An Octopus is My Best Friend

, also known as Disney's , is an American animated television series created by Catherine Uhlman. It is being created by Walt Disney Television Animation and Disney Channel Originals and aired on Disney Channel from May 6th, 2005 til November 21st, 2008.

Synopsis
A teenage girl and her octopus best friend embark on adventures in the fictional city of Hitsonville, Michigan.

Main

 * /Shirley Mason/ (voiced by Lara Jill Miller) - a teenage girl who is cheerful and very helpful and generous.
 * /Octo/ (voiced by Billy West) - an octopus who has an ability to breathe in land, as well as Shirley's best friend.

Supporting

 * Jason Mason (voiced by Gregg Berger) - a dimwitted man who is Shirley's father. Despite his stupidity, he deeply cares for his kids, and tries to make sure they are safe.
 * Drake Mason (voiced by Tara Strong) - a mischevious little boy who likes messing with his sister and Octo.
 * /Taylor Ortiz/ (voiced by Debi Derryberry) - a tomboyish teenage girl who, despite not liking mostly girly stuff and mainly liking boy-ish stuff, actually likes wearing skirts (wearing a knee length jean skirt) and dresses as well as one of Shirley's close friends, she is confirmed to be a lesbian, and it is hinted that she has feelings for Shirley. Due to being insulted by tomboys due to her liking on skirts and dresses, she is pretty sensitive.
 * Mr. Dante Richards (voiced by TBD) - A serious yet somewhat nice teacher
 * Jayden MaCoy (voiced by Phil LaMarr) - a chill African-American teenager who is one of Shirley's best friends.
 * Marvin Atkins (also voiced by Billy West) - a comedic teenager who is also one of Shirley's best friends.
 * Cindy Brady (voiced by Catherine Taber) - an easily bored teenage girl who is one of Shirley's best friends.
 * Henry the Sloth (voiced by Brian Stepanek) - a cartoon sloth who hosts a very friendly educational show Fun Times with Henry!, being Drake's (and secretly Shirley's) favorite show.
 * Suzy Saunders (voiced by Grey DeLisle) - a cynical and quiet goth girl who usually tends to be snarky towards other teenagers, including Shirley, yet she does have sympathy.
 * Jonathan (voiced by TBD) - a friendly hammerhead shark who is well known friends with Octo.
 * William "Billy" Richardson (voiced by Carlos PenaVega) - a smart and intelligent teenage boy who is easily irritated by Shirley, but does find her as a good friend.
 * Anna and Anthony (voiced by TBD and TBD, respectively) - a kind goldfish and a goofy shark who are best friends, living together as roommates and helped Octo escape the aquarium to return to Shirley. It is implied they have a crush on each other.
 * Axy (voiced by Frank Welker) - an axolotl who is in the Hitsonville Aquarium, and one of the sea creatures that helped Octo escape the aquarium.
 * Lobso (voiced by Doug Lawrence) - a cowardly lobster who is in league with the Aquarium head.
 * Tangy (voiced by Jennifer Hale) - a flirtatious blue tang.
 * [clownfish]
 * John Phillips (voiced by TBD) - a jolly overweight man who is the owner of the all-you-can-eat restaurant Taylor got obsessed with, named Silver Buffet.
 * Fenella (voiced by Jessica DiCicco) - a Face Paint girl from the show Fenella, which is Shirley's favorite show.
 * Abigail Allison (voiced by TBD) - a teenage girl who is geeky and likes various TV shows and movies, like sci-fi movies, horror movies, etc.
 * The Wise Crab (voiced by Kenan Thompson) - an elderly yet wise crab who resides on a giant mountain and gives people wisdom.

Antagonists

 * Mary Barron (voiced by Kath Soucie) - a spoiled teenage girl who wants to be the most popular girl in school as she often pokes fun at Shirley and her friends, as well as leading a group of girls who are like Mary.
 * Masie Rangles (also voiced by Jennifer Hale) - one of Mary's best friends who is dumb.
 * TBD
 * The Dog (vocal effects by TBD) - a crazy dog who has gotten Octo.
 * Katherine Haines (voiced by Ashley Johnson) - a tomboyish, but rude girl who made fun of Shirley, due to her likings on skirts.
 * Carrie Jeckins (voiced by Hynden Walch) - a girl who pretends to be Shirley’s friend just so that she can steal one of her treasures.
 * Mr. Aqua (voiced by - the head of the Aquarium who wants to keep Octo in there.
 * The Lake Marine Monster (vocal effects by TBD) - a hostile angelerfish-like humanoid creature who is said to inhabit the depths of Lake Marine, as he is capable of taking down boats and eating whatever living thing it can find, as it can even walk on land near Lake Marine.
 * The Louse (non-speaking) - a rat-sized louse who got inside Octo's mouth and took control of him.
 * Harry Williams (voiced by TBD) - a crazy aquarium worker who trapped Octo in the tank when he was lost.
 * Squick (voiced by Jim Cummings) - a rude squid who has been Octo's rival since they were younger.
 * Bloodcurdler (voiced by Kirk Thornton) - an alligator who tried to eat Octo.
 * Ralph (voiced by TBD) - a talking bullfrog who is a massive bully towards anyone, especially Octo and swamp animals.

Episodes
See List of episodes.

Comic book adaption
See Octopus is My Best Friend Forever.

Transcripts
See /Transcripts.

Tropes
See /Tropes.