The Powerpuff Girls: Unleashed

 is an American animated action-adventure-comedy television series, serving a reboot to and, being created by Craig McCracken. It is produced by Cartoon Network Studios and will premiere on Cartoon Network, with reruns on WB Kids and Boomerang, on TBD. The series is rated TV-Y7-FV.

Main

 * Blossom Utonium (voiced by Cathy Cavadini) - TBD
 * Bubbles Utonium (voiced by Tara Strong) - TBD
 * Buttercup Utonium (voiced by E.G. Daily) - TBD

Supporting

 * Professor Utonium (voiced by Tom Kane) - TBD
 * The Narrator (voiced by Tom Kenny) - TBD
 * The Mayor of Townsville (also voiced by Tom Kenny) - TBD
 * Ms. Sara Bellum (voiced by Jennifer Martin) - TBD
 * Ms. Keane (voiced by Jennifer Hale) - TBD

Antagonists

 * Mojo Jojo (voiced by Roger L. Jackson) - TBD
 * Him (also voiced by Tom Kane) - TBD
 * Princess Morbucks (also voiced by Jennifer Hale) - TBD
 * Silico (voiced by Diedrich Bader) - TBD
 * Fuzzy Lumpinks (voiced by Jim Cummings) - TBD
 * Manboy (voiced by John DiMaggio) - TBD
 * The Gangreen Gang, consisting of:
 * Ace Copular (voiced by Jeff Bennett) - TBD
 * Sanford "Snake" Ingleberry (also voiced by Tom Kenny) - TBD
 * Arturo "Lil' Arturo" de la Guerra (also voiced by Tom Kenny) - TBD
 * Grubber (also voiced by Jeff Bennett) - TBD
 * William "Big Billy" Williams (also voiced by Jeff Bennett) - TBD
 * Sedusa (also voiced by Jennifer Hale) - TBD
 * White Kitty (voiced by Mark Hamill) - TBD
 * The Amoeba Boys, consisting of:
 * Bossman (voiced by Ray Romano) - TBD
 * Junior (voiced by Nolan North) - TBD
 * Slim (voiced by Travis Willingham) - TBD

Trivia

 * Despite being a reboot to the 1997 series, 2016 characters also appear.