The Simpsons II:Journey to the 5th Dimension

Characters
Lord Darkness(Herb)-Homer's long-lost half-brother.

Plot
They set course to Earth, but after a call from Abe, the family plans to go anywhere else but home. Bart and Lisa tries to escape and surely after, Bart and Lisa are infected. Then, the credits starts. Heroric music plays over a flying shot of a post-apocalyptic Springfield

Notes & Trivia

 * Due to the show being canceled the previous year,The Simpsons II is the finale to the show
 * The original name for the movie was going to be The Simpsons 2:INFECTION