Spider-Man: What's Up Danger?

 is an American animated action-adventure superhero television series, being based on ', itself based on ' by Marvel Comics. It is produced by Marvel Animation and Disney Television Animation and it airs on Disney Channel since October 12th, 2020.

Synopsis
Miles Morales is your average teenager, until he gets bitten by a radioactive spider as he becomes the newest Spider-Man in the now deceased Peter Parker's image.

Main

 * Miles Morales/Spider-Man (voiced by Zeno Robinson) - an African American-Hispanic teenager who gets bitten by a radioactive spider and becomes his own superhero.

Supporting

 * Jefferson Davis (voiced by Gary Anthony Williams) - Miles' father who is a police officer and wants to make sure his son is safe.
 * Rio Morales (voiced by Alanna Ubach) - Miles' mother who is an EMT and equally cares for her son's safety and cares about her husband as well.
 * Ganke Lee (voiced by Dante Basco) - Miles' geeky best friend who figures out his secret identity as the Spider-Man and aids him in his heroic crusade.
 * Lana Baumgartner/Bombshell (II) (voiced by Liliana Mumy) - the daughter of the first Bombshell who was originally a member of the gang called the Bombshells until she redeems herself and starts working as a minor heroine, having a crush on Miles.
 * J. Jonah Jameson (voiced by Mark Hamill) - a former detractor of Spider-Man who is now going through a crisis as he somewhat supports the new Spider-Man yet shows a sign of concern for New York's safety, trying to make sure Spider-Man doesn't screw up.

Antagonists

 * Aaron Davis/Prowler (voiced by Khary Payton) - Miles' uncle who is a masked criminal named the Prowler and becomes obsessed with the Spider-Man.
 * Lee Price/Venom (voiced by TBD) - a seemingly pathetic thug who bonds with the now hostless Venom as he shows a near sadistic love of violence.
 * Maximus Gargan/Scorpion (voiced by John DiMaggio) - a thug who wields a chain with a "stinger" and calls himself the brand new Scorpion.
 * The Sinister Seven, consisting of:
 * Eduardo Lobo (voiced by Danny Trejo) - a Hispanic mob boss who can turn himself into a werewolf and uses it to commit crimes.
 * Jake Nash/Shade (voiced by Matthew Mercer) - a convict who turned himself into a living darkness out to kidnap people to return to his normal form.
 * Kateri Deserti/Coldheart (voiced by Grey Griffin) - a former military soldier who after witnessing her son die in the battle that killed Spider-Man, heads after the new Spider-Man, claiming his death will avenge her son.
 * Klaus Schmidt/Mad Bomber (voiced by Jason Spisak) - a mad criminal who stole a bunch of bombs and plans to blow up New York for his twisted idea of fun.
 * Leona Michaels/Tarantula Hawk (voiced by Ashley Johnson) - a teenage girl obsessed with Spider-Man as she steals an experimental suit just to impress him but ends up getting rejected by him and now wants to prove that she is better and more powerful than him.
 * Lori Baumgartner/Bombshell (I) (voiced by Tara Strong) - Lana's mother who is a professional criminal and after her daughter's defection to the good side, gets obsessed with getting her daughter back to her.
 * Clayton Cole/Clash (voiced by Josh Keaton) - an obsessive man who was the original Spider-Man's biggest fan, now blaming both J. Jonah Jameson and the new Spider-Man for the first Spider-Man's death and heads to kill them both.
 * Elias Wirham/Cardiac (voiced by DC Douglas) - a surgeon who has been transformed into a deadly threat capable of controlling heartbeats as he wants revenge on those who turned him into a beast.
 * Francine Frye/Electro (voiced by TBD) - a party animal teenager who gets into an accident, becoming the new Electro as she wants to turn New York into a never ending party without adults to shut her down.
 * Richard Deacon/Human Fly (voiced by TBD) - a normal scientist who is obsessed with flies as he willingly mutates himself into a fly-monster as he becomes an extremely deranged and feral beast.
 * Samantha Braxton/Slime (voiced by TBD) - a thug who worked for Eduardo Lobo who gets mutated into becoming made out of slime, making her immune to several attacks due to her slime-like composure.

Episodes
See List of episodes.

Trivia

 * The series mixes several lesser known Spider-Man villains with original villains.
 * Each episode has a title based on a song from various genres including rap, pop and musicals as well as titles based on movies, shows and video games.