Deadpool & She-Hulk

Deadpool & She-Hulk is an American comic book series published by Marvel comics starring the titular characters of the same name. The series is a comedy with a few dramatic elements and features the two characters due to their nature as breakers of the fourth wall.

Main

 * Wade Wilson/Deadpool - the mercenary who is known to never stop talking. Despite his jokey nature, it has been implied he has some form of depression, though it has never been stated outright.
 * Jennifer Walters/She-Hulk - a famous lawyer and the cousin of Bruce Banner. She is very light-hearted and has had many different lovers in the past.

Recurring

 * Bruce Banner/Hulk - Jennifer's cousin.
 * Nathan Summers/Cable - the son of Cyclops from the future who is an ally to Deadpool.
 * Lady Death - Death in the form of a sexy woman.
 * Louise Grant - formerly known as the Blonde Phantom, Louise is another character with the ability to break the fourth wall.
 * Richard "Rick" Jones - a friend of Bruce and Jennifer's who is jokingly referred to as "the ultimate side-kick".
 * Thaddeus "Thunderbolt" Ross - an army general who has a complicated relationship with superhumans.

Antagonists

 * Anthony “Tony” Masters/Taskmaster - an assassin who can copy people’s abilities.
 * Mary MacPherran/Titania - an incredibly powerful warrior and She-Hulk's self-proclaimed arch-nemesis.
 * Mad Cap - an insane man who has extremely powerful regeneration abilities.
 * Manfred Haller/Behemoth - a businessman in a robotic elephant suit.
 * T-Ray - the closest thing Deadpool has to an archenemy who claims he is the real Wade Wilson and his identity was stolen.
 * Florence Sharples/Abominatrix - a large unintelligent mutant who is a female counterpart of Abomination.
 * Evil Deadpool - a clumped up mass of Deadpool's lost body parts that has two right arms.