Rise of the Powerpuff Girls/Home media

Marketing
The teaser trailer releases on April 7, 2018, posted on the Cartoon Network and Warner Bros. Pictures YouTube channels. A second teaser trailer will release on July 20, 2018. McDonalds is to release Happy Meal toys to promote the film. WaterTower Music and Cartoon Network Records released the film's soundtrack. On October 12, 2018, promotional tie-ins on Cartoon Network consist of bumpers with Blossom, Bubbles and Buttercup in a movie theater announcing the film. In addition, they host the entire line-up, in intermissions between commercial break.

Theatrical release
The movie will be released in the United States and United Kingdom on November 9, 2018. The film's theatrical release will be preceded by Wilderness Cove, a short film based on Cartoon Network's animated television series Craig of the Creek.

Home media release
The film was released on Digital on January 15 and Blu-Ray and DVD on February 5, 2019. It contains the deleted scenes, a Craig of the Creek short film Wilderness Cove, the 18-minute featurette, the behind-the-scenes look at Rise of the Powerpuff Girls, featuring interviews with most of the principal cast and crew, animatics, the first episode from Season 1, the audio commentaries and the sneak peek of The Fairly OddMovies.