Yu-Gi-Oh! Generation Forever

Yu-Gi-Oh! Generation Forever is the final series of the Yu-Gi-Oh franchise. The series follows the protagonists, Yugi Muto, Jaden Yuki, Yusei Fudo, Yuma Tsukumo, Yuya Sakaki, and Yusaku Fujiki, as they enter Duel Academy, the number one school for duelists. However, as they go to class and learn the importance of life, they also found themselves facing evil of many kinds.

Plot
A mysterious scientist has fuse many timelines, causing them all to become one. Due to this, everyone is unaware that Time and Space has change. This includes of many people of not knowing that they're famous Pro Duelists in their adult years.

The protagonists have enter Duel Academy for their goals. With all six of them sharing a room together, the main characters soon learn that their days at Duel Academy will be more than just going to class and having duels.

Protagonists

 * Yugi Muto - The 16 year old protagonist of the first series Duel Monsters and the King of Games.
 * Jaden Yuki - The 15 year old protagonist of the second series GX. 
 * Yusei Fudo - The 18 year old protagonist of the third series 5D's. 
 * Yuma Tsukumo - The 13 year old protagonist of the fourth series Zexal. 
 * Yuya Sakaki - The 14 year old protagonist of the five series ARC-V. 
 * Yusaku Fujiki - The 16 year old protagonist of the sixth series Vrains.