Actress: Marc Worden
 * Biography: A former neurosurgeon who, after a horrific car accident which led him to a journey of healing, discovered the hidden world of magic and alternate dimensions, and became a Master of the Mystic Arts, by which he earned the title of Sorcerer Supreme after defeating Dormammu.
 * Appearance: Based on Benedict Cumberbatch's character in the Marvel Cinematic Universe.
 * Wanda Maximoff
 * Voice Actor/Actress: Kate Higgins
 * Biography: A young Sokovian who, following an Hydra experiment with the Mind Stone and the Bloodgem, developed the abilities to harness magic and engage in hypnosis and telekinesis. After having a series of traumatic psychic attacks, Wanda was found by Doctor Strange, who trained her to be a Master of the Mystic Arts. Unlike most Marvel-related media, Wanda is not addressed to by the alias of Scarlet Witch, as she keeps demanding others not to give her any superhero code-names and just call her by her real name.
 * Appearance: Visually based on Elizabeth Olsen's character in the MCU (retaining her long straight brown hair and green eyes). Her Mystic Arts suit is a fully red outfit consisting of an red one-piece leotard, a pair of long boots and gloves, a tiara with a rose in it and a heart-shaped ruby in her forehead.
 * Wong
 * Voice Actor/Actress: Jim Meskimen
 * Biography: One of the Masters of the Mystic Arts, tasked with protecting some of Kamar-Taj's most valuable relics and books.
 * Appearance: Based on Benedict Wong's character in the MCU.
 * Cassandra Web
 * Voice Actor/Actress: Erica Luttrell
 * Biography: One of the Masters of the Mystic Arts, tasked with watching over parallel universes and dimensions through a mystic wall known as the Web of Reality.
 * Appearance: An older variant of her appearance in Ultimate Spider-Man vs. the Sinister 6.

Inhuman Royal Family
A group composed of Inhumans who are the main residents and leaders of the people of Attilan. They are close allies to Earth's superheroes against common threats in the galaxy.


 * Black Bolt
 * Voice Actor/Actress: Roger Craig Smith
 * Biography: The Head of the Inhuman Royal Family who is the King of Attilan, whose voice can cause destruction with the slightest whisper, and is a mentor to the young Inhumans on Earth. While he cannot speak with his mouth, he still speaks with humans and Inhumans through Telepathy.
 * Appearance: The same as in Avengers Unleashed.
 * Medusa
 * Voice Actor/Actress: Erica Lindbeck
 * Biography: Crystal's older sister, Black Bolt's wife and Queen of Attilan, who has the ability to control and move her hair and has a telepathic link with Black Bolt.
 * Appearance: The same as in Avengers Unleashed, but with the costume of Serinda Swan's character in the Inhumans live-action series.
 * Luna
 * Voice Actor/Actress: Jessica DiCicco
 * Biography: The 11-year-old daughter of Black Bolt and Medusa, Crystal's niece, a princess of Attilan and the youngest member of the Inhuman Royal Family, who has the abilities to fly and let out sonic wave blasts from her voice at will. She also shares her mother's ability to control and move her hair.
 * Appearance: Visually a long blond haired blue eyed girl with a cyan star tattoo around her right eye. She sports a barefoot white one piece leotard with the logo of Attilan in her chest place.
 * Karnak
 * Voice Actor/Actress: Robin Atkin Downes
 * Biography: Black Bolt's cousin and closest adviser, who can "see the fault in all things", avoiding errors, and acts as the Royal Family's strategist and philosopher.
 * Appearance: The same as in Avengers Unleashed.
 * Gorgon
 * Voice Actor/Actress: Kevin Michael Richardson
 * Biography: Black Bolt's cousin and leader of Attilan's Royal Guard, who can generate seismic waves with his cattle-like hooves.
 * Appearance: The same as in Avengers Unleashed.
 * Lockjaw
 * Voice Actor/Actress: N/A
 * Biography: Crystal's 2,000-pound (910 kg) canine companion and an Inhuman dog with the teleportation power (as well as other abilities) who serves the Inhuman Royal Family as their escort and as a loyal protector.
 * Appearance: The same as in Avengers Unleashed.

S.H.I.E.L.D. (Strategic Homeland Intervention, Enforcement and Logistics Division)
A espionage, special law-enforcement, and counter-terrorism agency allied to the Avengers which often deals with paranormal and superhuman threats.


