Shyro the Dragon

Heroes

 * Ben Diskin as Shyro the Dragon, the titular character and the protagonist of the show. He is speedy, quick thinking, cheeky, carefree, clever, enthusiastic, but overall he is friendly deep down inside. Shyro's also somewhat of a lady's man, flirting with Princess Luna. He bears a strong resemblance to Shoutmon.
 * Bill Fagerbakke as CJ, Shyro's best friend and the deuteragonist of the show. He bears a strong resemblance to Ballistamon.

Allies

 * Kate Higgins as Princess Luna, Shyro's girlfriend, love interest, and sweetheart. She bears a strong resemblance to Lunamon.

The Technodrone Crew

 * Gary Chalk as The Spectralizer, the arch-villain of the show. He always, against his will, has to take orders from Crang. He is so eccentric, bumbling, rude, and quick-tempered villain who gets his revenge on Shyro and CJ. He bears a strong resemblance to an anime version of the Shredder.
 * Pat Fraley as Crang, an extremely intelligent, disembodied brain from Incubator Planet X1, who commands the Technodrone. He funds and helps plan most of Spectralizer's schemes. He bears a strong resemblance to Krang.
 * Cam Clarke as Dorsal, is one of Spectralizer's clumsy oafish henchmen. He is Rocksteady-esque anthromorphic shark in the show.
 * Rob Paulson and Barry Gordon as Muttface, is one of Spectralizer's clumsy oafish henchmen. He is Bebop-esque anthromorphic bulldog in the show.