The Mightypuff Girls

 is an American action-adventure-comedy superhero comic book series based on , being published by since TBD 2017.

Synopsis
Set in a distant future in the City of Qwertysville, three teenage girls join forces to face several threats that haunt their hometown.

Main

 * Mecha Utonium - the leader of the trio and Blossom's descendant who is extremely intelligent, providing the team with her own gadgets.
 * Mena Utonium - the ditziest of the trio and Bubbles' descendant who is obsessed with cute animals and fashion.
 * Meteor Utonium - the strongest of the trio and Buttercup's descendant who often gets into trouble due to her short temper and aggressivity.

Original

 * Hera - a mysterious goddess who grants the girls new powers known as TBD.

Descendants

 * Prof. Chase Utonium - a scientist who is the Mightypuff Girls' creator/father and Professor Utonium's descendant, being very caring and protective of them.
 * The Mayor of Qwertysville - the Mayor of Townsville's descendant who TBD.
 * Ms. Sasha Bellum - the Mayor's assistant and Ms. Bellum's descendant who TBD.
 * Ms. Kristen Keane - the Mightypuff Girls' teacher at Qwertysville High School and Ms. Keane's descendant who TBD. It's later revealed she's dating Utonium.
 * Carolyn Snyder - the Mightypuff Girls' best friend and Robin Snyder's descendant who sometimes helps them.

Original

 * Dolores Megabytes - Duchess Megabytes' mother who is the head of Megabytes Corporation, being out to TBD.

Descendants

 * Mojo Jupiter - a genetically modified chimpanzee and Mojo Jojo's descendant who wants revenge on Utonium for rejecting TBD.
 * It - a powerful demon and Him's descendant who aims to destroy TBD.
 * Duchess Megabytes - a rich spoiled brat and Princess Morbucks' descendant who desires to be a Mightypuff Girl, even if it implies murder.
 * Lord Silico - TBD
 * Fluffy Lumpkins - a hillbilly creature and Fuzzy Lumpkins' descendant who tries TBD.
 * The Cygreen Gang, consisting of:
 * Spade Copular - TBD
 * Jasmine "Serpent" Ingleberry - TBD
 * Armando "Lil' Armando" de la Guerra - TBD
 * [Grubber] - TBD
 * Daniel "Big Danny" Williams - TBD
 * Sedustara - a seductive medusa-like figure and Sedusa's descendant who TBD.
 * The Amoeba Gang, consisting of:
 * Extreme Leader - TBD
 * Youngster - TBD
 * Slender - TBD

Trivia

 * This comic has a similar premise to Loonatics Unleashed.
 * While most of the concepts are based in the 1998 series, some elements from the 2016 series are incorporated into it as well.