 * Nick Fury
 * Voice Actor/Actress: Terrence C. Carson
 * Biography: The director of S.H.I.E.L.D. who originally recruited the Avengers and continues to be a mentor and benefactor for the team.
 * Appearance: Based on Samuel L. Jackson's character in the MCU.
 * Maria Hill
 * Voice Actor/Actress: Susan Eisenberg
 * Biography: Fury's second-in-command and a high ranking S.H.I.E.L.D. commander. She also acts as a supervisor to the New Champions.
 * Appearance: Based on Cobie Smulders' character in the MCU.
 * Phil Coulson
 * Voice Actor/Actress: Clark Gregg
 * Biography: An agent within S.H.I.E.L.D. who oversees many of the division's field operations. He is a close ally to the Avengers, a supervisor of the New Champions and long-time fan of Captain America.
 * Appearance: Based on Clark Gregg's character in the MCU.
 * Dr. Henry "Hank" Pym
 * Voice Actor/Actress: Jim Meskimen
 * Biography: The maternal grandfather of Gwen Stacy and Cassie Lang and Scott Lang's father-in-law, he is a S.H.I.E.L.D. entomologist, and physicist who became the original Ant-Man after discovering the subatomic particles which make the transformation possible. He is also a teacher in Baxter Institute.
 * Appearance: Based on Michael Douglas' character in the MCU.
 * Jocasta
 * Voice Actor/Actress: Tara Strong
 * Biography: Dr. Pym's A.I. assistant.
 * Appearance: The same as in The Avengers: EMH!, but with violet eyes.
 * Prowler / Jefferson Davis
 * Voice Actor/Actress: Khary Payton
 * Biography: Miles' father, and a NYPD officer working for S.H.I.E.L.D. as an armored spy. He is said to have been chosen to replace Clint Barton (who had resigned to operate as Ronin) due to his willpower and high talents.
 * Appearance: Visually based on Denzel Washington. His Prowler suit is based on the one seen in the 2007 video game Spider-Man: Friend or Foe.
 * War Machine / James "Rhodey" Rhodes
 * Voice Actor/Actress: Ogie Banks
 * Biography: An officer in S.H.I.E.L.D. and the U.S. Air Force who is Tony Stark's close personal friend. He operates his own prototype of the Iron Man suit, the War Machine armor. He is also a reserve member of the Avengers and occasional trainer of the New Champions.
 * Appearance: The same as in Avengers: EMH!. His armor has the same details as the one seen in Avengers: Infinity War.
 * Dum Dum Dungan
 * Voice Actor/Actress: Fred Tatasciore
 * Biography: An officer of S.H.I.E.L.D. who is one of the most experienced members of Fury's patrol, known for his marksmanship with rifles and impressive physique.
 * Appearance: Based on on Neal McDonough's character in Captain America: The First Avenger, with modern S.H.I.E.L.D. attire.

