Osmosis Jones 2: Body Works

Osmosis Jones 2: Body Works is a 2029 American live-action/animated action-adventure comedy film with animated scenes directed by Tom Sito and Gary Trousdale and live-action scenes directed by the Farrelly brothers. Produced by Warner Animation Group, it is a sequel to Osmosis Jones (2001) and stars Chris Rock, David Hyde Pierce, Brandy Norwood, Laurence Fishburne, Anthony Mackie, Charlie Sheen, Chloe Grace Moretz, Jimmy Kimmel, Ron Howard, Molly Shannon, Chris Elliott, and Bill Murray. The film is set 7 years after the events of the first film, in which Ozzy and Drix are called into to save the City of Frank, for Thrax has been revived by a scientist and threatens to wreak havoc on the City of Frank. The film was released on August 10, 2029, by Warner Bros. Pictures. It received mixed reviews from critics and grossed over $348 million worldwide.

Synopsis
Set 7 years after the events of the first film, Ozzy and Drix, now partners, are called into action when an unknown contagious virus invades the City of Frank, with intentions on killing Frank's entire immune system.

Cast
Animation voice cast Live-action cast
 * Chris Rock as Osmosis "Ozzy" Jones, a blue and white blood cell who works for the City of Frank Police Department.
 * David Hyde Pierce as Drixenol "Drix" Koldreliff, a red and yellow cold pill who is Ozzy's partner and best friend.
 * Brandy Norwood as Leah Estrogen, a former secretary for Mayor Phlemming and Ozzy's girlfriend. She became Thrax's minion by his evilized bracelets.
 * Laurence Fishburne as Thrax that invades the City of Frank, revived by a scientist.
 * Anthony Mackie as the scientist who revives Thrax.
 * Charlie Sheen as Dale Williams, a rookie for the City of Frank Police Department.
 * Ron Howard as Tom Colonic, the current mayor of the City of Frank.
 * Joel Silver as the police chief, Ozzy and Drix's boss.
 * William Shatner as Phlegmming, the ex-mayor of the City of Frank.
 * Bill Murray as Frank Detorre, a zookeeper at Detorre's Zoo, Bob's brother, and Shane's father.
 * Chloe Grace Moretz as Shane Detorre, Frank's 17-year old daughter. She was previously portrayed by Elena Franklin in the first film.
 * Molly Shannon as Mrs. Detorre, Shane's mom who somehow disappeared in the Lost Souls Canyon.
 * Chris Elliott as Bob Detorre, Frank's brother, Shane's uncle, and the owner of Detorre's Zoo.