The Binding of Isaac: The Series

 The Binding of Issac: The Series  is an Animation Adult Amecrican Adventure Fantasy Sitcom Drama television series created and directed by Jonathan Walpe and Kylan Williams with serving as writers for the show with Edmund McMillen and Florian Himsl serving as executive producers.The first part of season 1 aired worldwide on February 7, 2024 with 13 episodes, with the second part airing on April 8, 2024 with an additional 13 episodes. The second season premiered on October 5, 2024 with 13 episodes with additional 13 episodes released on December 21, 2024. The third season premiered on September 13, 2023 with 13 episodes with additional 13 episodes released on December 15, 2024. The 4th and final season premiered on March 10, 2025 with 15 episodes. Jonathan Walpe announced that the series would end with its 4th season, stating that it was "100% his choice" and that "the show is not cancelled, it is ending" and simply reaching its natural conclusion. The series ended on December 29, 2024, with the hour-long finale, Ultimate Show.

The Binding of Issac: The Series received critical acclaim, with praise for the writing, animation, voice acting, characters, humor, and action sequences, with particular praise for fidelity to the game series.

Several spin-off series involving Azazel, Lazarus, Eden and The Lost.