Minor Characters

 * Uncle Ben
 * Voice Actor/Actress: Alan Tudyk
 * Biography: Peter's deceased uncle, who once taught him that "With Great Power, there will come Great Responsibilities" prior his death during the Oscorp riot, which Peter holds Norman Osborn responsible for.
 * Appearance: Visually a brunette with hazel eyes.
 * Howard Stark
 * Voice Actor/Actress: Mick Wingert
 * Biography: Tony Stark's deceased father, Luke's grandfather and the founder of Stark Industries who played a role in the WWII Super Soldier project which created Captain America and created Rogers' Vibranium shield. He appears in a flashback of Captain America's origins and in statues and portraits in present day scenes.
 * Appearance: The same as in The Avengers: EMH!.
 * Clayton Quill
 * Voice Actor/Actress: Alan Tudyk
 * Biography: Nathan's deceased father, he was formerly one of Norman Osborn's bodyguards who lost his life during the Oscorp riot of one year ago. His death led to his son Nathan share Peter Parker's mutual hatred and distrust on Osborn. Prior his death, Clayton had inspired his son Nathan into becoming an astronaut and scientific genius after taking him for a trip in NASA.
 * Appearance: Visually an older version of Nathan himself, with brown eyes.
 * Robin Chapel
 * Voice Actor/Actress: Marisha Ray
 * Biography: The director of Damage Control, a construction company owned by S.H.I.E.L.D. which specializes in repairing the property damage caused by conflicts between superheroes and super-villains. She appears in occasional episodes of the show along with her crew, working with superheroes in repairing the damage caused in certain places.
 * Appearance: The same as in the comics, and animated after the females in The Avengers: EMH!.
 * The Ancient Ones
 * Voice Actor/Actress: Fred Tatasciore (Male Member #1), Misty Lee (Female Member) and Dave Fennoy (Male Member #2)
 * Biography: A trio of ancient sorcerers and the first Masters of the Mystic Arts. Though they have died long ago, they still appear as spirits in the Astral Plane, occasionally giving advice to the current Masters of the Mystic Arts and other metahumans (including superheroes) about certain circumstances they are needed.
 * Appearance: One male Ancient One is based on the original character from Earth-616. The female Ancient One is based on Tilda Swinton's character in the MCU. And the second male Ancient One is a bald version of Brother Voodoo in Marvel: Future Fight.
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 * Eugene "Flash" Thompson
 * Voice Actor/Actress: Will Friedle
 * Biography: A 18-year-old repugnant and selfish high school jock who used to bully Peter. He was also Sally Avril's first boyfriend until she broke up with him after she caught him getting kissed in his lips by a cheerleader celebrating the school's football team's last year victory in a championship. He first appears in the two first episodes of Spider-Man's Arc, on which he antagonizes Peter as a "little nobody" and disbelieves the claims that Peter is a friend of Spider-Man, whom Thompson ironically idolizes. He also did not share the Osborns' concerns over Peter dropping out of the school to join the Baxter Institute. Initially considered to be the most popular jock in Midtown High, Thompson's popularity eventually begun to collapse after he and J. Jonah Jameson inadvertently interrupted Annabelle Brady's interview with Peter about the Baxter Institute, causing Anna to leave Midtown High and Thompson to get suspended from the upcoming football championship. Taking his anger on Jameson over the incident, Thompson's situation eventually gets even worse when the Living Brain swaps Thompson's mind and body with Jameson's, causing Thompson to incriminate Jameson by beating up the Daily Bugle employees, threatening to throw them out of the building unless they write news about "Midtown High being superior to Baxter Institute" and trashing their work places until Mary Jane Watson knocked him unconscious and the body swap was reversed. Despite being his former self again, Thompson was eventually expelled from Midtown High after Jameson (in Thompson's body) incriminated him by getting in a fight against the jocks dressed as Spider-Man and insulting the teachers and cheerleaders. He now does community service, while also ashamed of showing himself to Peter and his friends, whom he is afraid that they might mock him for his embarrassing failure.
 * Appearance: Visually based on his Earth-12041 counterpart.
 * Ashley Kafka
 * Voice Actor/Actress: Marisha Ray
 * Biography: A Midtown High School student, and a top class reporter who was Anna Brady's (former) superior. Despite being a dedicated student, she is shown to be rather overbearing and bossy towards her classmates. Though she had a dislike for Peter Parker due to his occasional misfortunes and failures in Midtown High (and also reprimanding him for not being like Flash Thompson) and infamously mocking that "his friends are outside Midtown High", Kafka (very much like the Osborns) did not approve Peter's decision to drop out of the school to enroll at Baxter Institute, although she speechlessly relented after Peter loudly accused Osborn for certain incidents (such as the Oscorp riot in the day when Uncle Ben died) in front of many. Though she also shares the same positive opinions others have about superheroes, including Spider-Man, Kafka is shown to be still resentful of Peter and his friends, whom she blames for the Midtown High students' recent misfortunes, and appears not to believe Peter's claims that Osborn is to blame for what happened until his true colors and evil nature are exposed to New York. In the last episodes of Spider-Man's arc, it is mentioned that Kafka did not enroll at any other school after she developed a severe PTSD and depression, despondent over how wrong she was about herself and the people she hated. She is also even shown in a cell at a mental hospital wearing a straight-jacket sobbing uncontrollably in the ground.
 * Appearance: A short haired brunette with hazel eyes.
 * Hector "Hercules" Quill
 * Voice Actor/Actress: James Arnold Taylor
 * Biography: Nathan's 18-year-old estranged older brother and a Midtown High jock who is close to Flash Thompson. He has a distant relationship with his family, preferring to live in a apartment he earned for himself in a building near Midtown High rather than live with his siblings, who in turn view him as a repugnant and selfish bully just like Flash. Nathan strongly dislikes Hector for his willingness to cope with their father's death so easily by enrolling at Midtown High, which Norman Osborn became benefactor of. Later, after Thompson was expelled from school (as a result of the body swap between him and J. Jonah Jameson), Hector took over as captain of the school's football team.
 * Appearance: Visually based on the character Steve featured in flashbacks of Marvel's Spider-Man episode "A Troubled Mind".

Main Antagonists

 * Thanos
 * Voice Actor/Actress: Michael-Leon Wooley
 * Biography: An intergalactic despot from Titan with a goal to destroy half of every population he invades to "re-balance the universe". He is the main antagonist of the Infinity Arc and the entire Season 1.
 * Appearance: Based on Josh Brolin's character in the Marvel Cinematic Universe. His armor resembles the one worn in Avengers: Endgame.
 * Green Goblin / Norman Osborn
 * Voice Actor/Actress: Jeffrey Combs
 * Biography: A scientist, engineer, billionaire, founder and owner of Oscorp and the benefactor of Midtown High School. Despite worshiped by his son Harry and other students, he is otherwise hated by Peter Parker, who blames him for the incident in Oscorp which led to Uncle Ben's death. From the episode Living Brainstorm, Osborn's brain (and later his mind and body) is possessed by the spirit of the Goblin, slowing transforming him into a sadistic psychopath. The transformation is completed once Goblin has Osborn ingest a serum which hideously mutates his appearance, purging Norman Osborn's persona completely and letting the Goblin in full control.
 * Appearance: Visually based on his appearance in Marvel's Spider-Man 2017 TV series. As Green Goblin, he is visually a human-sized variant of his appearance in Ultimate Spider-Man and sports an armor based on the suit worn by Harry Osborn in Marc Webb's The Amazing Spider-Man 2.
 * The Goblin / Living Brain
 * Voice Actor/Actress: Jeffrey Combs
 * Biography: An sadistic Dark Elf whose consciousness was absorbed by the Living Brain after a failed assault on Earth. Taking control of the Living Brain, the Goblin was soon accidentally reactivated by two A.I.M. agents and went for a rampage before he was defeated by Spider-Man, Mister Fantastic and Edith, but not before the Goblin transferred his consciousness into some bits of Norman Osborn's brain, slowly taking over his body.
 * Appearance: The Goblin is visually a human-sized variant of his appearance in Ultimate Spider-Man, but with a grey skin. His Living Brain body shares similar details of the one seen in Marvel's Spider-Man.
 * Ronan the Accuser
 * Voice Actor/Actress: Jonathan Adams
 * Biography: A high-ranking Kree official who is fanatical about their culture and practices, and is on his own campaign of genocide of other alien races, consequently coming in conflict with heroes like the Avengers and the Guardians of the Galaxy. He also has some intense rivalry with Thanos.
 * Appearance: Based on Lee Pace's character in the Marvel Cinematic Universe.
 * The Beyonder
 * Voice Actor/Actress: John DiMaggio
 * Biography: An interdimensional God-like entity who longs to destroy all Earths.
 * Appearance: Based on his looks in Avengers: Secret Wars.
 * The Serpent
 * Voice Actor/Actress: Robin Atkin Downes
 * Biography: The brother of Odin, uncle of Thor, and the Norse God of Fear.
 * Appearance: The same as in the comics.

The Black Order
A group composed of supervillains who serve Thanos.


 * Amora the Enchantress
 * Voice Actor/Actress: April Stewart
 * Biography: A seductive Asgardian sorceress who has a deadly obsession for Thor. She is Thanos' adopted daughter and the leader for his new Black Order.
 * Appearance: The same as in Avengers Unleashed.
 * Skurge the Executioner
 * Voice Actor/Actress: J. B. Blanc
 * Biography: The Enchantress' faithful servant and bodyguard and a hulking Asgardian viking armed with his large, enchanted, double-bladed battle axe (which allows him a number of abilities including cutting rifts into other dimensions and control over fire and ice which he can project at his enemies) and a pair of large guns. As he is loyal to the Enchantress, he is also a servant of Thanos.
 * Appearance: The same as in Avengers Unleashed.
 * Ultron
 * Voice Actor/Actress: Jim Meskimen
 * Biography: An Artificial Intelligence android created by Thanos to be his lead scientist (a role similar to Decepticon Shockwave in Transformers: Prime).
 * Appearance: The same as in The Avengers: Earth's Mightiest Heroes!.
 * Mysterio / Quentin Beck
 * Voice Actor/Actress: Fred Tatasciore
 * Biography: A former employee of Oscorp who was fired by his executives because of his unstable nature, he is a master of illusions and trickery, the creator of the Elementals and a member of Thanos' Black Order. He was one of the first villains fought by Peter Parker in his first six months as Spider-Man.
 * Appearance: The same as in Ultimate Marvel: Earth-2.
 * Kingpin / Wilson Fisk
 * Voice Actor/Actress: Dave Fennoy
 * Biography: A maniacal crimelord of New York and a member of Thanos' Black Order. He secretly longs to take over Thanos' place as the Black Order's master (a role similar to Starscream in the Transformers franchise).
 * Appearance: Based on his looks in Spider-Man: Into the Spider-Verse, but a few inches shorter.
 * Purple Man / Zebdiah Kilgrave
 * Voice Actor/Actress: James Arnold Taylor
 * Biography: A member of Thanos's Black Order who has telekinetic and telepathic abilities (similar to those of Ebony Maw in the MCU).
 * Appearance: The same as in The Avengers: EMH!, but with Ebony Maw's armor and outfit from Avengers: Infinity War and Avengers: Endgame.
 * Morgan Le Fey
 * Voice Actor/Actress: Nika Futterman
 * Biography: A powerful sorceress from King Arthur's legend, and one of Thanos' enforcers. She is also somewhat jealous of Amora the Enchantress.
 * Appearance: Based on her appearance in Ultimate Spider-Man.
 * Abomination / Emil Blonsky
 * Voice Actor/Actress: Steve Blum
 * Biography: One of Hulk's closest foes and a former officer loaned to General Ross who, lusting for the Hulk's power, was injected with various serums which transformed him into a near-skeletal humanoid monster as powerful as the Hulk himself, but also drove him insane. After being banished from Earth, Blonsky became a member of the new Black Order, serving as Thanos' "beast machine super-soldier".
 * Appearance: Based on Tim Roth's character in The Incredible Hulk.

Shadow Council
A secret cabal of supervillains (consisting of Doctor Octopus, Yellowjacket, Killmonger, Malekith the Accursed and Tiger Shark and led by Madame Masque) with the aim of global conquest by any means necessary.


 * Madame Masque / Whitney Frost
 * Voice Actor/Actress: Courtenay Taylor
 * Biography: A former Hydra scientist who became Madame Masque after discovering a Kree ship with help from some Hydra agents and putting on its control mask to save it from sinking. The mask is advanced technology which gives her the power to connect and manipulate any machines, powered by the ship itself. But due to the mask being unstable for humans (and other non-Kree lifeforms), it drove her mad with power, leading her to desire to change the world by enforcing her will over it. She is Liz Danvers Rogers' former school teacher and currently the leader of the Shadow Council.
 * Appearance: Based on her looks in Avengers: Black Panther's Quest.
 * Doctor "Doc Ock" Octopus / Master Planner / Otto Octavius
 * Voice Actor/Actress: C. Thomas Howell
 * Biography: A former Oscorp scientist who worked to perfect prosthetic limb technology and became a super-criminal called the Master Planner after four mechanical appendages were permanently attached to his back during an accident in his lab (it turned out to be an sabotage by Quentin Beck as an attempt to win Osborn's appreciation) which also killed his wife Rose, using an intra-cranial neural network to connect them to his nervous system. He was also once a brilliant, but neglectful science teacher in Midtown High School until he was fired and arrested after being exposed to public eyes by Spider-Man and his LMD (disguised as Peter Parker) for his crimes. After being broken out of his cell by Madame Masque and becoming a member of her Shadow Council, Octavius now operates in the alias of Doctor Octopus while he still longs for revenge on Osborn for ruining his life.
 * Appearance: Visually based on his last appearance in Ultimate Spider-Man vs. the Sinister 6, and sporting the same attire as in the 2018 Spider-Man video game. Initially as the Master Planner, he wore a black-hooded, red-eyed mask with a robotic face. As Doctor Octopus, he wears his goggles from the comics.
 * Yellowjacket / Darren Cross
 * Voice Actor/Actress: Dwight Schultz
 * Biography: The owner of Cross Technological Enterprises and Pym's sworn business rival, he militarizes a similar version of the Ant-Man technology to create the Yellowjacket suit.
 * Appearance: The same as in Avengers Unleashed.
 * Killmonger / N'Jadaka
 * Voice Actor/Actress: Keston John
 * Biography: A Wakandan exile and former U.S. black-ops soldier who seeks to overthrow T'Challa, with his own opinion on how Wakanda should be ruled. He is armed with his own version of T'Challa's energy absorbing suit which, reminiscent of his comic book counterpart, has pronounced fangs and glows gold when being used.
 * Appearance: Based on Michael B. Jordan's character in Black Panther.
 * Malekith the Accursed
 * Voice Actor/Actress: Steve Blum
 * Biography: One of Thor's old foes and the ruler of the Dark Elves of Svartalfheim.
 * Appearance: Based on Christopher Eccleston's character in Thor: The Dark World.
 * Tiger Shark
 * Voice Actor/Actress: Fred Tatasciore
 * Biography: An Atlantean exile and a vicious humanoid shark who rebelled against Atlantis in protest of the peace treaty between his homeland and the surface world. He is a reluctant member of the Shadow Council.
 * Appearance: The same as in Avengers: Black Panther's Quest, and animated after the males in Avengers: EMH!.
 * Rhino / Bonesaw McGee
 * Appearance: J. B. Blanc (similar to Bane in Batman: Arkham Origins)
 * Biography: A former professional wrestler who was subjected to be part of Oscorp's Super-Soldier experiments until he was transformed into a mindless humanoid rhinoceros. He was then brainwashed by Madame Masque as her Shadow Council's "beast machine super soldier".
 * Appearance: Rhino is visually based on Aleksei Sytsevich's version in Marvel's Spider-Man. Bonesaw McGee is based on Randy Savage's character in Sam Raimi's 2002 Spider-Man film.

Hydra
A terrorist Nazi group formed by the Red Skull to rule over humanity by any means.


 * Red Skull / Johann Schmidt
 * Voice Actor/Actress: Liam O'Brien
 * Biography: The head and creator of Hydra and Captain America's arch-nemesis.
 * Appearance: Based on his appearance in Avengers: EMH!.
 * Sinthea Schmidt
 * Voice Actor/Actress: April Stewart
 * Biography: A German orphan who was raised by Skull as his own daughter and grew up becoming his personal agent.
 * Appearance: The same as in the comics.
 * Crossbones / Brock Rumlow
 * Voice Actor/Actress: Fred Tatasciore
 * Biography: An high-ranking agent and assassin of Hydra armed with a nearly indestructible combat armor and a pair of strength-enhancing shockwave gauntlets.
 * Appearance: Based on Frank Grillo's character in Captain America: Civil War.
 * Madame Hydra / Viper / Ophelia Sarkissian
 * Voice Actor/Actress: Erica Luttrell
 * Biography: A high-ranking general of Hydra who, after injecting herself with an stolen Super Soldier serum combined with Dr. Curt Connors' Lizard formula, became able to shape-shift into a monstrous humanoid snake with increased strength, a large snake tail replacing her right arm and the ability to spit acid venom. She is a formidable foe to the Avengers and Tigra's arch-nemesis. Like Sally Avril in her Snow Leopard form, she wears no clothes in her transformation.
 * Appearance: The same as in Ultimate Marvel: Earth-2.
 * The Jackal / Raymond Warren
 * Voice Actor/Actress: John DiMaggio
 * Biography: The principal of Midtown High who, due to exposure to his chemical serums, can turn into an animalistic, green-furred metahuman called "The Jackal". Similar to Dr. Jekyll/Mr. Hyde, the progress also divided Warren's personality in two: as a regular-minded human when in human form, and as a insane criminal trying to steal technology for Hydra when in the Jackal's form.
 * Appearance: Visually the same as in Marvel's Spider-Man, and animated after them males in The Avengers: EMH!.
 * Crimson Widow / Yelena Belova
 * Voice Actor/Actress: Julie Nathanson
 * Biography: Baron Strucker's latest graduated student in the Red Room program, and the second assassin to earn the name "Black Widow". Though she is loyal and devoted to the Red Skull, Belova has a rather intense rivalry with Jackal, whom she is always distrustful of.
 * Appearance: The same as in Avengers: Black Panther's Quest, and animated after them females in The Avengers: EMH!.
 * Arnim Zola
 * Voice Actor/Actress: Armin Shimerman
 * Biography: A Nazi biochemist during World War II who survived into the modern age by transferring his conscious mind into the body of a sophisticated robot which protected it by storing it in its chest and displaying a digital image of Zola's face on its chest plate.
 * Appearance: The same as in Avengers Unleashed.

Kree Empire
A scientifically and technologically advanced militaristic race of blue-skinned humanoids from the planet Hala.
 * Supreme Intelligence
 * Voice Actor/Actress: Kevin Michael Richardson
 * Biography: The center of the collective minds of the greatest Kree of Hala who is the supreme ruler of the Kree.
 * Appearance: The same as in Avengers: EMH!.
 * Minn-Erva
 * Voice Actor/Actress: Nika Futterman
 * Biography: A Kree scientist and spy loyal to Ronan.
 * Appearance: Based on Gemma Chan's character in Captain Marvel.
 * Korath the Pursuer
 * Voice Actor/Actress: Dave Fennoy
 * Biography: A Kree ally of Ronan who is a feared intergalactic hunter.
 * Appearance: Modeled after Djimon Houson's character in the Marvel Cinematic Universe, but with blue skin.

The Worthy
Corrupted heroes, villains and anti-heroes from parallel earths possessed by seven hammers dropped down to Earth being loyal to the Serpent.
 * The Maker / Ultimate Reed Richards
 * Voice Actor/Actress: Robin Atkin Downes
 * Biography: Mr. Fantastic's evil counterpart from Earth-1610.
 * Appearance: The same as in the Ultimate Comics.

Individual Villains

 * Doctor Doom / Victor Von Doom
 * Voice Actor/Actress: Maurice LaMarche
 * Biography: The Fantastic Four's archenemy, and the tyrannical ruler of Latveria.
 * Appearance: Based on Julian McMahon's character in the 2005 Fantastic Four film and its sequel Rise of the Silver Surfer.
 * Maximus Boltagon
 * Voice Actor/Actress: Matthew Mercer
 * Biography: Black Bolt's treacherous brother, who has a strong devotion to the people of Attilan and a desire to be king himself. Maximus lost the Inhuman gene when going through the Terrigenesis process, which led to the character being looked down on by other Inhumans.
 * Appearance: The same as in Avengers Assemble and Ultimate Spider-Man, but with the animation of The Avengers: EMH!.
 * Hobgoblin / Harry Osborn
 * Voice Actor/Actress: Sam Riegel
 * Biography: Norman Osborn's dedicated son and the class president in Midtown High School, he secretly operates as the Hobgoblin, equipped with an armored suit created by Oscorp which includes a glider, pumpkin bombs and a heat sword. Contrary to most incarnations where Peter and Harry are best friends, Peter is shown to have more distant relationship with Harry in the show, as Peter blames Harry's father for Uncle Ben's death and Harry (much like his father) does not approve Peter's enrollment at Baxter Institute.
 * Appearance: Visually a teenage variant of his father with hazel-eyes and red-hair. His Hobgoblin suit is based on the one seen in Marvel's Spider-Man.
 * Sheath
 * Voice Actor/Actress: Erica Luttrell
 * Biography: A street delinquent and a Inhuman criminal with metal shards protruding from her body.
 * Appearance: The same as in the Marvel Rising franchise.
 * Loki / Loren Williams
 * Voice Actor/Actress: Greg Ellis
 * Biography: A mentally ill Oscorp executive who believes himself as the reincarnation of Loki, Thor's deceased adopted brother and trickster of the Asgardians (who perished during the destruction of Asgard), based on the Norse mythological deity of the same name. He wields a technologic scepter which enables him to manipulate technology and control others' minds.
 * Note: This version shares principles similar to those of Maxie Zeus in DC Comics.
 * Appearance: Based on Tom Hiddleston's character in the MCU, but sporting a business suit (based on the attire of the Joker in DC Comics) with green cape and golden horned helmet.
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 * J. Jonah Jameson
 * Voice Actor/Actress: John DiMaggio
 * Biography: An arrogant journal editor who wrongly criticizes Spider-Man and views him as a menace, and is greedy for Peter Parker's proposal of working for the Daily Bugle to earn the evidence of Spider-Man's identity. He first appears in "Living Brainstorm", on which he interrupts Annabelle Brady's interview with Peter about Baxter Institute greedily demanding him answers of Spider-Man's identity, consequently getting in a fight with Flash Thompson and causing Peter to dismiss them all. After an angered Anna drops out of Midtown High accusing Jameson and Thompson for the incident, Jameson is given a restraining order to keep him away from Peter and any Baxter Institute student. Later after another hostile encounter with Thompson, Jameson witnesses Spider-Man fighting the Living Brain until he and Thompson are accidentally hit by the robot's Neuro-beams. At first, the beam has no apparent effect until it transfers Jameson's mind with Thompson's body, causing Jameson to incriminate Thompson by getting in a fight against the jocks dressed as Spider-Man and insulting the teachers and cheerleaders until Sally Avril knocked him unconscious and the body swap was reversed. Despite being his former self again, Jameson eventually gets fired from Daily Bugle and arrested after Thompson (in Jameson's body) incriminated him by beating up the Daily Bugle employees and trashing their work places.
 * Appearance: The same as in The Avengers: EMH!, but with hazel eyes.

Anti-Heroes

 * Venom / Eddie Brock
 * Voice Actor/Actress: Crispin Freeman (as Eddie Brock) and Kevin Michael Richardson (as Venom)
 * Biography: A disgraced, former Daily Globe journalist who became the current host of an alien Symbiote, which grants him superhuman abilities.
 * Appearance: Based on Tom Hardy's character in the 2018 film Venom.
 * Michael Morbius, the Living Vampire
 * Voice Actor/Actress: Troy Baker
 * Biography: A scientist suffering from a rare blood disease who attempted to cure himself with DNA from vampire bats, but instead became afflicted with a new form of vampirism, giving him superhuman strength, speed, and durability, flight, echolocation, hypnotism, accelerated healing factor and life-force absorption.
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Stan Lee's Cameos
As in most of current Marvel movies and TV shows, Stan Lee also makes posthumous cameo appearances in several episodes of Marvel: All New, All Different Chronicles. Some cameos are silent and inaudible. Others have dialogues done via archive footage from previous cameos in TV shows, films and video games.

Spider-Man's Arc

 * “A Better Genius” - Lee makes appears at the end of the episode as the concierge in Baxter Institute who welcomes Peter to the new school.
 * “Living Brainstorm” - Lee accompanies Annabelle "Anna" Brady after she leaves Midtown High to join the Bilderberg Academy while comforting her over her failed interview with Peter Parker in Roxxon. Lee later gives a disappointed look at Flash Thompson, as he knows Thompson and J. Jonah Jameson had inadvertently disrupted Anna's interview by mocking Peter and greedily demanding answers about Spider-Man's identity respectively.
 * “Feline Power” - In the end of the episode, when Peter Parker and Luke Potts Stark comment about Sally Avril and her metahuman condition after she left to Pegasus Z, Lee approaches the two and says: "Hey. Don't give up on her. Either of you.", to which Peter replies "Certainly not, sir.", and Luke says: "Never in this life.". Lee's lines in the episode are taken from the 2018 film Venom.
 * “Castle of Illusions” - In the beginning of the episode, Lee is shown fixing a machine in Baxter Institute before Michelle Jones tests it. When the machine works well, Lee asks: "Did it work?". This quote is taken from the 2011 film Thor.
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Avengers' Arc

 * “Our National Treasure” - Lee can be seen during the prologue, attending to Steve Rogers and Carol Danvers' wedding.
 * “The Tiger and the Hawk” - Lee can be seen as a pedestrian reading a newspaper while the Avengers fighting the Sakaarians in New York. Oblivious of the fight, Lee is shown calmly standing still and reading the newspaper before leaving while the Hulk saves him from getting hit by a Sakaarian gunship.
 * “Inhuman Bloodlines” - During Crystal's first visit to the Avengers Tower, numerous portraits of the Avengers are shown in the walls. Stan Lee is shown in one of the portraits which was taken with Tony Stark and Natasha Romanoff.

Guardians of the Galaxy's Arc

 * “Rocket Man” -
 * “Guardians at the Gate” -
 * “The Flerken Sleeps Tonight” -